Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines by G. Martinasso, M. Oraldi, A. Trombetta, M. Maggiora, O. Bertetto, R. A. Canuto, G. Muzio

“…PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. “In vivo” PPARγ and α were evaluated in colon cancer specimens and adjacent nonneoplastic colonic mucosa. …”
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Ribosomes: An Exciting Avenue in Stem Cell Research by Zhenzhen Han, Qi Zhang, Yanbo Zhu, Jingcheng Chen, Wei Li

“…Ribosomes induce cellular transdifferentiation and reprogramming, and disrupted ribosome synthesis affects translation efficiency, thereby hindering stem cell function leading to cell death and differentiation. Stem cell function is regulated by ribosome-mediated control of stem cell-specific gene expression. …”
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Staging model for amyotrophic lateral sclerosis in Singapore by Yuan Teck Tay, Josiah YH Chai, Kamilah Bte Shekh Jabin, Kexin Ang

“…Standardised timings from disease onset (0) to death (1) among Singapore patients with ALS were measured. …”
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Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair by Jiahao Ren, Xinzhe Chen, Tao Wang, Cuiyun Liu, Kun Wang

“…Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes. …”
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Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally by Sevinch Mahmudova, Gulnar Elizade, Nezrin Hesenli, Turab Janbakhishov, Sarkhan Elbayiyev

“…Severe HDFN can cause hydrops fetalis and fetal death if left untreated, whereas survivors often face complications like neonatal anemia and hyperbilirubinemia, potentially causing kernicterus. …”
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Simulating human behavior under earthquake early warning by Matthew Wood, Sara K. McBride, Xilei Zhao, Dare Baldwin, Elizabeth S. Cochran, Xiaojian Zhang, Nicolas Luco, Ruggiero Lovreglio, Tom Cova

“…Earthquakes are a rapid-onset hazard where advance planning and learning plays a key role in mitigating injuries and death to individuals. Recent advances in earthquake detection have resulted in the development of earthquake early warning (EEW) systems. …”
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Biomarkers in metastatic castration-resistant prostate cancer for efficiency of immune checkpoint inhibitors by Zixi Wu, Junbiao Zhang, Le Li, Zhihua Wang, Chunguang Yang

“…However, while immune checkpoint inhibitor monotherapy or combination therapy targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and/or programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) axis has been regarded as the standard therapy in many solid tumours, mCRPC as ‘cold’ tumours are considered to be relatively resistant to ICB treatment. …”
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Feedback regulation in multistage cell lineages by Wing-Cheong Lo, Ching-Shan Chou, Kimberly K. Gokoffski, Frederic Y.-M. Wan, Arthur D. Lander, Anne L. Calof, Qing Nie

“…Here we report on the existence and uniquenessof steady states in this system, as well as local and global stability of these steady states.In particular, we identify parameter conditions for the stability of the system when negativefeedback loops are represented either as Hill functions, or in more general terms.Our results suggest that two factors -- autoregulation of the proliferation oftransit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system.…”
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Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia by Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang

“…Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. …”
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Analyzing COVID-19 progression with Markov multistage models: insights from a Korean cohort by Frank Aimee Rodrigue Ndagijimana, Taesung Park

“…Although transition rates to death were low early in hospitalization, these comorbidities significantly increased the likelihood of worsening conditions. …”
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Governance and Poverty Eradication Policy Performance During the NRM Administration in Uganda 1986 – 2020. by Mucunguzi, Abel, Katabaazi, Anny Bwengye

“…Poverty in Uganda is attributed to diseases, limited access to land, large families, lack of markets for agricultural produce, lack of credit facilities, lack of education and vocational training, lack of jobs, high unfair taxes and market dues, death of family bread winners, ignorance and lack of information, idleness and laziness, insurgency and gender inequalities among others. …”
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Improved estimates for extinction probabilities and times to extinction for populations of tsetse (Glossina spp) by Damian, Kajunguri, Elisha B., Are, John W., Hargrove

“…Because females only produce a single offspring approximately every 10 days, imposing a death rate of greater than about 3.5% per day will ensure the eradication of any tsetse population. …”
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Assessing the Factors Influencing Youth Violence in Local Community: A Case Study of Kashambya Sub-County Rukiga District. by Asiimirwa, Crissy

“…From the findings, it was established that there is a big negative impact of youth violence to the community such as death to community members as well as a reduction in the economic development of the county.…”
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Prospective cohort study comparing outcomes between vacuum extraction and second-stage cesarean delivery at a Ugandan tertiary referral hospital by Barbara, Nolens, Flavia, Namiiro, John, Lule, Thomas, van den Akker, Roosmalen, Jos van, Josaphat, Byamugisha

“…Results: Among 13 152 deliveries, 358 women who underwent vacuum extraction and 425 women who underwent SSCD were enrolled in the study. No maternal deaths occurred after vacuum extraction versus five deaths from complications of SSCD. …”
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Governance and poverty eradication policy performance during the NRM1 Administration in Uganda 1986 – 2020 by Mucunguzi, Abel, Bwengye, Katabaazi Anny

“…Poverty in Uganda is attributed to diseases, limited access to land, large families, lack of markets for agricultural produce, lack of credit facilities, lack of education and vocational training, lack of jobs, high unfair taxes and market dues, death of family bread winners, ignorance and lack of information, idleness and laziness, insurgency and gender inequalities among others. …”
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Allium Cepa (Onion) Extract Enhances and Protects Testicular Function and Architecture against Paraquat Induced Oxidative Damage. by Uzozie Chikere, Ofoego, Ejike, Daniel Eze

“…Paraquat administration caused significantly (P<0.05) reduced sperm count, motility, alteration in sperm morphology and induced cell death. Oral gavage of paraquat also caused significant (P<0.05) decrease in serum testosterone and SOD levels with concomitantly elevated MDA levels. …”
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Optimal control analysis of Taenia saginata bovine cysticercosis and human taeniasis by Damian, Kajunguri, Joshua, A. Mwasunda, Jacob I, Irunde

“…Sensitivity analysis results indicate that human’s and cattle’s recruitment rates, infection rate of cattle from contaminated environment, probability of humans to acquire taeniasis due to consumption of infected meat, defecation rate of humans with taeniasis and the consumption rate of raw or undercooked infected meat are the most positive sensitive parameters whereas the natural death rates for humans, cattle, Taenia saginata eggs and the proportion of unconsumed infected meat are the most negative sensitive parameters in diseases’ transmission. …”
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Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

“…Background Targeting the PD-1/PD-L1/L2 (programmed cell death protein 1/programmed cell death ligand 1/ligand 2) pathway combined with other immunosuppressive signalings, such as CD73/A2aR (A2a adenosine receptor) adenosine signaling, has emerged as a promising strategy for cancer treatment. …”
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Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Li... by Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao

“…Enrolled adult patients with ALF undergoing PE were divided into a survival group and a death group at discharge and 90 days on account of medical records and telephone follow-up. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…R. solani induces cell death in plants by secreting enzymes and toxins. …”
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