mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae by Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao

“…Despite the widespread anti-microbial resistance and the high mortality rate, currently, no clinically vaccine is approved for battling K. pneumoniae. To date, messenger RNA (mRNA) vaccine is one of the most advancing technologies and are extensively investigated for viral infection, while infrequently applied for prevention of bacterial infections. …”
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STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren’s Syndrome: Association with Disease Susceptibility and Clinical Aspects by Serena Colafrancesco, Cinzia Ciccacci, Roberta Priori, Andrea Latini, Giovanna Picarelli, Francesca Arienzo, Giuseppe Novelli, Guido Valesini, Carlo Perricone, Paola Borgiani

“…A predisposing genetic background is likely, and, to date, several polymorphisms in non-HLA genes have been explored with interesting results. …”
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Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…Although Euphorbia genus is reported to have anticancer properties, E. thymifolia is not reported to have anticancer properties to date. Therefore, the aim of the present study was to screen the phytoconstituents and identify the active compounds present in the methanolic extract of E. thymifolia (ME.ET) as ligands to inhibit human cancer cell lines with special reference to potential protein targets implicated in breast cancer using an In-silico approach. …”
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Exploring expressed concerns and uncanny feeling in patients with shortness of breath calling out-of-hours primary care by Michelle Spek, Dorien L. Zwart, Esther de Groot, Michelle R. Timmerman, Maarten van Smeden, Daphne C. A. Erkelens, Anna S. M. Dobbe, Mathé Delissen, Frans H. Rutten, Roderick P. Venekamp

“…Trial registration The Netherlands Trial Register, number: NL9682, registration date: 20–08-2021.…”
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SSR marker-based genetic diversity and structure analyses of Camellia nitidissima var. phaeopubisperma from different populations by Yang-Jiao Xie, Meng-Xue Su, Hui Gao, Guo-Yue Yan, Shuang-Shuang Li, Jin-Mei Chen, Yan-Yuan Bai, Jia-Gang Deng

“…Background Camellia nitidissima var. phaeopubisperma is a variety in the section Chrysantha of the genus Camellia of the family Theaceae which is native to Fangchenggang, Guangxi, China. To date, the genetic diversity and structure of this variety remains to be understood. …”
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Changes in photoperiod during the dry period impact colostrum production in Holstein and Jersey cows by K.J. Alward, A.J. Duncan, A.D. Ealy, G.E. Dahl, C.S. Petersson-Wolfe, R.R. Cockrum

“…Holstein and Jersey cows (n = 33) were dried off 60 d before their due date and randomly assigned to SDPP (Holstein, n = 9; Jersey, n = 8) or LDPP (Holstein, n = 8; Jersey, n = 8) until calving. …”
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L’alimentation hydraulique de Saint-Romain-en-Gal (Rhône), quartier de Vienne antique (Isère) by Laurence Brissaud, Jean-Luc Prisset

“…Only the construction of the one with the largest section, the E, has been dated to the 20-30s AD. For its part, the development of aqueduct B was subsequent to the construction of conduits C and D because it reused sections of them on its route.On the right bank of the Rhône, a relatively large plain occupies the inside curve of the river, limited to the west by a continuous slope, likely punctuated by streams with moderate flows. …”
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SECOND WAVE AND PANDEMIC SITUATION OF COVID-(2020-2021) IN BANGLADESH by Ahasan Ullah Khan, Rumana Akter, Foyj Ullah Khan, Shakhera Khanom, Anayat Ullah Khan, Ayesha Shiddika Afsana

“…The positive correlation found between infested with tests and recovered with tests of April, 2021 by people where (R2= 0.5289, p<0.012 and 0.0000006 p<0.05) and the negative correlation found between tests with date and death with tests (R2= 0.2567, p<0.01 and 0.3614, p<0.01). …”
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Un service de table en bronze et argent soigneusement rangé dans une cave à Reims/Durocortorum by Michaël Brunet, Fabienne Médard, Magalie Cavé, Stéphane Sindonino

“…It was likely used for receptions and special occasions and was intended to illustrate the prosperity of its owners. The set is dated to between the end of the 2nd c. and the 3rd c. …”
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Survival in patients with CKD 3–5 after 12 months of exercise training – a post-hoc analysis of the RENEXC trial by Sara Denguir, Matthias Hellberg, Martin Almquist, Naomi Clyne

“…Trial registration ClinicalTrials.gov NCT02041156. Registration date 20,240,107.…”
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The Prevalence of Dermoscopy Use Among Dermatology Residents in Riyadh, Saudi Arabia: Cross-Sectional Study by Abdullah Almeziny, Rahaf Almutairi, Amal Altamimi, Khloud Alshehri, Latifah Almehaideb, Asem Shadid, Mohammed Al Mashali

