GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…Methods Human ovarian tissue specimens, RNA sequencing, GEPIA database and bioinformatics analyses were used to analyze the gene correlation, and to identify and validate potential downstream candidates. …”
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Genetic Biomarkers and Circulating White Blood Cells in Osteoarthritis: A Bioinformatics and Mendelian Randomization Analysis by Yimin Pan, Xiaoshun Sun, Jun Tan, Chao Deng, Changwu Wu, Georg Osterhoff, Nikolas Schopow

“…<b>Methods</b>: This study integrated transcriptome data from the GEO database with bioinformatics analyses to identify biomarkers associated with OA. …”
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Legionella pneumophila IrsA, a novel, iron-regulated exoprotein that facilitates growth in low-iron conditions and modulates biofilm formation by Alberto E. Lopez, Joshua Mayoral, Huaixin Zheng, Nicholas P. Cianciotto

“…For this study, we determined and deposited in the database a complete and fully assembled genome sequence for strain 130b.IMPORTANCEThe bacterium Legionella pneumophila is the principal cause of Legionnaires’ disease, a potentially fatal form of pneumonia that is increasing in incidence. …”
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Adaptive Hierarchical Multi-Headed Convolutional Neural Network With Modified Convolutional Block Attention for Aerial Forest Fire Detection by Md. Najmul Mowla, Davood Asadi, Shamsul Masum, Khaled Rabie

“…Building upon our prior work on the Unmanned Aerial Vehicle-based Forest Fire Database (UAVs-FFDB) and the multi-headed CNN (MHCNN), this study introduces a novel architecture, namely, the Adaptive Hierarchical Multi-Headed Convolutional Neural Network with Modified Convolutional Block Attention Module (AHMHCNN-mCBAM). …”
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The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K–AKT pathway by Xiaopei Shen, Jie Tan, Rengyun Liu, Guangwu Zhu, Lisa Rooper, Mingzhao Xing

“…Here, we investigated the oncogenic and clinical impacts of genetic alterations of RASAL1, particularly when coexisting with genetic alterations of the gene for phosphatase and tensin homolog (PTEN), in 9924 cancers of 33 types in the TCGA database. We found common concurrent genetic alterations of the two genes, which were cooperatively associated with activation of the phosphatidylinositol 3‐kinase (PI3K)–AKT pathway, with cancer progression and mortality rates being 46.36% and 31.72% with concurrent gene alterations, versus 29.80% and 16.93% with neither gene alteration (HR 1.64, 95% CI 1.46–1.84 and 1.77, 95% CI 1.53–2.05), respectively. …”
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Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort by Doron Boltin, Zohar Levi, Tsachi Tsadok Perets, Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Ram Dickman, Iris Dotan

“…Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. …”
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Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan by Lin CY, Lin CH, Lo YL, Lo CY, Huang HY, Hsieh MH, Fang YF, Li TC, Lin SM, Huang YT, Chang PJ, Lin HC

“…Chun-Yu Lin,1,2 Chiung-Hung Lin,1,2 Yu-Lun Lo,1,2 Chun-Yu Lo,1,2 Hung-Yu Huang,1,2 Meng-Heng Hsieh,1,2 Yueh-Fu Fang,1,2 Tsu-Chuan Li,1,2 Shu-Min Lin,1,2 Yu-Tung Huang,3 Po-Jui Chang,1,2 Horng-Chyuan Lin1,2,4 1Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 2College of Medicine Chang Gung University, Taoyuan, Taiwan; 3Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Respiratory Therapy, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanCorrespondence: Horng-Chyuan Lin, Department of Thoracic Medicine, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kweishan, Taoyuan, 33305, Taiwan, Tel +886-3-3281200 ext. 8470, Fax +886-3-3282474, Email lin53424@gmail.comBackground: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.Methods: We had retrospectively collected patients with asthma AEs between 2019 and 2020 and retrieved data from the Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic and emergency department visits and hospitalizations.Results: A total of 39,108 adult patients with asthma were enrolled, of whom 1502 were eligible for analysis. …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…Methods: A two-sample MR approach was employed using genome-wide association study (GWAS) data from 8293 Finnish individuals for inflammatory cytokines and data from the FinnGen database for TN. Instrumental variables (IVs) were selected based on genome-wide significance and clumping thresholds to avoid linkage disequilibrium. …”
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Novel models based on machine learning to predict the prognosis of metaplastic breast cancer by Yinghui Zhang, Wenxin An, Cong Wang, Xiaolei Liu, Qihong Zhang, Yue Zhang, Shaoqiang Cheng

“…Methods: This study utilized patient data from the SEER database (2010–2018) for data analysis. We utilized prognostic factors to develop a novel machine learning model (CatBoost) for predicting patient survival rates. …”
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Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer by Babak Jahangiri, Zahra-Soheila Soheili, Elahe Asadollahi, Mehdi Shamsara, Vahid Shariati, Alireza Zomorodipour

“…The TA-MSCs RNA-seq dataset (PRJEB27694) was analyzed todetect elevated metastasis-associated oncogenes, downloaded from the European Nucleotide Archive database. Forvalidation of the RNA-seq data analysis, the expression levels of candidate oncogenes were evaluated in TA-MSCs,TNBC cells, and tumor tissue using RT-PCR.Results: TA-MSCs enhanced migration, invasion, and EMT of TNBC cells in vitro without affecting cell proliferation orapoptosis. …”
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Penerapan Metode K-Medoids untuk Pengelompokan Mahasiswa Berpotensi Drop Out by Syamsul Bahri, Dwi Marisa Midyanti

