De novo transcriptome assembly of Aureobasidium melanogenum CGMCC18996 to analyze the β-poly(L-malic acid) biosynthesis pathway under the CaCO3 addition by Genan Wang, Haisong Yin, Tingbin Zhao, Donglin Yang, Shiru Jia, Changsheng Qiao

“…β-Poly(L-malic acid) (PMLA) is a water-soluble biopolymer used in food, medicine and other industries. To date, the biosynthesis pathway of PMLA has not been fully elucidated. …”
Get full text

A Safety Case for the Use of Bipolar ±60V DC for Microgrids by Stephen A. Jay, David Clark, Chris Stone, Renke Han, Daniel J. Rogers, Malcolm McCulloch

“…Low voltage dc microgrids are an increasingly viable option for low-volume distribution of electrical power in developing countries. 48V systems have proven popular, owing largely to familiarity from the automotive sector, but there remains to date no universal consensus on optimal system voltage. …”
Get full text

Physicochemical Characteristics of River Water Downstream of a Large Tropical Hydroelectric Dam by Teck-Yee Ling, Chen-Lin Soo, Teresa Lee-Eng Heng, Lee Nyanti, Siong-Fong Sim, Jongkar Grinang

“…Water quality in the downstream river of a hydroelectric dam may be affected by the structural design and operation. To date, little is known about the water quality downstream of the largest dam in Malaysia, the Bakun hydroelectric dam. …”
Get full text

Is It Necessary to Specifically Define the Cause of Surgically Treated Biliary Tract Infections? A Rare Case of Raoultella planticola Cholecystitis and Literature Review by Suat Can Ulukent, İnanc Samil Sarici, Nuri Alper Sahbaz, Yigit Mehmet Ozgun, Ozlem Akca, Kamuran Sanlı

“…Patients with acute cholecystitis are usually treated without any microbiological sampling and antibiotic treatment is started empirically. To date, there have only been 5 reported biliary system related R. planticola infections in humans. …”
Get full text

Unveiling an in-plane Hall effect in rutile RuO2 films by Meng Wang, Jianbing Zhang, Di Tian, Pu Yu, Fumitaka Kagawa

“…Abstract The in-plane-magnetic-field-induced Hall effect (IPHE) observed in Weyl semimetals and PT-symmetric antiferromagnets has attracted increasing attention, as it breaks the stereotype that the Hall effect is induced by an out-of-plane magnetic field or magnetization. To date, the IPHE has been discussed mainly for materials with low-symmetry crystal/magnetic point groups. …”
Get full text

Actin Alpha 2 (ACTA2) Downregulation Inhibits Neural Stem Cell Migration through Rho GTPase Activation by Ji Zhang, Xuheng Jiang, Chao Zhang, Jun Zhong, Xuanyu Fang, Huanhuan Li, Fangke Xie, Xiaofei Huang, Xiaojun Zhang, Quan Hu, Hongfei Ge, Anyong Yu

“…Although neural stem cells (NSCs) could migrate towards lesions after central nervous system (CNS) injury, the migration ability always is restricted due to the disturbed composition and density of the adhesion ligands and extracellular matrix (ECM) gradient after CNS injury. To date, various methods have been developed to enhance NSC migration and a number of factors, which are affecting NSC migration potential, have been identified. …”
Get full text

Emerging roles of extracellular vesicles in oral and maxillofacial areas by Qianting Wang, Jiayu Sun, Haci Jiang, Mengfei Yu

“…Present in various body fluids and tissues, they act as messengers via the transfer of nucleic acids, proteins, and metabolites to recipient cells. To date, studies have revealed the different roles of extracellular vesicles in physiological or pathological processes, as well as applications in disease diagnosis, prognosis, and treatment. …”
Get full text

Coupled Electrokinetics-Adsorption Technique for Simultaneous Removal of Heavy Metals and Organics from Saline-Sodic Soil by Salihu Lukman, Mohammed Hussain Essa, Nuhu Dalhat Mu'azu, Alaadin Bukhari

“…In this study, an integrated in situ remediation technique that couples electrokinetics with adsorption, using locally produced granular activated carbon from date palm pits in the treatment zones that are installed directly to bracket the contaminated soils at bench-scale, is investigated. …”
Get full text

Association between Obesity and Asthma in Preschool Mexican Children by Francisco Vázquez-Nava, Jaime Morales Romero, Arturo Córdova-Fernandez, Atenógenes H. Saldívar-González, Carlos F. Vázquez-Rodríguez, Maria del C. Barrientos-Gómez, Dolores Lin-Ochoa, Rodríguez Eliza M. Vázquez

“…The results obtained to date are debatable. We investigated the association between obesity and asthma in 1,160 preschool Mexican children. …”
Get full text

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats by Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill

“…Glucocorticoid hormones and inflammatory mediators, both of which are increased by stress, have been shown to bias tryptophan along the kynurenine pathway and away from serotonin synthesis; however, to date, there is no published data regarding the effects of stress on enzymes regulating the kynurenine pathway in a regional manner throughout the brain. …”
Get full text

