Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets by Giovanna Morello, Antonio Gianmaria Spampinato, Sebastiano Cavallaro

“…Despite the mechanism underlying motor neuron death is not yet clarified, multiple pathogenic processes have been proposed to account for ALS. …”
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A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age by Eric Roehm

“…For every 37 women randomized to CEE at 50–59 years, one less woman experienced a global index endpoint (including coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, hip fracture, and death) during the 13-year follow-up. Younger women (50–59 years), compared to older women, had more favorable cumulative long-term outcomes for MI and global index. …”
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Perbedaan Tingkat Kecukupan Vitamin A, Zat Besi, dan Zink pada Balita Stunting dan Non Stunting di Kabupaten Banyuasin by Titin Dewi Sartika Silaban, Sendy Pratiwi Rahmadhani, Turiyani Sugiman

“…Toddlers who lack vitamin A, iron, and zinc can cause cognitive and physical impairment and an increased risk of death. Objectives: To determined the difference in the level of adequacy of vitamin A, the level of adequacy of iron and the level of adequacy of zinc in stunting and non-stunted toddlers. …”
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Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease by Ahmet Dursun, Hatice Gul Durakbasi-Dursun, Ayse Gul Zamani, Zerrin Gülin Gulbahar, Recep Dursun, Cengiz Yakicier

“…The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. …”
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Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application by Kaichun Li, Jin Li

“…Despite the great progress in the treatment of gastric cancer, it is still the third leading cause of cancer death worldwide. Patients often miss the opportunity for a surgical cure, because the cancer has already developed into advanced cancer when identified. …”
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A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies by Ammar ELJack, Mohamad El Abdallah, Kadhim Al-Banaa, Kashif Chaudhry, Faisal Musa

“…It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higher rate of complications and mortality. …”
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Gastrointestinal Stromal Tumours: Etiology, Pathology and Clinical Management by Martin E Blackstein, Pierre Dubé, Jonathan A Fletcher, Oliver R Keller, Margaret Knowling, Richard Létourneau, Donald Morris, Robert Riddell, Stewart Rorke, Carol J Swallow, Canadian Advisory Committee on GIST

“…Investigation of the regulation of cell growth, differentiation and death by signalling pathways has led to a greater understanding of how alterations in these pathways play a critical role in the development of some cancers, and has opened new opportunities for their treatment. …”
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A clinical dilemma, the diagnosis of ectopic pregnancy by Carlos Moya Toneut, Javier Cruz Rodríguez, Miguel Román Sarduy Nápoles

“…It is one of the first causes of death in the first quarter of pregnancy. Objective: assess ectopic pregnancy as a clinical dilemma for diagnosis. …”
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Dignity and Deferral Narratives as Strategies in Facilitated Technology-Based Support Groups for People with Advanced Cancer by Annette F. Street, Kate Wakelin, Amanda Hordern, Nicola Bruce, Dell Horey

“…Two dominant participant narratives emerged: a focus on dying with dignity or an interest in deferring discussion of death and dying to focus on the present. Despite the different approaches, participants found the technology-based support groups to be accessible and safe environments in which to discuss difficult topics in privacy. …”
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Meningococcal B Vaccination (4CMenB) in Infants and Toddlers by Susanna Esposito, Claudia Tagliabue, Samantha Bosis

“…One of the leading causes of death in the world, N. meningitidis can be responsible for nearly 1,000 new infections per 100,000 subjects during an epidemic period. …”
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Exploring the perspectives of child health strategy stakeholders on resilience and well-being in children and youths in Singapore: A qualitative study by Yee Keow Chiong, Kee Seng Chia

