Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism by Lucia Ciccoli, Claudio De Felice, Eugenio Paccagnini, Silvia Leoncini, Alessandra Pecorelli, Cinzia Signorini, Giuseppe Belmonte, Roberto Guerranti, Alessio Cortelazzo, Mariangela Gentile, Gloria Zollo, Thierry Durand, Giuseppe Valacchi, Marcello Rossi, Joussef Hayek

“…Although red blood cells (RBCs) membrane lipidomics and rheological variables have been reported to be altered, with some suggestions indicating an increased lipid peroxidation in the erythrocyte membrane, to date no information exists on how the oxidative membrane damage may affect cytoskeletal membrane proteins and, ultimately, RBCs shape in autism. …”
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SQUARE-IT: a proposed approach to square the identified research problem in the literature with the objectives, the appropriate clinical research question, and the research hypothe... by Martin Alfuth, Jonas Klemp, Annette Schmidt, Lukas Streese, Nikolai Ramadanov, Robert Prill

“…Before formulating the focused clinical question, SQUARE-IT can be used as a preparatory step to enable researchers to organize the relevant information that has been explored to date and to assess whether additional information is needed, thereby identifying current research gaps. …”
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Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain by Anton Pikhovych, Nina Paloma Stolberg, Lea Jessica Flitsch, Helene Luise Walter, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

“…Transcranial direct current stimulation (tDCS) has been suggested as an adjuvant tool to promote recovery of function after stroke, but the mechanisms of its action to date remain poorly understood. Moreover, studies aimed at unraveling those mechanisms have essentially been limited to the rat, where tDCS activates resident microglia as well as endogenous neural stem cells. …”
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Tracking Outflow Using Line Locking (TOLL). II. Large Line-locking Web Identified in Quasar J151352+085555 by Chen Chen, Zhicheng He, Weimin Yi, Tuo Ji, Marie Wingyee Lau, Bo Ma

“…In the second paper of the TOLL project, we present the discovery of one of the largest “line-locking webs” known to date from the Very Large Telescope UVES spectra of QSO J151352+085555. …”
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New Treatments for Bacterial Keratitis by Raymond L. M. Wong, R. A. Gangwani, Lester W. H. Yu, Jimmy S. M. Lai

“…Large scale studies or publications at more recent dates were selected. Data Synthesis. Broad spectrum antibiotics have been the main stay of treatment for bacterial keratitis but with the emergence of bacterial resistance; there is a need for newer antimicrobial agents and treatment methods. …”
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Detection and Analysis of Burned Areas with Sentinel-2 MSI and Landsat-8 OLI: Çanakkale / Gelibolu Forest Fire by Beyza Yılmaz, Mehveş Demirel, Filiz Bektaş Balçık

“…In this study, the 6 July 2020 dated wildfire that occurred in the Gallipoli district of Çanakkale province has been analyzed by using Sentinel-2 MSI and Landsat-8 OLI satellite images. …”
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Vaccinating Adult Patients with Cirrhosis: Trends over a Decade in the United States by Abhijeet Waghray, Nisheet Waghray, Hicham Khallafi, K. V. Narayanan Menon

“…Prior studies assessing vaccination rates in patients with cirrhosis have specific limitations and to date no study has provided a comprehensive evaluation of vaccination rates in patients with cirrhosis in the United States. …”
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High-Throughput Sequencing Reveals Diverse Sets of Conserved, Nonconserved, and Species-Specific miRNAs in Jute by Md. Tariqul Islam, Ahlan Sabah Ferdous, Rifat Ara Najnin, Suprovath Kumar Sarker, Haseena Khan

“…Jute is an agroeconomically important fibre crop; nonetheless, no practical information is available for microRNAs in jute to date. In this study, Illumina sequencing revealed a total of 227 known microRNAs and 17 potential novel microRNA candidates in jute, of which 164 belong to 23 conserved families and the remaining 63 belong to 58 nonconserved families. …”
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Spatial autocorrelation and host anemone species drive variation in local components of fitness in a wild clownfish population by Marrot, Pascal, Fauvelot, Cécile, Berumen, Michael L, Srinivasan, Maya, Jones, Geoffrey P, Planes, Serge, Pujol, Benoit

“…The susceptibility of species to habitat changes depends on which ecological drivers shape individual fitness components. To date, only a few studies have quantified fitness components such as the Lifetime Reproductive Success across multiple generations in wild marine species. …”
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Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024 by Gulnur G. Gainollina, Murat K. Jakanov, Bazylbek S. Zhakiev, Uteugaly G. Karsakbayev, Kairat R. Taishibayev, Bulat A. Kurmanbayev, Bulat A. Kurmanbayev