“…Dermoscopy use is increasing worldwide, but to date, no study has documented the attitudes toward and use of dermoscopy among future dermatologists in Saudi Arabia. …”
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Effect of Medication Management at Home via Pharmacist-Led Home Televisits: Protocol for a Cluster Randomized Controlled Trial by Sheikh Rubana Hossain, Akanksha N Samant, Briana C Balsamo, Chelsea E Hawley, Michael C Zanchelli, Carolyn Zhu, Maria D Venegas, Marina Robertson, Megan B McCullough, Judith L Beizer, Kenneth S Boockvar, Albert L Siu, Lauren R Moo, William W Hung

“…The pilot phase of the study was completed December 2021 with 20 veterans and was primarily informed by the Steinman model of the prescribing process adapted to include system- and provider-level factors. The last date of enrollment was August 6, 2021. We anticipate the completion of the ongoing trial in spring 2025. …”
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Impact of estimated glomerular filtration rate (eGFR) on in-hospital mortality: an age- and HIV status-specific retrospective cohort study in Uganda by Odong Christopher, Wang Yanmei, Makabayi Emmanuel Yeko, Doreen Mary Nanyunja, Kuule Julius Kabbali

“…Patients were followed from date of admission to discharge and primary outcome was IHM. …”
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Pengembangan Aplikasi Mobile Pengisian Daya Kendaraan Listrik Sesuai Standar OCPP 1.6 by Rachmawan Atmaji Perdana, M. Nurkhoiri Hindratno, Tanzi M. Santoso, Topan Try Harmanda, Friyogi Resvy Mahda, Yahya Andreas Lapian, Monica Dwi W. S., Dionysius Aldion Renata, Prasetyo Aji, Meidy Layooari, Kusnanda Supriatna, Rully Kusumajaya, Mohammad Hamdani

“…SONIKApp is also connected in real-time to the SPKLU management system based on the OCPP 1.6 standard so that the data presented in the application is always up-to-date. This application is developed with the React Native front-end framework, so it can run on both Android and iOS operating systems. …”
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Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. by Abhishek Bhatia, Alexander J Preiss, Xuya Xiao, M Daniel Brannock, G Caleb Alexander, Robert F Chew, Hannah Davis, Megan Fitzgerald, Elaine Hill, Elizabeth P Kelly, Hemalkumar B Mehta, Charisse Madlock-Brown, Kenneth J Wilkins, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily R Pfaff, N3C Consortium

“…Treatment was defined as receipt of a Paxlovid prescription within 5 days of the patient's COVID-19 index date (positive test or diagnosis). To emulate randomization, we used the clone-censor-weight technique with inverse probability of censoring weights to balance a set of covariates including sex, age, race and ethnicity, comorbidities, community well-being index (CWBI), prior healthcare utilization, month of COVID-19 index, and site of care provision. …”
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Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial by Ali Kendal Oğuz, Celaleddin Soyalp, Yunus Emre Tunçdemir, Arzu Esen Tekeli, Nureddin Yüzkat

“…Trial registration Clinical Trials ID is NCT05674201 Date 2022.12.07.…”
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Peer- and community-led responses to HIV: A scoping review. by George Ayala, Laurel Sprague, L Leigh-Ann van der Merwe, Ruth Morgan Thomas, Judy Chang, Sonya Arreola, Sara L M Davis, Aditia Taslim, Keith Mienies, Alessandra Nilo, Lillian Mworeko, Felicita Hikuam, Carlos Garcia de Leon Moreno, José Antonio Izazola-Licea

“…The COVID-19 pandemic threatens to further slow momentum made to date. The purpose of this paper is to review available evidence on the comparative advantages of community-led HIV responses that can better inform policy making towards getting the world back on track.…”
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Painting a portrait: Analysis of national health survey data for cancer genetic counseling by Monica H. Stamp, Ora K. Gordon, Christopher P. Childers, Kimberly K. Childers

“…Research describing the epidemiology of cancer genetic counseling has mainly focused on isolated populations, a single gender (women) and a single condition (hereditary breast and ovarian cancer). Study findings to date are contradictory, making it unclear what, if any, disparities in receipt of cancer genetic counseling exist. …”
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Utilization and quality of primary and specialized palliative homecare in nursing home residents vs. community dwellers: a claims data analysis by Juliane Poeck, Franziska Meissner, Bianka Ditscheid, Markus Krause, Ulrich Wedding, Cordula Gebel, Ursula Marschall, Gabriele Meyer, Werner Schneider, Antje Freytag

“…Trial registration German Clinical Trials Register (DRKS): [DRKS00024133, Date of registration: 28.06.2021].…”
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