Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans by J. Payne, J. Payne, J. D. Sutton, B. E. Blackburn, S. Bansod, S. Bansod, H. Imlay, H. Imlay, E. S. Spivak, E. S. Spivak, J. Pupaibool, J. Pupaibool, J. M. Gililland, J. M. Gililland, L. K. Certain, L. K. Certain, L. K. Certain

“…Secondary outcomes included recurrent PJI and death.</p> <p><strong>Results</strong>: Of the 605 patients who underwent Stage 2 reimplantation for PJI, 154 patients received at least 14 d of antibiotics after surgery and 451 patients did not. …”
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Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…., adjudicated cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke), DVT, and PE was assessed in adults who received ≥ 1 dose of IXE across 25 randomized clinical trials (17 PsO, 4 PsA, 4 axSpA). …”
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Factors influencing in-hospital mortality for salvage percutaneous transjugular intrahepatic portosystemic shunting in cirrhotic patients with recalcitrant variceal bleeding after... by J E J Krige, E G Jonas, M Setshedi, S J Beningfield, U K Lotze, M M Bernon, S Burmeister, J C Kloppers

“…Factors associated with and predictors of death were determined using bivariate analysis and univariate logistic regression analysis. …”
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Short-term survivors with brain metastases have modest benefits from focal and systemic therapies and remain frequent despite improving treatment landscape by M. Czogalla, J. Stöhr, N. Gleim, K. Papsdorf, S. Klagges, P. Hambsch, T. Kuhnt, F. Nägler, A. Barrantes-Freer, J. Wach, N.H. Nicolay, C. Seidel

“…Clinical and treatment characteristics, pathological data and causes of death were documented. Descriptive statistics, treatment-specific univariate Kaplan-Meier estimator analyses and multivariate Cox regression were performed. …”
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Intra-mesenteric steroids for steroid-refractory graft-versus-host disease in pediatric patients: A safe option by Ana M. Aristizábal, Lina P. Montaña, Jaiber Gutiérrez, Diego Medina, Alexis A. Franco, Eliana Manzi, Ángela Devia Zapata, Walter Mosquera

“…Twelve patients (57%) died with one death due to acute graft-versus-host disease. Conclusion. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…Abstract Background Despite the recognized therapeutic potential of programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) inhibitors in advanced esophageal squamous cell carcinoma (ESCC), their role in neoadjuvant therapy and reliable efficacy biomarkers remain elusive. …”
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Long-Term Clinical Outcomes for Non-ST Elevation Acute Coronary Syndrome Patients with High-Risk Angiographic Findings Undergoing Percutaneous Coronary Intervention by Sida Jia, Ce Zhang, Yue Liu, Deshan Yuan, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao, Jinqing Yuan

“…Patients in the HRCA group had higher incidence of unplanned revascularization (2 years: 9.7% vs. 5.1%, p<0.001; 5 years: 15.4% vs. 10.3%, p<0.001), 2-year MACCE (13.1% vs. 8.8%, p<0.001), and 5-year death/MI/revascularization/stroke (23.0% vs. 18.4%, p=0.001). …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…BV-2 microglial cells undergo necrotic cell death resulting in DAMP release due to OGD/R-induced injury. …”
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Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Histological examination confirmed the loosening integrity of tumoroids in MTF-treated groups, especially 120 mM MTF, with the increase in cell death via the induction of apoptosis (chromatin marginalization) and necrotic (pyknotic nuclei) changes. …”
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Increased serum soluble PD-l1 levels in patients with advanced stages of chronic kidney disease by Ayaka Hayashi, Ayaka Hayashi, Hiroto Ishihara, Mayuko Kawabe, Kazuhiko Kato, Kazuhiko Kato, Akio Nakashima, Akio Nakashima, Izumi Yamamoto, Teppei Sakano, Teppei Sakano, Hiroe Kobashi, Makoto Morita, Makoto Morita, Takashi Yokoo, Mitsuyoshi Urashima

