Vaginal progesterone as luteal phase support in natural cycle frozen-thawed embryo transfer (ProFET): protocol for a multicentre, open-label, randomised controlled trial by Kenny A Rodriguez-Wallberg, Christina Bergh, Ali Khatibi, Annika Strandell, Mats Brännström, Caroline Stadelmann, Kristbjörg Heiður Olsen, Margareta Kitlinski, Susanne Liffner, Eva Lundborg, Göran Westlander, Gabriella Widlund, Åsa Magnusson

“…Introduction Vaginal progesterone supplementation is frequently given to patients receiving frozen embryo transfer (FET) in the natural cycle aiming to increase the chance of pregnancy and live birth. To date, only a few studies have investigated if progesterone supplementation is beneficial in these cycles and the level of evidence for progesterone supplementation is very low.Methods and analysis The ProFET trial is a multicentre, open-label, randomised controlled trial powered for this investigation, including 1800 women with regular menstrual cycles (24–35 days), aged 18–43 years planned for natural cycle-FET receiving a single blastocyst for transfer. …”
Get full text

Self-efficacy instruments for individuals with coronary artery disease: a systematic review protocol by Karolinne Souza Monteiro, Jose Alexandre Barbosa Almeida, Rêncio Bento Florêncio, Darllane Azevedo Lemos, Jéssica Costa Leite, Lucien Peroni Gualdi

“…Studies assessing measurement properties of cardiac self-efficacy instruments for individuals with CAD will be included. No date or language restrictions will be applied to the search. …”
Get full text

Leveraging airborne imaging spectroscopy and multispectral satellite imagery to map glacial sediment plumes in Kachemak Bay, Alaska by L. Hartl, C. Schmitt, M. Stuefer, J. Jenckes, B. Page, C. Crawford, G. Schmidt, R. Yang, R. Hock

“…This informs the subsequent analysis of a homogenized, Rayleigh corrected time series of Landsat and Sentinel-2 images and seasonal patterns of turbidity.New Hydrological Insights for the RegionOur results provide the most comprehensive data set on water surface turbidity in Kachemak Bay to date and improve understanding of spatial and seasonal variability of glacial turbidity in a data sparse region. …”
Get full text

Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciproc... by Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng

“…However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses. To date, little is known about the role of EBI3 in tumor microenvironment. …”
Get full text

Footcare knowledge and practice among diabetic patients attending primary health care centers in Jazan region, Saudi Arabia by Gasem Darraj, Mohammed Somaili, Samy Shaban, Mohammed Jahlan, Abdulaziz Darraj, Banan Ahmed, Gasem Mojamamy, Mohammed Darraj, Hesham Dahlan, Ahmad Alqassim

“…The mean duration of their diabetes mellitus (DM) to date was 9.2 years, and 63% had complications of diabetes. …”
Get full text

Systematic review and meta-analysis of propranolol in the prevention and treatment of post-traumatic stress disorder by Haipeng Li, Zhengrong Zhang, Shaojie Yang, Guoqi Zhu

“…ObjectiveThis systematic review and meta-analysis aim to comprehensively evaluate the efficacy of propranolol in the prevention and treatment of post-traumatic stress disorder (PTSD), with a focus on its improvement of core PTSD symptoms.MethodsA literature search was conducted across multiple databases (including PubMed, Cochrane, Web of Science, and Embase), with the search cutoff date in October 2024. The studies included randomized controlled trials (RCTs) investigating pharmacological treatments for PTSD. …”
Get full text

Potato resistance to quarantine diseases by A. V. Khiutti, O. Yu. Antonova, N. V. Mironenko, T. A. Gavrilenko, O. S. Afanasenko

“…The review provides information on the harmfulness of S. endobioticum and PGN. To date, 43 pathotypes of S. endobioticum and 5 pathotypes of PGN have been revealed in the world. …”
Get full text

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia by David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

“…In this review, focusing on in vivo animal studies, we will specifically discuss the utilization of SZ animal models and the various methods employed to assess animal behaviour before summarising the evidence obtained to date in the field of mGluR2/3 PAMs. By doing so, we aim to deepen our understanding of the underlying mechanisms and the potential efficiency of mGluR2/3 PAMs in treating SZ. …”
Get full text

Determination of reproductive properties of virulent and vaccine classical swine fever virus strains in primary and continuous cell cultures by I. S. Kolbin, A. S. Igolkin, V. L. Gavrilova, O. S. Puzankova, Ye. V. Aronova, A. A. Yelsukova, N. N. Vlasova

“…Hence, the disease surveillance and eradication require highly sensitive methods for early diagnosis of the infection and for tests for the virus circulation in the environment.  Development of up-to-date  diagnostic methods is based on well-established  virus cultivation system; therefore, CSF virus reproduction enhancement,  tests of new cell lines without  endogenous  contamination  for their possible use are still of current importance. …”
Get full text

Risk Factors for Chronic Mastitis in Morocco and Egypt by Hanna N. Oltean, Amr S. Soliman, Omar S. Omar, Tamer F. Youssef, Mehdi Karkouri, Azza Abdel-Aziz, Ahmad Hablas, Taylor Blachley, Ali Tahri, Sofia D. Merajver

“…This is the largest case-control study reported to date on risk factors for chronic mastitis. Our study highlights distinct reproductive risk factors for the disease. …”
Get full text

