The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology by Steven Eric Finkelstein, Robert Timmerman, William H. McBride, Dörthe Schaue, Sarah E. Hoffe, Constantine A. Mantz, George D. Wilson

“…Herein, we will discuss how SABR can induce cellular expression of MHC I, adhesion molecules, costimulatory molecules, heat shock proteins, inflammatory mediators, immunomodulatory cytokines, and death receptors to enhance antitumor immune responses.…”
Get full text

Imaging the Abdominal Manifestations of Cystic Fibrosis by C. D. Gillespie, M. K. O’Reilly, G. N. Allen, S. McDermott, V. O. Chan, C. A. Ridge

“…Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. …”
Get full text

Combination Therapy of PPAR𝛾 Ligands and Inhibitors of Arachidonic Acid in Lung Cancer by Jordi Tauler, James L. Mulshine

“…Lung cancer is the leading cause of cancer death in the United States and five-year survival remains low. …”
Get full text

PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Lung cancer is the leading cause of cancer-related death, with more than half the patients having advanced-stage disease at the time of initial diagnosis and thus facing a poor prognosis. …”
Get full text

CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study by Saba Mirzaei, Mahdieh Salimi, Hossein Mozdarani

“… Background: Breast cancer is the leading cause of death for women worldwide. Optimal methods for most cancer control require the use of appropriate biomarkers. …”
Get full text

Ultrastructural and Molecular Changes in the Developing Small Intestine of the Toad Bufo regularis by S. A. Sakr, G. M. Badawy, H. T. El-Borm

“…In conclusion, the recorded remodeling of the small intestine represents a model for clarifying the mechanism whereby cell death and proliferation are controlled.…”
Get full text

Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production and cell cycle arrest by Shao Linhai, Shao Yajun, Yuan Yu

“…Pinocembrin induced regulatory effects over expressions of caspase-3, caspase-9, Bax and Bcl-2, thereby promoting apoptotic cell death in PC-3 cells. It also led to the dose-dependent G0/G1 cell cycle arrest. …”
Get full text

Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature by Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M. Crumley, Ashley Drews

“…Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. …”
Get full text

Cord Blood-Derived Hematopoietic Stem/Progenitor Cells: Current Challenges in Engraftment, Infection, and Ex Vivo Expansion by Katsuhiro Kita, Jong O. Lee, Celeste C. Finnerty, David N. Herndon

“…Infections and relapse are the major causes of death after cord blood transplantation in patients with hematopoietic diseases. …”
Get full text

Asthma in Sickle Cell Disease: Implications for Treatment by Kathryn Blake, John Lima

“…Having asthma increases the risk for developing acute chest syndrome , death, or painful episodes compared to having sickle cell disease without asthma. …”
Get full text

Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis by Yinzi Xin, Wei Wang, Enyu Mao, Hefeng Yang, Song Li

“…It was involved in the progress of a programmed cell death called pyroptosis, which was caspase-1 dependent and ultimately triggered inflammatory mediator interleukin IL-1β release. …”
Get full text

Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications by Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee

“…Diabetes, a metabolic disorder characterized by elevated fasting blood glucose levels, affects nearly 8% of the world population and was predicted that it would be the top seven leading cause of death in the next ten years. The incidence of diabetes and its morbidity are increasing rapidly in developing countries due to lifestyle change and intake of high-calorie diet occurring with urbanization. …”
Get full text

PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation. by Lujie Zhang, Yanni Gao, Haoran Zhou, Xiao Liang, Xiaolin Jiang, Wenqin Gong, Yangyang Sun, Desheng Zhang, Xianwei Wang, Hans Nauwynck, Juan Bai, Ping Jiang

“…Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2), belonging to the family Arteriviridae, triggers dysregulated cytokine release and interstitial pneumonia, which can quickly escalate to acute respiratory distress and death. However, a mechanistic understanding of PRRSV-2 progression remains unclear. …”
Get full text

Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages by E. E. Mannick, J. Mishra, J. Marque, M. Clavell, M. J. S. Miller, P. D. Oliver

“…The precise role of the transcription factor nuclear factor kappa B (NF- κB) in the regulation of cell survival and cell death is still unresolved and may depend on cell type and position in the cell cycle. …”
Get full text

Extreme Gradient Boosting Model with SMOTE for Heart Disease Classification by Ahmad Ubai Dullah, Aditya Yoga Darmawan, Dwika Ananda Agustina Pertiwi, Jumanto Unjung

“… Heart disease is one of the leading causes of death worldwide. According to data from the World Health Organisation (WHO), the number of victims who die from heart disease reaches 17.5 million people every year. …”
Get full text

The Role of Glucose, Serum, and Three-Dimensional Cell Culture on the Metabolism of Bone Marrow-Derived Mesenchymal Stem Cells by Byron Deorosan, Eric A. Nauman

“…However, cells cultured in low density collagen exhibited considerable cell death, likely because of physical contraction of the collagen hydrogel which was not observed in the higher density collagen. …”
Get full text

Study of information needs of students in the field of environmental policy by I. D. Porfirieva

“…The data obtained allowed to substantiate the conclusions about the need for fundamental changes in educational programs, toughening legal regulations in the field of environmental management as a mechanism to counter the extinction and death of civilization.…”
Get full text

Volatile Organic Metabolites as Potential Biomarkers for Genitourinary Cancers: Review of the Applications and Detection Methods by Kiana L. Holbrook, Wen-Yee Lee

“…Cancer is one of the leading causes of death globally, and is ranked second in the United States. …”
Get full text

Aerococcus viridans Native Valve Endocarditis by Wenwan Zhou, Vanessa Nanci, Andreanne Jean, Amir H Salehi, Fahad Altuwaijri, Renzo Cecere, Jacques Genest

“…A viridans endocarditis appears to be particularly virulent, requiring a surgical approach in four of 10 cases reported and death in one of nine. Given the aggressive nature of A viridans endocarditis and the variable time to diagnosis (a few days to seven months), prompt recognition of symptoms and echocardiography, in addition to blood cultures, should be performed when symptoms persist.…”
Get full text

Meaning and Practice of Palliative Care for Hospitalized Older Adults with Life Limiting Illnesses by Bethel Ann Powers, Sally A. Norton, Madeline H. Schmitt, Timothy E. Quill, Maureen Metzger

“…Consistent with reports by other researchers, study data support the need to move beyond equating PC with hospice or EOL care and the notion that EOL is a well-demarcated period of time before death. If professional health care providers assume that PC services are limited to assisting with and helping patients and families prepare for dying, they miss opportunities to provide care considered important to older individuals confronting life-limiting illnesses.…”
Get full text