“…Data mining analyzes data that already exists in the database to solve problems. One of the analyzes carried out is the clustering method. …”
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Sport values and sustainability? by Tess Kate Schweizer, Nicolas Margas

“…Methods Following PRISMA guidelines, we conducted a systematic review through Google Scholar, Semantic Scholar, and ERIC database using values of sport, sport values, sporting values, and athletic values keywords (n=7992). 32 studies published between 1990 and 2023 were retained. …”
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Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…Methods Firstly, the network pharmacology was used to screen the RosA targets, and LUAD-related differential expressed genes (DEGs) were acquired from the GEO database. The intersection of LUAD regulated by RosA (RDEGs) was obtained through the Venn diagram. …”
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The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis by Guilin Zhang, Guixing Xu, Yao Tang, Lingxue Zhang, Xi Chen, Xingyu Liang, Ling Zhao, Dehua Li

“…Systematic Review Registration: PROSPERO database, CRD42024506989.…”
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Identification of Adulterated Deer Blood Crystals in Traditional Chinese Medicine Based on MALDI-TOF MS Peptide Fingerprints Technique by Shen-xing WANG, Ling CAO, Qing HUANG, Cong-yu MA, Jian-bin PAN, Hao-dong ZHAO, Hai-wei SHI, Bin DI, Hong-yuan CHEN

“…Then, the mass spectrometry data were combined with UNIFI software and Uniprot database to accurately select a set of characteristic peptides that can reflect the differences between the target proteins, which was achieved by examining the presence of candidate characteristic peptides in the samples, as well as considering parameters such as the response, missed cut rate, and detection rate. …”
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Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…The MOA was explored using L1000, Drug Gene DataBase (DGDB), and Western blotting analyses.ResultsORes significantly reduces breast cancer cell viability and proliferation in a concentration-dependent manner, with IC50 values of 104.8 μM, 150.2 μM, and 143.6 μM in MDA-MB-231, BT-549, and 4T1 cells, respectively. …”
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Ten pressure points in primary care during COVID-19: findings from an international narrative review by Sally Hall Dykgraaf, Anne Parkinson, Michael Wright, William C. W. Wong, Jane Desborough, Lauren Ball, Elizabeth Sturgiss, Garang M. Dut, Katelyn Barnes, Danielle Butler, Steph Davis, Kirsty Douglas, Candan Kendir, Danielle Martin, Robert Marten, Katherine Rouleau, Shannon Barkley, Lucas de Toca, Michael Kidd

“…Methods We conducted an integrative systematic review and narrative analysis, searching PubMed/Medline, Scopus, Proquest Central and Cochrane Database of Systematic Reviews, plus reference lists of key publications. …”
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Factors associated with the dental service utilization by enrollees on the Lagos State health insurance scheme, Nigeria by Olunike Rebecca Abodunrin, Ezekiel Taiwo Adebayo, Ifeoluwa E. Adewole, Mobolaji Timothy Olagunju, Chibueze Ekeh, Ibitoye Oluwabunmi Samuel, Emmanuella Zamba, Titilola Gbaja-Biamila, Folahanmi Tomiwa Akinsolu, George Uchenna Eleje, Maha El Tantawi, Oliver Chukwujekwu Ezechi, Morẹ́nikẹ́ Oluwátóyìn Foláyan

“…Methods A cross-sectional survey was conducted from July to November 2023 recruiting from a database of 1520 enrollees aged of 18 and 72-years-old who had been on the scheme for at least three months. …”
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CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials by Dimitrios Zouraris, Angelos Mavrogiorgis, Andreas Tsoumanis, Laura Aliisa Saarimäki, Giusy del Giudice, Antonio Federico, Angela Serra, Dario Greco, Ian Rouse, Julia Subbotina, Vladimir Lobaskin, Karolina Jagiello, Krzesimir Ciura, Beata Judzinska, Alicja Mikolajczyk, Anita Sosnowska, Tomasz Puzyn, Mary Gulumian, Victor Wepener, Diego S.T. Martinez, Romana Petry, Naouale El Yamani, Elise Rundén-Pran, Sivakumar Murugadoss, Sergey Shaposhnikov, Vasileios Minadakis, Periklis Tsiros, Harry Sarimveis, Eleonora Marta Longhin, Tanima SenGupta, Ann-Karin Hardie Olsen, Viera Skakalova, Peter Hutar, Maria Dusinska, Anastasios G. Papadiamantis, L. Cristiana Gheorghe, Katie Reilly, Emilie Brun, Sami Ullah, Sebastien Cambier, Tommaso Serchi, Kaido Tämm, Candida Lorusso, Francesco Dondero, Evangelos Melagrakis, Muhammad Moazam Fraz, Georgia Melagraki, Iseult Lynch, Antreas Afantitis

“…Future efforts will concentrate on further refining these models, expanding the NanoPharos Database, and working with regulatory stakeholders thereby fostering the widespread adoption of SbD practices across the nanotechnology sector. …”
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The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China by Xiaorui Wang, Bo Zhu, Hanping Li, Jingwan Han, Xiaolin Wang, Lei Jia, Bohan Zhang, Jingyun Li, Linding Wang, Yongjian Liu, Hongling Wen, Lin Li

“…Methods With the partial pol region fragment of the HIV-1 CRF80_0107 subtype standard sequence as a reference, BLAST was used to search for highly similar sequences in the Los Alamos HIV Sequence Database, followed by preliminary subtype identification via COMET. …”
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