Enhanced recovery pathway in adult patients with spinal deformity undergoing open thoracolumbar surgery by Qingyang Huang, Lang Xiao, Shuaikang Wang, Peng Cui, Di Han, Peng Wang, Shibao Lu

“…Methods This study focused on a retrospective review of a database of previous adult spinal deformity. Adult patients with spinal deformity who underwent long-segment fusion surgery from July 2016 to July 2022 were evaluated, from July 2016 to July 2019 for the pre-ERAS patient group and from July 2019 to July 2022 for the ERAS group. …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Methods We utilized single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify key immune cell types within HGSOC tissues and to extract related markers via the Seurat package. …”
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Technological Adjuncts to Streamline Patient Recruitment, Informed Consent, and Data Management Processes in Clinical Research: Observational Study by Jodie Koh, Stacey Caron, Amber N Watters, Mahesh Vaidyanathan, David Melnick, Alyssa Santi, Kenneth Hudson, Catherine Arguelles, Priyanka Mathur, Mozziyar Etemadi

“…MethodsUsing one clinical research study as an example, we highlighted the use of technological adjuncts to automate and streamline research processes across various digital platforms, including a centralized database of electronic medical records (enterprise data warehouse [EDW]); a clinical research data management tool (REDCap [Research Electronic Data Capture]); and a locally managed, Health Insurance Portability and Accountability Act–compliant server. …”
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Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies by Ramin Assempoor, Mohammad Shahabaddin Daneshvar, Aryan Taghvaei, Alireza Sattari Abroy, Amir Azimi, John R. Nelson, Kaveh Hosseini

“…Methods PubMed, Embase, and Web of Science were systematically searched from the inception of each database to August 13, 2024. Cross-sectional studies, case-control studies, and prospective or retrospective cohort studies using multivariate analysis were included. …”
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Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults by SUN Yuxin, GUO Xiaoyuan, CHEN Shi, PAN Hui, ZHU Huijuan

“…ObjectiveTo explore the effect of resistance exercise on glycolipid metabolism in over-weight or obese people, with the aim of providing reference for the clinical development of appropriate resistance exercise programs.MethodsPubMed, Cochrane Library, EmBase, Web of Science, CNKI, Wanfang Data Knowledge Service Platform and VIP database were systematically searched to obtain the relevant literature on the effects of resistance exercise on glucose and lipid metabolism from the establishment of the library to December 31, 2023 in overweight and obese populations. …”
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Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury by Deng H, Fan Q, Huang L, Ouyang W, Zhu W

“…Gene expression data from the GEO database were analyzed, and HL-1 cardiomyocytes were used in a hypoxia/reoxygenation model to mimic reperfusion injury. …”
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Time to surgical stabilization of rib fractures: does it impact outcomes? by Joseph D Forrester, Yang Cao, Shahin Mohseni, Babak Sarani, Frank Hildebrand, Ahmad Mohammad Ismail, Maximilian Peter Forssten, Marcelo A F Ribeiro

“…Our aim was to investigate for association between time to SSRF and complications among patients with isolated rib fractures undergoing SSRF.Methods The 2016–2019 American College of Surgeons Trauma Quality Improvement Program (TQIP) database was queried to identify patient >18 years with isolated thoracic injury undergoing SSRF. …”
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Insight into influence of degradation metabolism of Firmicutes on the microstructure of anthracite coal by Yuewu Wang, Bingjun Liu, Sheng Xue, Yang Yang, Jian Chen, Jingbei Zhang, Chunshan Zheng, Tianyao Zhou

“…Metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed that the degradation of aromatic compounds by microorganisms appeared to be significantly enhanced by the addition of nitrogen sources. …”
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MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…The analysis of differentially expressed lncRNAs in the GSE201412 dataset revealed that LINC02159 was significantly upregulated following treatment with the KRASG12D inhibitor MTRX1133 Data from the GTEx database indicated that LINC02159 is highly expressed in CRC tumour tissues and is associated with better patient outcomes. …”
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Intravenous branched-chain amino acid administration for the acute treatment of hepatic encephalopathy: a systematic review and meta-analysis by Shoji Yokobori, Tomoaki Yatabe, Yutaka Kondo, Yasuhiko Ajimi, Manabu Araki, Norio Chihara, Masao Nagayama, Tetsuya Samkamoto, the Japan Resuscitation Council (JRC) Neuroresuscitation Task Force and the Guidelines Editorial Committee

