Prolonged pain-to-balloon time still impairs midterm left ventricular function following STEMI by Dominik Felbel, Sabrina Fackler, Rachel Michalke, Michael Paukovitsch, Matthias Gröger, Mirjam Keßler, Nicoleta Nita, Yannick Teumer, Leonhard Schneider, Armin Imhof, Dominik Buckert, Wolfgang Rottbauer, Sinisa Markovic

“…This study evaluates the proportion of impaired left ventricular ejection fraction (LVEF) following STEMI in the context of current healthcare settings at a tertiary care center equipped with the most advanced and up-to-date standards of care. Methods Patients experiencing STEMI as their first manifestation of coronary artery disease were analyzed, as these individuals had no prior experience with heart-related chest pain. …”
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Wound-healing activity of solvent fractions and antiinflammatory activity of crude extract and solvent fractions of Acokanthera schimperi Schweinf (Apocynaceae) leaves in mice mode... by Workineh Woldeselassie Hammeso, Tesfaye Yimer, Getnet Tadege, Wakuma Wakene Jifar, Dejen Nureye

“…Nothing has been published to date on the anti-inflammatory properties of A. schimperi leaves or the wound-healing effects of solvent fractions, despite a report on the crude extract's ability to heal wounds being available in the literature. …”
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Direct superior approach versus posterolateral approach in mid-term clinical outcomes of total hip arthroplasty: a prospective randomized controlled study by Zhanqi Wei, Yiming Xu, Wei Zhu, Xisheng Weng, Bin Feng

“…Trial registration The study protocol was registered on Chinese Clinical Trial Register (ChiCTR) with the register number ChiCTR2000041186 (registration date: 2020/12/21).…”
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Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response by Jing Wang, Jin Wang, Yi-Na Wang, Yuan-Yuan Wang, Wen-Juan Bai, Nai-Jun Miao

“…As a microtubule-targetting drug, vinblastine (VBL) has been used in chemotherapy. However, no study to date has explored the effect of VBL on TAM shape changes and its role in tumor immune response.Method We used fluorescent staining of the cytoskeleton and quantitative analysis to reveal the morphological differences between M0, M1, M2, TAM and VBL-treated TAM. …”
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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…Results will be submitted for publication in a peer-reviewed journal and presented at conferences.Trial registration The trial is registered at the WHO International Clinical Trials Registry Platform via the German Clinical Trials Register (DRKS): DRKS00016799 (date of registration: 25 April 2019). In case of important protocol modifications, trial registration will be updated. …”
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The pattern and burden of non-communicable diseases in armed conflict-exposed populations in Northeastern Nigeria by Roland I. Stephen, Jennifer A. Tyndall, Jamiu S. Olumoh, Malachy I. Okeke, Jacob A. Dunga, Tonde G. Elijah, Dillys M. Bello, Oyelola A. Adegboye, Jimmy A. Reyes

“…Background The risk of non-communicable diseases (NCDs) in conflict and post-conflict settings in Northeastern Nigeria has not been evaluated to date. As this region undergoes recovery, understanding the prevalence of NCDs, such as hypertension, diabetes, depression, and obesity, and the associated behavioral coping mechanisms, is crucial for developing tailored healthcare solutions. …”
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Hepatitis associated with immune checkpoint inhibitors-based combinations of other therapies: A real-world pharmacovigilance analysis based on the FDA adverse event reporting syste... by Zhaohui Li, Zixiang Zhou, Nan Zhang, Binhe Tian, Xiangqi Chen, Haitao Zhao, Hanping Wang

“…Abstract Background The combination regimen with immune checkpoint inhibitors (ICIs) and other therapies has been widely applied for patients with non-small-cell lung cancer (NSCLC). To date, no literature has systematically addressed the risk of hepatitis associated with the combination therapy. …”
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Probing Quantum Telecloning on Superconducting Quantum Processors by Elijah Pelofske, Andreas Bartschi, Stephan Eidenbenz, Bryan Garcia, Boris Kiefer

“…These results present one of the largest and most comprehensive noisy intermediate-scale quantum computer experimental analyses on (single qubit) quantum telecloning to date. The clone fidelity sharply decreases to 0.5 for <inline-formula><tex-math notation="LaTeX">$M &gt; 5$</tex-math></inline-formula>, but for <inline-formula><tex-math notation="LaTeX">$M=2$</tex-math></inline-formula>, we are able to achieve a mean clone fidelity of up to 0.79 using dynamical decoupling.…”
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Mammography Among Women Residing in Urban Versus Rural Utah: Breast Cancer Survival by Quinn Tanner, Chun‐Pin Chang, Karen Curtin, James VanDerslice, Lisa Gren, Vikrant Deshmukh, Michael Newman, Ankita Date, Mark Dodson, N. Lynn Henry, Mia Hashibe

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The effects of magnitude of calcium decline at the onset of lactation on serotonin dynamics and the serotonin-calcium axis by M.K. Connelly, R.M. Rodney, J. Kuehnl, J.P.N. Andrade, F. Sonnewend Andrade, S. Henschel, E. Block, I.J. Lean, L.L. Hernandez