Comparative analysis of allele frequencies for DNA polymorphisms associated with disease and economically important traits in the genomes of Russian and foreign cattle breeds by A. V. Igoshin, G. A. Romashov, E. N. Chernyaeva, N. P. Elatkin, N. S. Yudin, D. M. Larkin

“…The genetic makeup of a breed including its genetic differences from other breeds determines its appearance and characteristics, including economically important traits and resistance to pathologies. To date, many loci controlling significant phenotypes have been identified, which is successfully used in the world practice of marker-assisted selection to improve breed properties. …”
Get full text

Dynamic switching between brain networks predicts creative ability by Qunlin Chen, Yoed N. Kenett, Zaixu Cui, Hikaru Takeuchi, Andreas Fink, Mathias Benedek, Daniel C. Zeitlen, Kaixiang Zhuang, James Lloyd-Cox, Ryuta Kawashima, Jiang Qiu, Roger E. Beaty

“…Employing a meta-analytic network neuroscience approach, we analyze resting-state fMRI and creative task performance across 10 independent samples from Austria, Canada, China, Japan, and the United States (N = 2433)—constituting the largest and most ethnically diverse creativity neuroscience study to date. Using time-resolved network analysis, we investigate the relationship between creativity (i.e., divergent thinking ability) and dynamic switching between DMN and ECN. …”
Get full text

Urdu Handwritten Characters Data Visualization and Recognition Using Distributed Stochastic Neighborhood Embedding and Deep Network by Mujtaba Husnain, Malik Muhammad Saad Missen, Shahzad Mumtaz, Dost Muhammad Khan, Mickäel Coustaty, Muhammad Muzzamil Luqman, Jean-Marc Ogier, Hizbullah Khattak, Sikandar Ali, Ali Samad

“…We performed three tasks in a disciplined order; namely, (i) we generated a state-of-the-art dataset of both the Urdu handwritten characters and numerals by inviting a number of native Urdu participants from different social and academic groups, since there is no publicly available dataset of such type till date, then (ii) applied classical approaches of dimensionality reduction and data visualization like Principal Component Analysis (PCA), Autoencoders (AE) in comparison with t-Stochastic Neighborhood Embedding (t-SNE), and (iii) used the reduced dimensions obtained through PCA, AE, and t-SNE for recognition of Urdu handwritten characters and numerals using a deep network like Convolution Neural Network (CNN). …”
Get full text

Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) by Landon Myer, Amy L Slogrove, Ushma Mehta, Mary-Ann Davies, Max Kroon, Greg Petro, Alexa Heekes, Andrew Boulle, Karen Fieggen, Chantal Stewart, Ayesha Osman, Natasha Rhoda, Emma Kalk, Florence Phelanyane, Jonathan Euvrard, Stefan Gebhardt, Kim Anderson

“…This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set.Findings to date Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. …”
Get full text

Genetic Diversity and Structure of a Critically Endangered Ornamental Species, <i>Rhododendron farinosum</i>, with Extremely Small Populations by Fengjuan Li, Linyuan Fan, Jingli Zhang, Wen Liu, Wei Li, Yongpeng Ma, Hong Ma

“…Furthermore, the effective population size of <i>R. farinosum</i> was inferred to date back to 95,000 years ago using the stairway plot, with a continuous decline from 3292 years. …”
Get full text

Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also be totally asymptomatic. To date, over 1400 mutations have been linked to HCM, mostly in genes encoding for sarcomeric proteins. …”
Get full text

A Novel Back‐Calculation Approach to Estimate Ocean Anthropogenic Carbon Using Carbon‐Based Data and a Total Matrix Intercomparison Method by M. López‐Mozos, F. F. Pérez, L. I. Carracedo, G. Gebbie, A. Velo

“…No single optimal BC method exists to date for computing Cant; therefore, it is necessary to continue advancing the broad range of approaches. …”
Get full text

Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature by Federico Cappellacci, Fabio Medas, Gian Luigi Canu, Maria Letizia Lai, Giovanni Conzo, Enrico Erdas, Pietro Giorgio Calò

“…Diagnosis of parathyroid carcinoma in tertiary hyperparathyroidism is remarkably complex because of the lack of clinical diagnostic criteria and, in many cases, is made postoperatively at histopathological examination. Conclusion. To date, radical surgery represents the mainstay of treatment, with a five- and ten-year survival rates overall acceptable.…”
Get full text

A Chemically Defined Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Yajun Zhao, E. Xiao, Wanqi Lv, Xian Dong, Linhai He, Yixiang Wang, Yi Zhang

“…Previous studies demonstrated that spheroid formation of MSCs exhibited improved stemness maintenance and therapeutic potential compared with monolayer culture. To date, various spheroid culture systems have been developed but most of them required low adhesion conditions or special equipment. …”
Get full text

Detection and Monitoring of Damage Status and Infestation by Spodoptera frugiperda in Maize Crops in Luxor Region, Egypt by Moustafa Mohamed Sabry Bakry, Thuraya A.A. M. Al-Saadi, Dalal M. Aljedani, N. F. Abdel-Baky, Lamiaa H.Y. Mohamed

“…We conducted this study to monitor and determine the damage status and infestation frequency of S. frugiperda on maize plants in Luxor Governorate, southern Egypt. The sampling date was set with the first observable occurrence of fall armyworm at the study site. …”
Get full text