“…The articles were assessed based on various metrics, including the number of citations, publication dates, countries of origin, institutions, journals, and authors.ResultsA total of 929 articles were identified, of which 251 were deemed suitable for analysis after duplicates were removed. …”
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Assessment of smartphone-based active distraction in association with audioanalgesia for overcoming airotor-related anxiety in children: a randomized controlled trial by Kritika Bali, Radhika Ailawadi, Y. M. Karuna, N. Srikant, Ashwin Rao, P. Anupama Nayak, Charisma Thimmaiah

“…Trial Registration Registered in the Clinical Trials Registry India (CTRI/2024/07/070160) dated 08/07/2024.…”
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Feasibility Study of an Alcohol-Based Liquid Scintillation Detector and Its Application by Byoung Chan Kim, Ji Young Choi, Kyung Kwang Joo, Seon Yeong Park, Ye Sung Song, Hee Jin Woo

“…In addition, it is very important to develop a stable liquid scintillator for particle detectors or other medical applications. To date, there have been no previous R&D studies elsewhere for the use of alcohol in particle detectors, and no market products are available of this type. …”
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Current state and development of the City park in Skopje by Jasminka Rizovska Atanasovska, Iskra Apostolovska, Nikolčo Velkovski, Vlatko Andonovski, Divna Penčić

“…It gives a review of the vegetation and other park elements, as well the state of its overall area and the changes that have occurred to date. …”
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Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis by Bruno Guedes Baldi, Paulo Henrique Ramos Feitosa, Adalberto Sperb Rubin, Alexandre Franco Amaral, Carolina Salim Gonçalves Freitas, Cláudia Henrique da Costa, Eliane Viana Mancuzo, Ellen Caroline Toledo do Nascimento, Mariana Sponholz Araujo, Marcelo Jorge Jacó Rocha, Martina Rodrigues de Oliveira, Tatiana Senna Galvão, Pedro Paulo Teixeira e Silva Torres, Carlos Roberto Ribeiro Carvalho

“…In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. To date, no Brazilian recommendations for a comprehensive approach to the disease have been published. …”
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Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…Abstract Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. …”
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A Study of Success Rate of Miniscrew Implants as Temporary Anchorage Devices in Singapore by Song Yi Lin, Yow Mimi, Chew Ming Tak, Foong Kelvin Weng Chiong, Wong Hung Chew

“…The outcome at T2 was assessed 12 months after the miniscrew’s insertion date or after its use as a temporary anchorage device has ceased. …”
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Protein Identification Improvement in Complex Samples Using Higher Frequency MS Acquisition and PEAKS Software by Arman Kulyyassov, Saya Makhsatova, Aruzhan Kurmanbay

“…However, improved identification rates can also be achieved by optimizing MS acquisition frequencies and employing advanced software, without increasing analysis time, thus maintaining the throughput of the method. To date, we found only one study in the literature examining the influence of MS acquisition frequency on protein identification, specifically using two ion trap mass spectrometer models. …”
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When to cryopreserve and when to let it go? A systematic review of priorities in wild animal cryobanking by James Edward Brereton, Sarah Louise Spooner, Susan L. Walker, Andrew Mooney, Philippe Wilson, Gabriela F. Mastromonaco, Elena Hunter, Samuel White

“…Globally, many cryobanks have been developed to preserve animal tissues for future use in wildlife conservation. However, to date, there has been no attempt to review the purpose, priorities and direction of these cryobanks. …”
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Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa by Hyuk Chan Kwon, Sup Kim, Sheng Jin, Sun-Ae Shin, Jeong Han Lee, Min Jung Park, Soo Jeong Kim, Yong-Ho Park

“…In cases of nasopharyngeal carcinoma (NPC), the auditory apparatus is inevitably exposed to radiation fields and sustains considerable damage, resulting in dysfunction. To date, little research has been conducted on the changes induced by RTx in the middle ear and the underlying mechanisms involved. …”
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New Prospects of Cytoprotection in the Treatment and Prevention of Gastric and Intestinal Diseases (Resolution of an Expert Council and Literature Review) by A. I. Martynov, A. A. Sheptulin, I. V. Mayev, A. N. Kazyulin, A. Ye. Karateev, A. V. Melekhov, L. K. Pal’gova, K. L. Raikhel’son

“…Aim. To generalize up-to-date information on the possibilities of cytoprotection in the treatment and prevention of gastric and intestinal diseases, as well as to present the materials of an Expert Council meeting held on February 8, 2020 in Moscow under the support of the Alium company.General provisions. …”
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