“…. >2) to ensure equal parity number across the experiment, previous 305 d milk yield, and expected parturition date and randomly allocated to positive (+120 mEq/kg; +DCAD) or negative (−120 mEq/kg; −DCAD) DCAD diets from 251 d of gestation until parturition (n = 16/diet). …”
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The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…Other key symptoms include cognitive impairment and unrefreshing sleep, with many experiencing pain. To date there is no complete understanding of the triggering pathomechanisms of disease, and no quantitative biomarker available with sufficient sensitivity, specificity, and adoptability to provide conclusive diagnosis. …”
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Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort) by Gilles Wandeler, Samuel Bosomprah, Cleophas Chimbetete, Belinda Varaidzo Chihota, Guy Muula, Carolyn Bolton-Moore, Tinei Shamu, Ardele Mandiriri, Esau Banda

“…PLWOH were recruited from the same neighbourhoods and had similar socioeconomic conditions as PLWH.Findings to date Between August 2019 and March 2023, we included 1100 adults, of whom 618 (56%) were females and 539 (49%) were PLWH. …”
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Inequalities in household overcrowding in an ethnically diverse urban population: a cross-sectional study using linked health and housing records by Marta Wilk, Gill Harper, Silvia Liverani, Nicola Firman, Paul Simon, Carol Dezateux

“…After adjusting for household ethnicity and housing tenure, households with children were more likely to be overcrowded (aOR [95% CI] 5.54 [5.40-5.68] and had 22.61m2 (95%CI: -22.75,-22.46) less space per person than those without children. Conclusions Up-to-date estimates of household overcrowding measured by bedroom and space standards can be derived from linked housing and health records. …”
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A 32-year trend analysis of lower respiratory infections in children under 5: insights from the global burden of disease study 2021 by Yan Wang, Ruiyang Han, Xiao Ding, Junli Chen, Wenjia Feng, Chunping Wang, Runguo Gao, Anning Ma, Anning Ma

“…This study aims to provide an up-to-date assessment of the global burden of lower respiratory infections in children under 5 years of age.MethodsThis study utilizes data and methodologies from the Global Burden of Disease Study 2021 to analyze changes in the burden of lower respiratory infections from 1990 to 2021, focusing on incidence, mortality, and disability-adjusted life years. …”
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Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human by Fleur Zwanenburg, Thomas A. Bos, Arend D. J. Ten Harkel, Monique C. Haak, Nathan D. Hahurij, Robert E. Poelmann, Conny J. van Munsteren, Lambertus J. Wisse, Nico A. Blom, Marco C. DeRuiter, Monique R. M. Jongbloed

“…Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking. …”
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The role of the Global Observatory in addressing Gender Based Violence in Sport+ by Hayley Truskewycz, Lombe Mwambwa

“…The Global Observatory contributes to gender equality efforts in PEPAS by facilitating coordination across movements and stakeholders (De Soysa & Zipp, 2019) who often work on similar aims but often in disparate sites. Results: To date, the Global Observatory has responded to the urgent need to take action to overcome gender inequalities and drive action to address gender-based violence in sport through a range of outputs and with varying results. …”
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Examining the Effects of Construction Project Delays on Costs from the Perspective of Stakeholders Using a System Dynamics Approach: Insights from a Commercial Complex Project in Q... by Amirhosein Saffarinia, Hamidreza Yazdani

“…The project schedule is established and approved after signing the contract and designing the plans, however, most of the project managers cannot complete the project on time and projects often overrun their scheduled completion dates. Generally speaking, the project is "delayed". …”
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Farmers’ perceptions of climate change, long-term variability and trends in rainfall in Apac district, northern Uganda by Francis Atube, Geoffrey M. Malinga, Martine Nyeko, Daniel M. Okello, Basil Mugonola, George William Omony, Ipolto Okello-Uma

“…Although the September, October and November (SON) season did not show a significant abrupt change, there was a significant (p < 0.05) increase in rainfall above the upper limit from 1994 to date. Conclusion The mean seasonal rainfall for MAM and SON cropping seasons in Apac district were highly variable from different time points within the past 39 years (1980–2019), while June, July, and August (JJA) did not realize a significant change in rainfall within the same study period that the two cropping seasons (MAM and SON) in the district experienced remarkable variations in rainfall. …”
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ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 Inversely Regulates Programmed Death-Ligand 1 Through Negative Feedback of Phosphorylated Epithelial Growth Factor Recept... by Chiba N, Menju T, Shimazu Y, Toyazaki T, Sumitomo R, Miyamoto H, Tamari S, Nishikawa S, Date H

“…Naohisa Chiba,1 Toshi Menju,1 Yumeta Shimazu,1 Toshiya Toyazaki,1 Ryota Sumitomo,1 Hideaki Miyamoto,1 Shigeyuki Tamari,1,2 Shigeto Nishikawa,1 Hiroshi Date1 1Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 2Department of Thoracic Surgery, Shizuoka City Shizuoka Hospital, Shizuoka, JapanCorrespondence: Toshi Menju, Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shigoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, Tel +81-757514975, Email toshimnj@kuhp.kyoto-u.ac.jpBackground: Signaling pathways centered on the G-protein ADP-ribosylation factor 6 (Arf6) and its downstream effector ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 (AMAP1) drive cancer invasion, metastasis, and therapy resistance. …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. Extract data on outcome measures such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). …”
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