“…BackgroundProgramed death-ligand 1 (PD-L1) is overexpressed on renal tubular and vascular epithelial cells in inflammatory kidney diseases as well as on aged kidney podocytes, contributing to chronic kidney disease (CKD) progression. …”
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Optimasi Algoritma Naive Bayes dengan Diskritisasi K-Means pada Diagnosis Penyakit Jantung by Nafa Fajriati, Budi Prasetiyo

“…Diagnosing heart disease early can help reduce the risk of death and the high costs of treatment for heart disease. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Oxidative damage-triggered immunogenic cell death (ICD) in turn leads to the polarization of macrophages to the M1 phenotype, inducing immunogenic cell death and inhibiting tumor cell proliferation and metastasis.Discussion: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. …”
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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…Abstract Background Our study investigated the role of experimental periodontitis on tumor growth, local and systemic immunosuppressive status, and programmed death receptor 1 (PD-1) / programmed death ligand 1 (PD-L1) expression in oral squamous cell carcinoma (OSCC) and prostate cancer. …”
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Hubungan Jenis Organ dan Jumlah Organ yang Mengalami Gangguan dengan Prognosis dan Outcome pada Pasien Malaria Falciparum Berat di RSUP Dr. M. Djamil Padang by Riche Anggresti, Nuzulia Irawati, Roza Kurniati Kurniati

“…</p><p>Abstract<br />Malaria is tropic infection disease able to cause death. Mortality increases in severe malaria because progress of disease very quickly cause death in 18-72 hour. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…The primary outcome was the occurrence of MACE (cardiovascular death, nonfatal myocardial infarction, and ischemic stroke). …”
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Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

“…At 90 days, 103 patients (44%, 95%CI 37–50) had unfavorable outcome, including 71 (30%) deaths. The most frequent intracranial complications were ischemic lesion (69/237 patients, 29%), diffuse cerebral oedema (43/237, 18%) and ventriculitis (36/237, 15%). …”
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Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

“…Conclusions: In contrast to CRP and GDF-15, increasing concentrations of hs-cTn, hs-cTnI, and NT-proBNP are associated with higher risk of death and CV events in female than in male patients presenting with suspected NSTE-ACS. …”
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A simple staging system using biomarkers for wild‐type transthyretin amyloid cardiomyopathy in Japan by Naoya Nakashima, Seiji Takashio, Mami Morioka, Masato Nishi, Toshihiro Yamada, Kyoko Hirakawa, Masanobu Ishii, Noriaki Tabata, Kenshi Yamanaga, Koichiro Fujisue, Daisuke Sueta, Hisanori Kanazawa, Tadashi Hoshiyama, Shinsuke Hanatani, Satoshi Araki, Hiroki Usuku, Eiichiro Yamamoto, Mitsuharu Ueda, Kenichi Matsushita, Kenichi Tsujita

“…Kaplan–Meier analyses revealed significant differences in all‐cause death and rehospitalization for heart failure (log rank test; P < 0.001), and after adjusting for sex and age, the hazard ratio of all‐cause death was 6.96 (95% Cl 2.88–16.83, P < 0.001) and that for rehospitalization for heart failure was 4.27 (95% Cl 2.26–8.07, P < 0.001) in the high‐risk group, compared with those in the low‐risk group. …”
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Southern Pine Beetle, Dendroctonus frontalis Zimmermann (Insecta: Coleoptera: Scolytidae) by James R. Meeker, Wayne N. Dixon, John L. Foltz, Thomas R. Fasulo

“…The galleries created by both the adult beetles and their offspring can effectively girdle a tree, causing its death. SPB also carry, and introduce into trees, blue-stain fungi. …”
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Application the Risk-Based Maintenance for Optimizing the Overall Medical Devices Safety by Khelood A. Mkalaf, Peter Gibson

“…Which, can affect the reputation of hospitals following the exposure of patients' lives to various risks like death, injury, and misdiagnosis. Furthermore, a sudden failure will lead to increased economic losses as a result of increased maintenance costs.  …”
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