“…Methods We conducted a comprehensive literature search of MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI), a Japanese database for medical literature. We included RCTs involving adult patients with acute HE who received IV-BCAA or placebo during the acute phase after admission (< 7 days). …”
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Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis by Yiming Zhao, Qifan Luo, Xiao Zhang, Yafei Qin, Jingpeng Hao, Dejun Kong, Hongda Wang, Guangming Li, Xiangying Gu, Hao Wang

“…We systematically searched PubMed, Embase, Cochrane, and Web of Science database (published up to October 3, 2020). Our main evaluation outcomes were menses improvement, endometrial thickness changes, pregnancy outcome, and side effects. …”
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Association between red cell distribution width—albumin ratio and all-cause mortality in intensive care unit patients with heart failure by Ni Li, Junling Li, Kai Wang

“…This study aimed to investigate this association.MethodsClinical data from MIMIC-Ⅳ (version 2.2) database was utilized for the analysis of ICU patients with heart failure. …”
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Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

“…Methods The Gene Expression Omnibus (GEO) database was used to obtain differential genes for CM and normal skin, and the Genome-Wide Association Studies (GWAS) analysis offered summary-level melanoma data for CM. …”
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Antibiotic Prescription Practice and Resistance Patterns of Bacterial Isolates from a Neonatal Intensive Care Unit: A Retrospective Study from Jordan by Mariam Alameri, Lobna Gharaibeh, Mervat Alsous, Aseel Yaghi, Asma’a Tanash, Saqr Sa’id, Hanan Sartawi

“…The hospital’s microbiology lab database and medical records were the sources of the retrospective data collection. …”
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Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China by Temesgen Yihunie Akalu, Archie C. A. Clements, Zuhui Xu, Liqiong Bai, Kefyalew Addis Alene

“…Sociodemographic, economic, healthcare, and environmental variables were obtained from various sources, including the WorldClim database, the Malaria Atlas Project, and the Hunan Bureau of Statistics. …”
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Large language models generating synthetic clinical datasets: a feasibility and comparative analysis with real-world perioperative data by Austin A. Barr, Joshua Quan, Eddie Guo, Emre Sezgin, Emre Sezgin

“…Recent advances in large language models (LLMs) provide an opportunity to generate synthetic data with reduced reliance on domain expertise, computational resources, and pre-training.ObjectiveThis study aims to assess the feasibility of generating realistic tabular clinical data with OpenAI’s GPT-4o using zero-shot prompting, and evaluate the fidelity of LLM-generated data by comparing its statistical properties to the Vital Signs DataBase (VitalDB), a real-world open-source perioperative dataset.MethodsIn Phase 1, GPT-4o was prompted to generate a dataset with qualitative descriptions of 13 clinical parameters. …”
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Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“…Active metabolites were sourced from the Knapsack Database. Molecular docking using Molegro Virtual Docker assessed binding energy, with more negative MolDockScores indicating stronger interactions. …”
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Using large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence by Dmitry Scherbakov, Paul M. Heider, Ramsey Wehbe, Alexander V. Alekseyenko, Leslie A. Lenert, Jihad S. Obeid

“…Methods We applied a large language model (LLM) to social history sections of clinical notes in the health records database of the Medical University of South Carolina to extract recent stressful life events and assess their impact on colorectal cancer screening adherence. …”
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Response Time Threshold for Predicting Outcomes of Patients with Out-of-Hospital Cardiac Arrest by Ling Hsuan Huang, Yu-Ni Ho, Ming-Ta Tsai, Wei-Ting Wu, Fu-Jen Cheng

“…A retrospective observational analysis was conducted using the emergency medical service (EMS) database (January 2015 to December 2019). Prehospital factors, underlying diseases, and OHCA outcomes were assessed. …”
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Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…An additional cohort of 11,864 eligible patients from the Medical Information Mart for Intensive Care Ⅳ database served as an external test set. The Boruta algorithm was used to select the most important predictor variables from 53 candidate variables. …”
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