Shifting the paradigm of type 1 diabetes: a narrative review of disease-modifying therapies by Alexander J. O’Donovan, Seth Gorelik, Seth Gorelik, Laura M. Nally

“…As a greater understanding of these stages of T1D have evolved, research efforts have been devoted to delaying the onset of clinical disease. To date, only one medication, teplizumab, has been approved by the Food and Drug Administration (FDA) for the treatment of stage 2 T1D. …”
Get full text

Understanding the spread of agriculture in the Western Mediterranean (6th-3rd millennia BC) with Machine Learning tools by Maria Elena Castiello, Emmanuele Russo, Héctor Martínez-Grau, Ana Jesus, Georgina Prats, Ferran Antolín

“…Here, we tackle this question by compiling data and proxies at a superregional and multi-scale level, including archaeobotanical information, radiocarbon dates and paleoclimatic models, then applying a machine learning approach to investigate the impact of ecological and climatic constraints on the first Neolithic humans and crops. …”
Get full text

Standardized Functions for Smartphone Applications: Examples from Maternal and Child Health by Mary Jane Rotheram-Borus, Mark Tomlinson, Dallas Swendeman, Adabel Lee, Erynne Jones

“…Smart phones allow information to be delivered by voice, texts, pictures, and videos as well as be triggered by location and date. Prompts and reminders, as well as real-time monitoring, can improve quality of health care. …”
Get full text

Experimental Activity with a Rover for Underwater Inspection by Erika Ottaviano, Agnese Testa, Pierluigi Rea, Marco Saccucci, Assunta Pelliccio, Maurizio Ruggiu

“…The application of such techniques can significantly improve the state of monitoring, reduce operational complexity, and partially offset the financial burden of periodic inspections. To date, there has been very little work on image-based techniques for detecting and quantifying the extent of structural damage, particularly in the submerged part of marine structures. …”
Get full text

Randomized controlled trial on the efficacy of forest walking compared to urban walking in enhancing mucosal immunity by Hiroko Ochiai, Shigeru Inoue, Gaku Masuda, Shiho Amagasa, Tomohiko Sugishita, Toshiya Ochiai, Naoko Yanagisawa, Yoshio Nakata, Michiko Imai

“…Trail registration number: UMIN000045851. Approval date: 25/10/2021.…”
Get full text

A Novel Spatio–Temporal Deep Learning Vehicle Turns Detection Scheme Using GPS-Only Data by Mussadiq Abdul Rahim, Sultan Daud Khan, Salabat Khan, Muhammad Rashid, Rafi Ullah, Hanan Tariq, Stanislaw Czapp

“…Many urban applications, such as car-sharing and logistics, rely on accurate and up-to-date road map data. Map generation methods use a variety of data sources, including but not limited to global positioning systems (GPS). …”
Get full text

Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study by Ying Tan, Juan Tan, Cheng Luo, Wenjuan Cui, Hui He, Yi Bin, Jiayan Deng, Rui Tan, Wenrong Tan, Tao Liu, Nanlin Zeng, Ruhui Xiao, Dezhong Yao, Xiaoming Wang

“…Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms. To date, many studies of PD have focused on its cardinal motor symptoms. …”
Get full text

Global stability for a mosquito-borne disease model with continuous-time age structure in the susceptible and relapsed host classes by Maria Guadalupe Vazquez-Peña, Cruz Vargas-De-León, Jorge Velázquez-Castro

“…Chronological age refers to the time elapsed from the date of birth of the host to the present time. On the other hand, asymptomatic infection age denotes the time elapsed since the host became asymptomatic after the primary infection. …”
Get full text

Cognitive Function in Parkinson’s Disease Patients with and without Anxiety by K. A. Ehgoetz Martens, J. Y. Y. Szeto, A. J. Muller, J. M. Hall, M. Gilat, C. C. Walton, S. J. G. Lewis

“…Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. …”
Get full text

Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…Patients were included if at the index date they had at least 365 days of prior observation and were not hospitalised for any reason on or within 7 days prior to the index date. …”
Get full text

State of the art of pricing policy in air transportation: network carriers vs. low-cost airlines by Christian Wehner, Jesús Manuel López-Bonilla, Luis Miguel López-Bonilla, José António C. Santos

“…This paper adds to the knowledge of this topic because it presents the most up-to-date and complete study on pricing regarding network carriers vs. low-cost airlines.…”
Get full text

Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data by Sungmin Jung, Jack Bufton, Zeqing Bao, Wonjoon Cho, Dean Aguiar, Christine Allen

“…A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide-co-glycolide) [1]. …”
Get full text

Pembrolizumab in a Patient with Treatment-Naïve Unresectable BRAF-Mutation Negative Anaplastic Thyroid Cancer by Fadi Nabhan, Elizabeth Kander, Rulong Shen, Amit Agrawal, Vineeth Sukrithan, Ye Zhou, Ashima Goyal, Katie Roll, Manisha Shah, Bhavana Konda

“…The patient has received 25 doses of pembrolizumab to date, with rapid resolution of symptoms and a significant reduction in tumor size. …”
Get full text

A Review of Fish Anomalies in Türkiye’s Waters by İsmail Reis, Sercan Yapıcı, Hasan Cerim, Özgen Yılmaz

“…It is thought that with the information provided, this review may establish an up-to-date basis for future studies.…”
Get full text

Keratoconus with two consecutive re-emergences: a case report by Peicheng Zhang, Yanchao Wu, Lixiao Ma, Dong Wang

“…Postoperative follow-up emphasized the management of chronic allergic conjunctivitis (CAC) and the correction of eye-rubbing habits. To date, he has not experienced any further re-emergence. …”
Get full text

Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin by Cory R. Hewitt, Nicholas J. Wixon, Arthur Gallegos, You Zhou, Victor C. Huber, M. Scott Killian

“…<b>Background/Objectives</b>: Zika virus (ZIKV) infection is associated with life-threatening diseases in humans. To date, there are no available FDA-approved therapies or vaccines for the specific treatment or prevention of ZIKV infection. …”
Get full text

Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis by Davood Oliaee, Mohammad Taher Boroushaki, Naiime Oliaee, Ahmad Ghorbani

“…To date, there is no report on safety of Artemisia Kopetdaghensis. …”
Get full text

Mapping Tree-Covered Forest Formations (Case Study: Beni-Mellal Forest): Evaluation Study of the Potential of the Mohammed VI-B Satellite Image by chikh Essbiti Mohammed, El Ghmari Abderrahmene, El Harti Abderrazak, Bachaoui El Mostapha, Namous Mustapha, Krimissa Samira, El Aloui Abdenbi, Hajaj Soufiane, Laouane Mourad

“…The Mohammed VI satellite imagery has a very high spatial resolution (VHR) (50 cm), which enables the study of vegetation at a very fine scale, such as the mapping of tree species. However, to date, few studies have been published on vegetation analysis using Mohammed VI satellite imagery. …”
Get full text

Technical Aspects of Laparoscopic Distal Pancreatectomy for Benign and Malignant Disease: Review of the Literature by T. de Rooij, R. Sitarz, O. R. Busch, M. G. Besselink, M. Abu Hilal

“…For decades, surgeons have tried to prevent these fistulas but to date no strategy has been confirmed to be effective in 2 consecutive randomized studies. …”
Get full text

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications by Meng Cai, Gopi K. Kolluru, Asif Ahmed

“…The aberrant microRNA expression is implicated in the disease process. To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. …”
Get full text