Cohort study evaluating pressure ulcer management in clinical practice in the UK following initial presentation in the community: costs and outcomes by Julian F Guest, Graham W Fuller, Peter Vowden, Kathryn Ruth Vowden

“…Objectives The aim of this study was to estimate the patterns of care and annual levels of healthcare resource use attributable to managing pressure ulcers (PUs) in clinical practice in the community by the UK’s National Health Service (NHS), and the associated costs of patient management.Methods This was a retrospective cohort analysis of the records of 209 patients identified within a randomly selected population of 6000 patients with any type of wound obtained from The Health Improvement Network (THIN) Database, who developed a PU in the community and excluded hospital-acquired PUs. …”
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Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study by Annie S Anderson, Callum G Fraser, Judith A Strachan, Robert JC Steele, Gavin RC Clark, Thomas G Godfrey

“…In addition, linkage between the Scottish Bowel Screening Database and the SCR allowed investigation of any association between screening participation and CRC incidence.Setting Scotland and the Scottish Bowel Screening Programme, in which guaiac faecal occult blood test screening was piloted from March 2000 and fully rolled by December 2009.Participants From the introduction of screening in 2000 through to 2017, 2 395 172 were invited to participate, of whom 1 487 999 participated at least once.Main outcome measures Incidence of CRC.Results In the screening age range (50–74 years), CRC incidence peaked at 156.5 cases per 100 000 in 2010 after full roll-out of screening across Scotland but fell to 123.9 per 100 000 in 2017. …”
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<i>Solanum nigrum</i> L. is a potato spindle tuber viroid reservoir by N. V. Mironenko, A. V. Khiutti, E. I. Kyrova, N. M. Lashina, O. S. Afanasenko

“…The amplification products were cloned and sequenced, and the nucleotide sequences were deposited in the GenBank database.Results. RT-PCR showed that 80–100% of plants were infected with PSTVd. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Objective To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.Design Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sources MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. …”
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Peptides of Trypsin Hydrolyzate in Bovine Colostrum by Sergei L. Tikhonov, Natalia V. Tikhonova, Khatam Kh. Tursunov, Irina G. Danilova, Vladimir A. Lazarev

“…Its peptide composition was determined on a MALDI-TOF mass spectrometer, while the protein sequences were deciphered using the Mascot database. Proteins were precipitated with ammonium sulfate, and the antimicrobial activity was measured by the disk-diffusion method against gram-positive and gram-negative bacteria and dipoloid fungi. …”
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Stereotactic body radiation therapy for hepatocellular carcinoma: Practice patterns, dose selection and factors impacting survival by Jared R. Robbins, Ryan K. Schmid, Abdulrahman Y. Hammad, Thomas Clark Gamblin, Beth A. Erickson

“…Materials/Methods Query of the National Cancer Database (NCDB) identified patients with unresectable, nonmetastatic HCC who received SBRT from 2004 to 2013. …”
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Death and dying in prehospital care: what are the experiences and issues for prehospital practitioners, families and bystanders? A scoping review by Alison Richardson, Michelle Myall, Helen Pocock, Robert Crouch, Charles Deakin, Susi Lund, Alison Rowsell, Mick Arber, Joanne Turnbull

“…Papers were analysed using thematic analysis.Data sources MEDLINE; Embase; CINAHL; Scopus; Social Sciences Citation Index (Web of Science), ProQuest Dissertations &amp; Theses A&amp;I (Proquest), Health Technology Assessment database; PsycINFO; Grey Literature Report and PapersFirst were searched from January 2000 to May 2019.Eligibility criteria for selecting studies Qualitative and mixed methods studies reporting the experiences of PHPs, families and bystanders of death and dying in prehospital settings as a result of natural causes, trauma, suicide and homicide, &gt;18 years of age, in Europe, USA, Canada, Australia and New Zealand.Results Searches identified 15 352 papers of which 51 met the inclusion criteria. …”
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Multimodal machine learning for analysing multifactorial causes of disease—The case of childhood overweight and obesity in Mexico by Rosario Silva Sepulveda, Magnus Boman, Magnus Boman

“…Main findings from this study differed from previous studies using only traditional statistical methods on the same database. Notably, the BMI of a randomised adult within the household emerged as the most important feature, rather than maternal BMI, as reported in previous literature where unwanted cultural bias went undetected.ConclusionOur general conclusion is that multimodal machine learning is a promising approach for comprehensively analysing obesogenic environments. …”
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Effects of removing reimbursement restrictions on targeted therapy accessibility for non-small cell lung cancer treatment in Taiwan: an interrupted time series study by Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang

