Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

“…HSV-1 is well known for its lytic infections at the primary sites and for establishing latency in the sensory neuronal ganglia, with occasional recurrent infections. To date, there are no approved commercially available vaccines, and anti-HSV-1 drugs such as specific or non-specific nucleotide (nucleoside) analogs and helicase-primase inhibitors have become the main clinical agents for the treatment of HSV-1 infections despite challenges from resistance. …”
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Basal Cell Ameloblastoma of Mandible: A Rare Case Report with Review by Hemant Shakya, Vikram Khare, Nilesh Pardhe, Ena Mathur, Mansi Chouhan

“…Basal cell ameloblastoma is believed to be the rarest histologic subtype in which the tumor is composed of more primitive cells and has even fewer features of peripheral palisading. Till date, only few cases of basal cell ameloblastoma have been reported in the literature. …”
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Fatal Pulmonary Embolism following Achilles Tendon Repair: A Case Report and a Review of the Literature by Asim M. Makhdom, Simon Garceau, Ronald Dimentberg

“…It can progress to a pulmonary embolism, a significant source of mortality. Up to date, patients with Achilles tendon rupture routinely do not receive DVT chemical prophylaxis. …”
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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…Gene therapy, which aims to modify or express specific proteins for neuroprotection or correction, is considered a powerful tool in managing neurodegenerative conditions. To date, antisense oligonucleotide (ASO) drugs targeting the pathological genes associated with ALS and HD have shown promising results in numerous animal studies and several clinical trials. …”
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An EMG Keyboard for Forearm Amputees by Wenwei Yu, Ryu Kato, Fukuda Fabio, Hiroshi Yokoi, Yukinori Kakazu

“…A high-efficiency, easy-to-use input device is not only important for data entry but also for human-computer interaction. To date, there has been little research on input devices with many degrees of freedom (DOF) that can be used by the handicapped. …”
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Fifty-Two-Week Results of Clinical and Imaging Assessments of a Patient with Rheumatoid Arthritis Complicated by Systemic Sclerosis with Interstitial Pneumonia and Type 1 Diabetes... by Yuya Fujita, Masao Nawata, Atsushi Nagayasu, Kazuki Someya, Kazuyoshi Saito, Yoshiya Tanaka

“…Regarding the influence on type 1 diabetes, the required daily dose of insulin and hemoglobin A1c (HbA1c) levels decreased. To date, no studies have demonstrated the effectiveness of baricitinib on systemic sclerosis or type 1 diabetes. …”
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Research progress and application prospects of flexible wearable sensor in spacesuit by Aiming Bu, Wanxin Zhang, Qian Ran, Dongyue Liu, Jialu Ma, Rongqing Wang, Kun Shang, Hongrui Yang, Zhiqiang Mei

“…It can realize the benefits of heart rate, breathing, sweat, action recognition and date acquisition, etc. The joint resistance characteristics of spacesuit is revealed under pressure were studied by wearing flexible wearable sensors, which provides a theoretical basis for improving the performance of spacesuit. …”
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The Role of Dexmedetomidine in Pediatric Patients Presenting with an Anticholinergic Toxidrome by Mitchell Zekhtser, Erin Carroll, Molly Boyd, Shashikanth Ambati

“…We report two pediatric cases of anticholinergic toxidrome, including the youngest reported to date, in which standard therapeutic strategies were either contraindicated or ineffective, while treatment with dexmedetomidine was rapidly efficacious with no adverse effects. …”
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Pancytopenia in a Patient with Rendu-Osler-Weber Syndrome and Uncommon Vascular Abnormalities by Nicolò Binello, Antonio Gasbarrini, Eleonora Gaetani

“…Splenic artery aneurysms are extremely uncommon in HHT as only anecdotal cases have been reported to date. However, we believe that the aneurysm critically contributed to the progression of splenomegaly and the development of pancytopenia.…”
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Orbital Cystic Schwannoma Originating from the Frontal Nerve by Yasuhiko Hayashi, Takuya Watanabe, Daisuke Kita, Yutaka Hayashi, Masayuki Takahira, Jun-ichiro Hamada

