CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…The CD47-SIRPα axis has become an important target for cancer immunotherapy. To date, the advancement of CD47-targeted modalities is hindered by the ubiquitous expression of the target, often leading to rapid drug elimination and hematologic toxicity including anemia. …”
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Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework by Henry Komakech, Shatha Elnakib, Lama Bou Karroum, Evelyn Nyachwo, Winnie Adoch, Sarah Sali, Godfrey Goddie Okeny, Christopher Garimoi Orach

“…Results Uganda’s experience with the integration of refugee’s dates to 1999 when the country first implemented the Self-reliance strategy. …”
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Blood-based DNA methylation markers for lung cancer prediction by Marc Chadeau-Hyam, Paolo Vineis, Caroline Relton, Mattias Johansson, Gianluca Severi, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugué, Florence Guida, Mikael Johansson, Torkjel Sandanger, Justina Ucheojor Onwuka, Ryan Langdon, Therese Haugdahl Nøst, Hilary A. Robbins, Matthew Suderman

“…The study was restricted to participants with a history of smoking, and one control was individually matched to each lung cancer case using incidence density sampling by cohort, sex, date of blood collection, age and smoking status. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…However, those have yet to be explored aiding diagnosis for tumours of the central nervous system (CNS) other than high-grade gliomas (HGG). No up-to-date systematic review exists reporting the major surgical outcomes and diagnostic accuracy. …”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…Dysfunction and apoptosis in immune cells result from the exposure to continuous tumor-related antigen stimulation and coinhibitory signals. To date, key factors pointing to the restriction of NB-specific CD8+ T cells remain elusive. …”
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Aetiological research on the health of migrants living in Germany: a systematic literature review by Oliver Razum, Florian Fischer, Ina Danquah, Claudia Hövener, Patricia Nayna Schwerdtle, Tracy Bonsu Osei, Isabel Mank, Raissa Sorgho

“…The main objective was to systematically identify, evaluate and synthesise population-based studies that investigated exposure–outcome relationships among migrant groups in Germany.Methods In November 2019, we searched PubMed and LIVIVO, and updated this search in November 2020, to identify peer-reviewed publications that fulfilled our eligibility criteria: English or German language; study on disease aetiology among major migrant groups in Germany, according to the latest microcensus; publication date from inception to 01 November 2020 and observational or experimental study designs. …”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…Data were collected through standardised questionnaires that, in addition to sociodemographic and economic data, collected information on breast feeding, mental health status and COVID-19.Findings to date Results from the first wave show that the majority of participants have 9–11 years of schooling (54.4%; 95% CI 61.0 to 70.9) and are of mixed race (71.5%; 95% CI 66.5 to 76.0). …”
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Development and validation of predictive models of early immune effector cell–associated hematotoxicity by Emily C. Liang, Jennifer J. Huang, Andrew J. Portuguese, Valentín Ortiz-Maldonado, Aya Albittar, Natalie Wuliji, Ryan Basom, Yein Jeon, Qian Wu, Aiko Torkelson, Delaney Kirchmeier, Abigail Chutnik, Barbara Pender, Mohamed Sorror, Joshua A. Hill, Noam E. Kopmar, Rahul Banerjee, Andrew J. Cowan, Damian Green, Ajay K. Gopal, Christina Poh, Mazyar Shadman, Alexandre V. Hirayama, Brian G. Till, Erik L. Kimble, Lorenzo Iovino, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Filippo Milano, Cameron J. Turtle, David G. Maloney, Jordan Gauthier

“…Abstract: Immune effector cell–associated hematotoxicity (ICAHT) is associated with morbidity and mortality after chimeric antigen receptor (CAR) T-cell therapy. To date, the factors associated with ICAHT are poorly characterized, and there is no validated predictive model of ICAHT as defined by current consensus criteria. …”
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A Method for Quantifying Mung Bean Field Planting Layouts Using UAV Images and an Improved YOLOv8-obb Model by Kun Yang, Xiaohua Sun, Ruofan Li, Zhenxue He, Xinxin Wang, Chao Wang, Bin Wang, Fushun Wang, Hongquan Liu

“…Image detection performance and seedling information were analyzed considering various dates, heights, and resolutions, and the K-means algorithm was utilized to cluster feature points and extract row information. …”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…To date, no specific treatments have been developed for high-salt-induced hypertensive vascular damage, emphasizing the need to elucidate its underlying molecular mechanisms for therapeutic innovation. …”
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Impact of same-day ART initiation on medical care and medication discontinuation among patients with incident HIV infection or AIDS in Taiwan: A population-based cohort study by Chen-Han Chueh, Hsiao-Jou Yu, Yu-Wen Wen, Ming-Neng Shiu, Yi-Ying Chen, Shao-Chin Chiang, Yi-Wen Tsai

