GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2 by Junbo He, Liangzhi Wang, Mengjia Lv, Yiming Yuan

“…Methods GGCT expression in HCC and its effect on patient survival curve in HCC were evaluated utilizing the UALCAN database, along with western blot. CCK-8, EdU, and wound healing, together with transwell and western blot assays were adopted to assess the capabilities of cells to proliferate, migrate, invade, and epithelial-mesenchymal transition (EMT). …”
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Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis by Cheng Z, Wu J, Xu C, Yan X

“…IVW analysis demonstrated that frailty was associated with increased risk of COPD in both the GBMI cohort (95% CI, 1.475 to 2.158; P = 2.40× 10− 9) and the FinnGen database (1.411 to 2.434; 9.02× 10− 6). Concurrently, COPD was identified as a susceptibility factor for frailty (P < 0.05). …”
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Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis by Hongliang Zhang, Tingting Chen, Yunyan Zhang, Jiangbo Lin, Wenjun Zhao, Yangyang Shi, Huichong Lau, Yang Zhang, Minjun Yang, Cheng Xu, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen

“…Analyses including differential expressed gene (DEG) via DEGseq, weighted gene coexpression network (WGCNA), and VisANT were performed to identify crucial genes associated with AD. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was also utilized to analyze Gene Ontology (GO). …”
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Comparison of the performance of three classification criteria for Behçet's Disease in a single centre cohort from South India by Vishnu S Chandran, Suma Balan

“…Methods: In this retrospective study eligible patients were identified from a database and their already recorded characteristics were analyzed. …”
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Ensuring representative sample volume predictions in microplastic monitoring by Richard K. Cross, Sarah L. Roberts, Monika D. Jürgens, Andrew C. Johnson, Craig W. Davis, Todd Gouin

“…To examine this issue, a previously compiled database containing 1603 marine observations and 208 freshwater observations of microplastic concentrations from across the globe between 1971 and 2020 was analysed. …”
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Enhancing epidemic preparedness: a data-driven system for managing respiratory infections by Moslem Sarani, