Proton pump inhibitors versus histamine-2 receptor antagonists for stress ulcer prophylaxis during extracorporeal membrane oxygenation: a propensity score-matched analysis by Hiroki Matsui, Hideo Yasunaga, Hiroshi Tanaka, Yutaka Kondo, Hiroyuki Ohbe, Kiyohide Fushimi

“…Our aim was to compare outcomes between patients receiving PPIs and H2RAs for stress ulcer prophylaxis during ECMO.Materials and methods We performed a retrospective cohort study using the Japanese Diagnosis Procedure Combination Database, using data recorded from 1 July 2010 to 31 March 2017. …”
Get full text

Prediction of successful weaning from renal replacement therapy in critically ill patients based on machine learning by Qiqiang Liang, Xin Xu, Shuo Ding, Jin Wu, Man Huang

“…Background Predicting the successful weaning of acute kidney injury (AKI) patients from renal replacement therapy (RRT) has emerged as a research focus, and we successfully built predictive models for RRT withdrawal in patients with severe AKI by machine learning.Methods This retrospective single-center study utilized data from our general intensive care unit (ICU) Database, focusing on patients diagnosed with severe AKI who underwent RRT. …”
Get full text

Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study by Tibor Schuster, Laurent Azoulay, Julie Rouette, Emily G. McDonald, James M. Brophy

“…Objectives To describe the prescribing trends of antihypertensive drugs in primary care patients and assess the trajectory of antihypertensive drug prescriptions, from first-line to third-line, in patients with hypertension according to changes to the United Kingdom (UK) hypertension management guidelines.Design Population-based cohort study.Setting and participants We used the UK Clinical Practice Research Datalink, an electronic primary care database representative of the UK population. Between 1988 and 2018, we identified all adult patients with at least one prescription for a thiazide diuretic, angiotensin-converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta-blocker or calcium channel blocker (CCB).Primary and secondary outcome measures We estimated the period prevalence of patients with antihypertensive drug prescriptions for each calendar year over a 31-year period. …”
Get full text

Evaluation of ovarian stiffness and its biological mechanism using shear wave elastography in polycystic ovary syndrome by Yifang He, Shuangping Deng, Yanli Wang, Xiali Wang, Qingqing Huang, Jing Cheng, Dandan Wang, Guorong Lyu

“…Transcriptomic and proteomic analyses revealed that BM gene alterations were correlated with ovarian stiffness, which was further validated using PCOS patient data from the Gene Expression Omnibus database. In conclusion, SWE is a valuable technique for diagnosing PCOS by detecting increased ovarian stiffness, which may be associated with alterations in the expression of BMs, thereby mediating ovarian fibrosis.…”
Get full text

Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen by Kirsi Aaltonen, Ravi Kant, Marjut Eklund, Mirja Raunio-Saarnisto, Lars Paulin, Olli Vapalahti, Thomas Grönthal, Merja Rantala, Tarja Sironen

“…Virulence factors were assessed using the Virulence Factor Database (VFDB) concentrating on the previously confirmed streptococcal factors. …”
Get full text

GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Subsequently, the expression of hub genes was validated using additional TBI- and PD-related GEO datasets and the Comparative Toxicogenomics Database (CTD). Finally, the expression of hub genes was further validated in a mouse model of TBI induced by controlled cortical impact (CCI).Results: Shared transcriptional signatures between TBI and PD were uncovered, highlighting overlapping molecular networks and pathways. …”
Get full text

Spatiotemporal Characteristics and Influential Factors of Electronic Cigarette Web-Based Attention in Mainland China: Time Series Observational Study by Zhongmin Zhang, Hengyi Xu, Jing Pan, Fujian Song, Ting Chen

“…MethodsThe query data related to e-cigarettes for 31 provinces in mainland China were retrieved from the Baidu index database from January 1, 2015, to December 31, 2022. …”
Get full text

Correlation Between Objective Habit Metrics and Objective Medication Adherence: Retrospective Study of 15,818 Participants From Clinical Studies by Antoine Pironet, L Alison Phillips, Bernard Vrijens

“…MethodsThe Medication Event Monitoring System Adherence Knowledge Center, a database of anonymized electronic medication intake data from ambulant participants enrolled in past clinical studies, was used as the data source. …”
Get full text

Investigation of Coolant Local Hydrodynamics in the Mixed Core of the VVER Reactor by S. M. Dmitriev, A. V. Gerasimov, A. A. Dobrov, D. V. Doronkov, A. N. Pronin, A. V. Ryazanov, D. N. Solntsev, A. E. Khrobostov

“…The results of the study of the coolant cross flow between fuel assemblies interaction, i.e. between the adjacent TVSA-T and TVSA-T mod.2 fuel assemblies were adopted for practical use in the JSC of “Afrikantov OKB Mechanical Engineering” for assessing the heat engineering reliability of VVER reactor cores; also, they were included in the database for verification of computational hydrodynamics programs (CFD codes) and for detailed cell-based calculation of the reactor core.…”
Get full text

Synergistic Effects of Extra X Chromosome on Development of Systemic Lupus Erythematosus and Sjögren Disease in Klinefelter and Triple X Syndrome: A Retrospective Cohort Study by Anna‐Kay Palmer, Irene J. Tan

“…Methods This multicenter, retrospective cohort study used TriNetX, a global federated research database. Using International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes, patients with a diagnosis of SLE or SjD in the general population, as well as those with SLE and SjD in KS (karyotype 47,XXY) and triple X syndrome (karyotype 47,XXX) from January 1, 2010, to January 1, 2024, were identified. …”
Get full text

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis by Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li

“…The TB datasets were downloaded from the GEO database. Three machine learning models, namely LASSO, RF, and SVM-RFE, were used to identify the key characteristic genes related to inflammation during the progression of LTBI to ATB. …”
Get full text

Upper Quarter Injury Rates and Risk in United States High School Athletes Prior To and During the Prolonged Sport Stoppage by Garrett Bullock, Charles Thigpen, Albert Prats-Uribe, R. Gill Gilliand, Ellen Shanley

“…Injuries were reported by at least one high school athletic trainer assigned to each school into a centralized database and data collected from July 1, 2019, to June 30, 2021. …”
Get full text

Evaluating agreement between individual nutrition randomised controlled trials and cohort studies - a meta-epidemiological study by Julia Stadelmaier, Gina Bantle, Lea Gorenflo, Eva Kiesswetter, Adriani Nikolakopoulou, Lukas Schwingshackl

“…Methods MEDLINE, Epistemonikos, and the Cochrane Database of Systematic Reviews were searched from January 2010 to September 2021. …”
Get full text

Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR by Liang Cao, Wen Jun Pi, Qiang Zhang, Qing Li

“…We analyzed 16 m5C-based regulators of RNA modification in tissues with SCI and normal rats from the Gene Expression Omnibus database. We constructed a “gene signature” of m5C-based regulators of RNA modification to predict the prognosis of SCI using least absolute shrinkage and selection operator regression and random-forest strategy. …”
Get full text

Integrated Analysis and Validation of Ferroptosis-Related Genes Associated with Ischemia/Reperfusion Injury in Lung Transplantation by Li Q, Yin J, Lin Q, He J, Shi X, Nie H

“…This study aims to explore the role of ferroptosis in lung transplantation-related ischemia/reperfusion injury and to identify its potential molecular mechanisms through bioinformatics analysis.Methods: Transcriptome data from lung transplant patients were obtained from the Gene Expression Omnibus (GEO) database. Ferroptosis-related differentially expressed genes (FRGs) were identified by analyzing gene expression profiles before and after reperfusion. …”
Get full text

A descriptive analysis of a medical humanitarian aid initiative for quality perinatal management in war-torn Ukraine by Iryna Mogilevkina, Dmytro Dobryanskyy, Rhona MacDonald, Diane Watson, David Southall

“…Methods Data from 28,808 births were collected in specially developed database which contained information on maternal characteristics, course of pregnancy and childbirth, maternal and neonatal outcomes and donated drugs and equipment used. …”
Get full text

Health-Related Quality of Life Subdomains in Patients with Parkinson’s Disease: The Role of Gender by Anja Ophey, Carsten Eggers, Richard Dano, Lars Timmermann, Elke Kalbe

“…Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL in PD. 245 PD patients (age: M = 69.64, SD = 8.43; 62.9% male; H&Y: Md = 3.00; cognitive assessment with PANDA: M = 24.82, SD = 3.57) from the baseline database of the Cologne Parkinson Network were used to reevaluate the dimensionality of the PDQ-39 with a principal component analysis (PCA). …”
Get full text

Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

“…We sought to investigate the functional genomic response and altered metabolic pathways of human cancer cells to oHSV-1 infection and to elucidate the influence of these responses on the relationship between the virus and the cancer cells.MethodsTwo datasets containing gene expression profiles of tumor cells infected with oHSV-1 (G207) and non-infected cells from the Gene Expression Omnibus (GEO) database were processed and normalized using the R software. …”
Get full text

Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients by Yaxiong Liu, Honghui Li, Jinsong Li, Changlong Wei, Jinsheng Zeng, Qiuhong Tian

“…The data of hormone receptor-negative T1a and T1bN0M0 breast cancer patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. All patients were divided into two groups according to the history of adjuvant CT namely the CT group and the no CT (No CT) group. …”
Get full text

Intensive home visiting for adolescent mothers in the Family Nurse Partnership in England 2010–2019: a population-based data linkage cohort study using propensity score matching by Ruth Gilbert, Jan van der Meulen, Katie Harron, Eilis Kennedy, Sally Kendall, Francesca Cavallaro

“…Background We evaluated the effectiveness of the Family Nurse Partnership (FNP), an intensive home visiting programme aiming to improve birth outcomes, child health and development, and to promote economic self-sufficiency among teenage mothers.Methods We created a linked cohort of >130 000 mothers aged 13–19 years with live births between April 2010 and March 2019, using administrative data from health (Hospital Episode Statistics), education and children’s social care (National Pupil Database). Using propensity score matching, we compared indicators of child maltreatment, health and development outcomes, and maternal hospital utilisation and educational outcomes up to 7 years following birth for mothers who did or did not enrol in FNP.Results We found no evidence of an association between FNP and indicators of child maltreatment, except for an increased rate of unplanned admissions for maltreatment/injury-related diagnoses up to age 2 years for children born to FNP mothers (6.6% vs 5.7%, relative risk (RR) 1.15; 95% CI 1.07, 1.24). …”
Get full text