“…We defined care discontinuation as having no clinical visits for over 90 days since the last clinical visit and medication discontinuation as failing to pick up medication 30 days after the expected medication pick-up date. We used a doubly robust weighted Cox regression model to estimate the average hazard ratio for same-day ART initiation compared to rapid ART initiation within 7 days over a 12-month care- and medication-discontinuation risk horizon. …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…The findings will be published in a peer-reviewed journal, including positive, negative and inconclusive results.Trial registration number NCT04730037.Protocol version This paper was written per the study protocol V.4.0, dated 29 January 2021.…”
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Unraveling the individual and interactive effects of climate and competition on branch growth dynamics in Pinus koraiensis in Northeast China by Xuehan Zhao, Zheng Miao, Zheng Miao, Fengri Li, Fengri Li, Yuanshuo Hao, Yuanshuo Hao, Yumeng Jiang, Lihu Dong, Lihu Dong

“…IntroductionThe quantitative modeling of dynamic branch growth in Korean pine (Pinus koraiensis) and the analysis of the factors influencing branch growth are essential prerequisites for making scientifically sound management decisions in Korean pine plantations. To date, the effects of competition, climate and their interactions on branch growth have been insufficiently investigated. …”
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The multi-omics signatures of telomere length in childhood by Congrong Wang, Dries S. Martens, Mariona Bustamante, Rossella Alfano, Michelle Plusquin, Lea Maitre, John Wright, Rosemary R. C. McEachan, Johanna Lepeule, Remy Slama, Marina Vafeiadi, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Hector Keun, Eva Borràs, Eduard Sabidó, Angel Carracedo, Georgia Escarami, Augusto Anguita-Ruiz, Dolors Pelegrí-Sisó, Juan R. Gonzalez, Martine Vrijheid, Tim S. Nawrot

“…Abstract Background Telomere length is an important indicator of biological age and a complex multi-factor trait. To date, the telomere interactome for comprehending the high-dimensional biological aspects linked to telomere regulation during childhood remains unexplored. …”
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Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and... by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

“…However, studies on other pathogenic mycobacteria remain very much confined to local and dispersed scales. To date, the role of LULC change effects has not been adequately studied for many human and animal pathogens, and more research and attention to this issue is clearly needed. …”
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Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

“…After accounting for the random effects of the individual workers and working dates (evaluated per occupation) as well as the fixed effects of the determinants and their pairwise interaction terms (p < 0.001), we found that all four of the determinants significantly differed in their associated levels of BC exposure. …”
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Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…As of December 2023, it encompasses all viral load testing from 24 healthcare facilities in two districts of Lesotho.Findings to date From January 2016 to December 2023, 137 660 viral load test results were available for 29 380 participants. …”
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Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial by Patrick WHE Vriens, Edith M Willigendael, Maarten A Lijkwan, Friedo W Dekker, Chava L Ramspek, Michiel W de Haan, Çaĝdaş Ünlü, Boudewijn DC Heggen, Koen E A van der Bogt, Marc H Hemmelder, Mickaël J C Hiligsmann, Magda M van Loon, Joris I Rotmans, Jan H M Tordoir, Geert Willem H Schurink, Maarten G J Snoeijs, Marijke J Molegraaf, Philippe WM Cuypers, Denise Nio, Cora H Arts, Jacobien C Verhave, Goos D Laverman, Aron S Bode, Marcel C Weijmer, Bas Govaert, Aaltje Y Adema, Gijs MJM Welten, Michel MPJ Reijnen, Marc JH Groeneveld, Hans S Brink, Jeroen B van der Net, Arno Kuijper, Hilde PE Peters, Roos C van Nieuwenhuizen, Rombout R Kruse, Yvonne C Schrama, Karina A de Groot, Karima Farhat

“…The results will be disseminated through peer-reviewed publications and will be implemented in clinical practice guidelines.Trial registration number NL7933.Protocol version and date V.5, 25 February 2021.…”
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The Sunburst Arc with JWST. III. An Abundance of Direct Chemical Abundances by Brian Welch, T. Emil Rivera-Thorsen, Jane R. Rigby, Taylor A. Hutchison, Grace M. Olivier, Danielle A. Berg, Keren Sharon, Håkon Dahle, M. Riley Owens, Matthew B. Bayliss, Gourav Khullar, John Chisholm, Matthew Hayes, Keunho J. Kim

“…This study represents the most complete chemical abundance analysis of an individual H ii region at Cosmic Noon to date, which enables direct comparisons between local H ii regions and those in the distant Universe.…”
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Evidence mapping and overview of systematic reviews of the effects of acupuncture therapies by Yuqing Zhang, Gordon Guyatt, Lin Wang, Hao Wen, Liming Lu, Gabriel Rada, Lai Wang, Shuqi Ge, Yu Dong, Camila Ávila, Xiaorong Tang, Neng-Gui Xu, Zhao Zeng, Camilo Vergara, Rouhao Chen, Xiaojing Wei, Wen Luo, Jing chun Zeng, Chun-Zhi Tang

“…And we also searched for newly published RCTs that were eligible for selected best SRs in PubMed, Medline, Cochrane Central Register of Controlled Trials, Embase and four Chinese electronic databases from its lasted search dates to November 2020.Synthesis of results We reanalysed the selected MAs if new primary studies were added. …”
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