“…Another targeted therapy, erlotinib, was initially approved as a third-line therapy in 2007, and it became a second-line therapy in 2008.Objectives This study is aimed towards an exploration of the impacts of the Taiwan NHI reimbursement policies (removing reimbursement restrictions) related to accessibility of targeted therapies.Setting We retrieved 2004–2013 claims data for all patients with lung cancer diagnoses from the NHI Research Database.Design and outcome measures Using an interrupted time series design and segmented regression, we estimated changes in the monthly prescribing rate by patient number and market shares by cost following each modification of the reimbursement policy for gefitinib and erlotinib for NSCLC treatment.Results Totally 92 220 patients with NSCLC were identified. …”
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The mental health impacts of the COVID-19 pandemic among individuals with depressive, anxiety, and stressor-related disorders: A scoping review. by Christine M Wickens, Veda Popal, Venesa Fecteau, Courtney Amoroso, Gina Stoduto, Terri Rodak, Lily Y Li, Amanda Hartford, Samantha Wells, Tara Elton-Marshall, Hayley A Hamilton, Graham W Taylor, Kristina L Kupferschmidt, Branka Agic

“…<h4>Sources of evidence</h4>Database-specific subject headings and natural language keywords were searched in Medline, Embase, APA PsycInfo, and Cumulative Index to Nursing & Allied Health Literature (CINAHL) up to March 3, 2021. …”
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COVID-19 vaccine misinformation in English-language news media: retrospective cohort study by Peter Lurie, Jordan Adams, Mark Lynas, Karen Stockert, Robyn Correll Carlyle, Amy Pisani, Sarah Davidson Evanega

“…Objectives To describe COVID-19 vaccine misinformation and track trends over time in traditional news media.Design Retrospective cohort study of a large database of online articles, July 2020–June 2021.Setting English-language articles from 100 news outlets with the greatest reach.Main outcome measures Numbers and percentages of articles containing COVID-19 vaccine misinformation over the study period. …”
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τSQWRL: A TSQL2-Like Query Language for Temporal Ontologies Generated from JSON Big Data by Zouhaier Brahmia, Fabio Grandi, Rafik Bouaziz

“…The new language has been inspired by the features of the consensual temporal query language TSQL2 (Temporal SQL2), well known in the temporal (relational) database community. The aim of the proposal is to enable and simplify the task of retrieving any desired ontology version or of specifying any (complex) temporal query on time-varying ontologies generated from time-varying big data. …”
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Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis by Guangjie Wang MD, Chenxiao Hao MD, Sun Yao MD, Yiqin Wang PHD, Zongtao Xu MD, Huiying Zhao MD, Youzhong An MD

“…Using data from the Peking University People's Hospital Investigation on Sepsis-Induced Coagulopathy database, we categorized patients into DIC and non-DIC groups based on DIC scores within 24 h of ICU admission (< 5 cutoff). …”
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Usefulness of the Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) for Predicting Poor Outcomes in Patients Undergoing Lumbar Decompression Surgery by Kazuyuki Watanabe, Koji Otani, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Junichi Handa, Shoji Yabuki, Shin-Ichi Kikuchi, Shin-Ichi Konno

“…The purpose of this study was to clarify the relationship between BS-POP scores and surgical outcomes in patients with lumbar spinal stenosis (LSS). Methods. From our database, a total of 157 patients with LSS who had undergone decompression surgery and completed a 1-year follow-up were retrospectively observed. …”
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Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive... by Jing Huang, Runtian Cheng, Xiaoshuang Liu, Li Chen, Tianyou Luo

“…Moreover, the associations between the significant neuroimaging values and the cognitive scores and gene expression values from Allen Human Brain Atlas database were evaluated using partial least squares regression and partial correlation analysis. …”
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The prognostic value of pulmonary hypertension in intensive care unit patients from Beth Israel Deaconess Medical Center (BIDMC) by Huibiao Deng, Peng Wang, Minxing Liu

“…Methods The Medical Information Mart for Intensive Care (MIMIC)-IV database was used. Patient characteristics and clinical outcomes of ICU patients with or without PH were compared. …”
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Amphetamine use as a predictor of cardiovascular and cerebrovascular mortality and morbidity: a longitudinal cohort study of criminal justice clients by Ada Åhman, Jonas Berge, Anders Håkansson

“…Data on age, sex, self-reported injection drug, tobacco use, and time in prison or custody were retrieved from the ASI database. The clients were followed in national registers up to 2014 with respect to cardiovascular and cerebrovascular morbidity and mortality. …”
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A cross-sectional study on the association between physical activity and the risk of colon cancer based on NHANES 2007–2018 by Daoyang Zou, Xi Xin, Yunxian Xu, Huangzhen Xu, Tianwen Xu

“…Data related to the study were obtained from the NHANES database for participants aged 20 and above between 2007 and 2018. …”
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Engineering of Dihydroxy Biphenyl Dioxygenase Enzyme to Improve Its Performance In Removing PCBs: A Molecular Docking Study by Susan Yazdankhah, Alireza Zakeri, Saeed Khalili, Abolfazl Jahangiri, ZahraalSadat Hashemi, Alireza Heidari

“…Materials and Methods: The amino acid sequence of the enzyme was obtained from the UniPprot database and to check similar sequences with PSI-BLAST method, similar sequences were searched from close to distant protein species. …”
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Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…Furthermore, based on bioinformatics analysis of mRNA expression data from 30 types of tumors obtained from TCGA database, malignant melanoma was identified as the most suitable indication for CTAC-PDL1 due to its specific characteristics of tumor immune. …”
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