“…Intraorbital cystic schwannomas originating from the frontal nerve are even rarer, with only 1 case reported to date. This is most likely due to the fact that, in most cases, the origin of the orbital schwannoma cannot be identified intraoperatively. …”
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Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes by Lisa M. Bramer, Ernesto S. Nakayasu, Javier E. Flores, Jennifer E. Van Eyk, Michael J. MacCoss, Hemang M. Parikh, Thomas O. Metz, Bobbie-Jo M. Webb-Robertson

“…Comprised of 6,426 plasma analyses, The Environmental Determinants of Diabetes in the Young (TEDDY) proteomics validation study constitutes one of the largest targeted proteomics experiments in the literature to date. The proteomics data from this study were generated over the course of 2.5 years from over 900 study subjects, each providing up to 29 longitudinal samples. …”
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Axion-like relics: new constraints from old comagnetometer data by Itay M. Bloch, Yonit Hochberg, Eric Kuflik, Tomer Volansky

“…We show that the decade-old experimental data place the most stringent terrestrial constraints to date on ultra-light axion-like particles coupled to neutrons. …”
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Jadassohn-Lewandowsky syndrome. Report of the first pediatric case in Cuba by Migdalis Hidalgo Muñiz, Aracelis Hernández García, Andrés Andrés Matos, Yadelis Maldonado Martínez

“…Worldwide, less than a thousand cases have been described to date and the one that is now published constitutes the first pediatric age report in Cuba. …”
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Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems by Casanova Yaquelyn, Negro Sofia, Barcia Emilia

“…It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. To this date, there is no cure for the disease and available treatments are aimed at controlling the symptoms. …”
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High-temperature structural disorders stabilize hydrous aluminosilicates in the mantle transition zone by Baoyun Wang, Jin Liu, Yanyao Zhang, Baisheng Nie, Wei Yang, Jialong Hao, Xing Ding, Yongjun Tian

“…Abstract Hydrous aluminosilicates are important deep water-carriers in sediments subducting into the deep mantle. To date, it remains enigmatic how hydrous aluminosilicates withstand extremely high temperatures in the mantle transition zone. …”
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Maternal Cardiac Arrest: A Practical and Comprehensive Review by Farida M. Jeejeebhoy, Laurie J. Morrison

“…The aim of this paper is to increase the understanding of the important physiological differences of, and management strategies for, a maternal cardiac arrest, as well as provide institutions with the most up-to-date literature on which they can build emergency preparedness programs for a maternal arrest.…”
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Changes in hormone receptor when breast cancer metastasizes to the colon: case report and literature review by Huimeng Li, Liying Yang, Xiqiang Sun, Zhuquan Wang, Shuangwei Qin, Chengcheng Li, Gongwu Liu, Fengming Xie, Weiwei Gao

“…The metastasis of breast cancer to the colon is a rare occurrence, especially in the presence of changes in estrogen and progesterone receptors. To date, literature has only reported two cases of invasive ductal carcinoma and two cases of invasive lobular carcinoma metastasizing to the colon with concurrent changes in hormone receptors. …”
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Bowel diseases and constipation in practice of the obstetrician and gynecologist by I. V. Kuznetsova, Yu. B. Uspenskaya

“…The aim of review. To present up-to-date data on etiology, pathogenesis and treatment of constipation in women of various age groups and at combined gynecologic diseases.Summary. …”
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Biomechanics of Posterior Dynamic Stabilization Systems by D. U. Erbulut, I. Zafarparandeh, A. F. Ozer, V. K. Goel

“…Spinal rigid instrumentations have been used to fuse and stabilize spinal segments as a surgical treatment for various spinal disorders to date. This technology provides immediate stability after surgery until the natural fusion mass develops. …”
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Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura by Ana Paola Rico-Portillo, José Ignacio Cerrillos-Gutierrez, Jorge Andrade-Sierra, Alfredo Gutiérrez-Govea, Enrique Rojas-Campos, Claudia Alejandra Mendoza-Cerpa, Benjamín Gómez-Navarro

“…A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. …”
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