“…The factors associated with resilience are homogeneous across studies, which are individual attributes such as self-regulation and problem-solving skills, relational attributes such as secure attachment relationships, and connections to school and community.4 This is relevant to the Singaporean context, as the Singapore Mental Health Study conducted from 2016 to 2018 revealed that 1 in 5 youths, aged between 18 and 34 years old have a mental disorder.5 Mental disorders were also reported to be the largest contributor to disease burden for Singaporeans aged 10 to 34 years old, peaking for 15 to 19 year-olds, for whom it represented 25.8% of total disability-adjusted life years (DALYs).5 In 2020, suicide is the leading cause of death for those aged 10 to 29 years old. Parent-child relationships are the focus of resilience studies in how they shape a child’s resilience to bounce back after encountering adversities. …”
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Multidrug-Resistant Pathogens in Burn Wound, Prevention, Diagnosis, and Therapeutic Approaches (Conventional Antimicrobials and Nanoparticles) by Jaber Hemmati, Mehdi Azizi, Babak Asghari, Mohammad Reza Arabestani

“…Multidrug-resistant pathogens are one of the common causes of death in burn patients and have a high risk of nosocomial infections, especially pneumonia, urinary tract infections, and cellulitis. …”
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Acute Toxicity and Antioxidant and Antibacterial Activities of Kyllinga polyphylla Willd. ex Kunth, Cyperaceae Family by Van-Ay Nguyen, Thi-Hang Phung, Thi-Diem-Trang Kieu, Trong-Hong-Phuc Nguyen

“…KP extracts did not cause death at a dose of 5000 mg/kg body weight and did not significantly change the biochemical, hematological, as well as histological structures of internal organs in toxicity-tested mice in comparison with the control. …”
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The instrumental value of advance directives: lesson learned from the COVID-19 pandemic for policymaking by Elisabeth Stock, Christian H. Nickel, Bernice S. Elger, Andrea Martani

“…We show, with particular reference to lessons learned from the COVID-19 pandemic, that AD are instrumentally valuable in that they: (1) allow to thematise death; (2) ensure that overtreatment is avoided; (3) enable to better respect the wish of people to die at their preferred place; (4) help revive the “lost skill” of prognostication. …”
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Optimizing Bone Health in Duchenne Muscular Dystrophy by Jason L. Buckner, Sasigarn A. Bowden, John D. Mahan

“…Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle weakness, with eventual loss of ambulation and premature death. The approved therapy with corticosteroids improves muscle strength, prolongs ambulation, and maintains pulmonary function. …”
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An Unusual Case of Fulminant Type 1 Diabetes during the Second Trimester of Pregnancy by Tomohiro Okuda, Sadao Yamashita, Yoshio Ogino, Hisashi Kataoka, Jo Kitawaki

“…Although this disease is rare, its progression is rapid, and its clinical course is severe and occasionally leads to death; therefore, a full knowledge of the disease is important to facilitate an accurate diagnosis.…”
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Arrhythmia Classification Techniques Using Deep Neural Network by Ali Haider Khan, Muzammil Hussain, Muhammad Kamran Malik

“…Cardiac arrhythmia can be dangerous, or in most cases, it can cause death. The arrhythmia can be of different types, and it can be detected by an ECG test. …”
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Subacute Right Ventricle Perforation by Pacemaker Lead Presenting with Left Hemothorax and Shock by Julianne Nichols, Natalie Berger, Praveen Joseph, Debapriya Datta

“…Acute perforations occurring within twenty-four hours of insertion of pacemaker can lead to hemopericardium, cardiac tamponade, and death. Hemothorax occurring as an acute complication of pacemaker insertion is reported but extremely rare. …”
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Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues by Bahadır Öztürk, Zahide Esra Durak, Süleyman Büber, Ender Hilmi Kocaoğlu

“…This event caused by SMF might play part in the death of cancer cells, which may be a good supportive vehicle for the cancer therapy.…”
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Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model by Yuanyuan Zhang, Kewei Tian, Hong Jiang, Beibei Wang, Shu Han

“…Our results demonstrated that this combination therapy significantly decreased disease severity, inflammatory cell infiltration, secondary demyelination, and axonal loss, thus reducing neural death. In conclusion, our study suggests a possible treatment that can relieve progressive blindness and paralysis in an animal model of NMO through improvement of the inflammatory milieu.…”
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