Paediatric Inflammatory Bowel Disease: A Mechanistic Approach to Investigate Exclusive Enteral Nutrition Treatment by Lily Nahidi, Andrew S. Day, Daniel A. Lemberg, Steven T. Leach

“…This review will discuss recent research into EEN both describing clinical features of EEN therapy and discussing the most up-to-date understanding of the mechanisms through which EEN may be reducing intestinal inflammation and inducing disease remission.…”
Get full text

BioVars - A bioclimatic dataset for Europe based on a large regional climate ensemble for periods in 1971–2098 by Anne Reichmuth, Oldrich Rakovec, Friedrich Boeing, Sebastian Müller, Luis Samaniego, Andreas Marx, Hanna Komischke, Andreas Schmidt, Daniel Doktor

“…For this purpose, the projection must have high-quality bioclimatic variables from historical and future climatic periods for the projection. To date, there are many global bioclimatic variables on this topic. …”
Get full text

Adjunctive Therapies to Cerclage for the Prevention of Preterm Birth: A Systematic Review by Emily A. DeFranco, Amy Miyoshi Valent, Tondra Newman, Jodi Regan, Jessica Smith, Louis J. Muglia

“…We searched PubMed and Cochrane databases without date criteria with restriction to English language and human studies and performed additional bibliographic review of selected articles and identified 305 total studies for review. …”
Get full text

Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma by Gerson Geovany Andino-Ríos, Lesly Portocarrero-Ortiz, Carlos Rojas-Guerrero, Alejandro Terrones-Lozano, Alma Ortiz-Plata, Alfredo Adolfo Reza-Albarrán

“…Even rarer is the presence of a functional gonadotropinoma since only very few case reports exist to date. The conversion of a clinically silent to functional pituitary adenoma is extraordinarily rare; the mechanisms that explain these phenomena are unknown or not fully understood. …”
Get full text

Skipping Posterior Dynamic Transpedicular Stabilization for Distant Segment Degenerative Disease by Bilgehan Solmaz, Ahmet Levent Aydin, Cengiz Gomleksiz, Yaprak Ataker, Mehdi Sasani, Tunc Oktenoglu, Ali Fahir Ozer

“…Objective. To date, there is still no consensus on the treatment of spinal degenerative disease. …”
Get full text

First Principles Study of Electronic, Vibrational, Elastic, and Thermodynamic Properties of Sc‐X (X = P, S, Se) Compounds by S. K. Yadav, S. Dahal, R. Khadka, B. Guragain, P. Pokharel, P. Oli, D. Adhikari

“…ABSTRACT The available literature on Sc‐X (X = P, S, Se) compounds was comprehensively reviewed which revealed the unavailability of temperature‐dependent mechanical and thermodynamic properties of the materials to date. In this regard, the mixing properties of the compounds were investigated on the basis of density functional theory using Quantum ESSPRESSO codes. …”
Get full text

Coronavirus Host Genomics Study: South Africa (COVIGen-SA) by Andrew K. May, Heather Seymour, Harriet Etheredge, Heather Maher, Marta C. Nunes, Shabir A. Madhi, Simiso M. Sokhela, W. D. Francois Venter, Neil Martinson, Firdaus Nabeemeeah, Cheryl Cohen, Jocelyn Moyes, Sibongile Walaza, Stefano Tempia, Jackie Kleynhans, Anne von Gottberg, Jeremy Nel, Halima Dawood, Ebrahim Variava, Stephen Tollman, Kathleen Kahn, Kobus Herbst, Emily B. Wong, Caroline T. Tiemessen, Alex van Blydenstein, Lyle Murray, Michelle Venter, June Fabian, Michéle Ramsay

“…Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. …”
Get full text

Genomic analysis of three medieval parchments from German monasteries by Felix Heinrich, Henner Simianer, Jörg Bölling, Hedwig Röckelein, Christian Roos, Christian Reimer, Armin O. Schmitt

“…Finally, the genetic distances between the parchment samples show a putative association with the dates when the documents were written, indicating the usefulness of genetic analysis for provenance research.…”
Get full text

First Report of Psoriatic-Like Dermatitis and Arthritis in a 4-Year-Old Female Spayed Pug Mix by Stephanie A. Regan, Rosanna Marsella, Ibrahim Ozmen

“…Psoriasis with concurrent PsA is characterized by erythematous, silvery, scaly plaques, especially on the extremities, and concurrent arthritis with enthesitis, tenosynovitis, and dactylitis. To date, no such disease has spontaneously occurred in domestic animals. …”
Get full text

Surgical Reconstruction with the Remnant Ligament Improves Joint Position Sense as well as Functional Ankle Instability: A 1-Year Follow-Up Study by Kamizato Iwao, Deie Masataka, Fukuhara Kohei

“…However, whether surgical reconstruction improves sensorimotor control has not been reported to date. The purpose of this study was to assess functional improvement of chronic ankle instability after surgical reconstruction using the remnant ligament. …”
Get full text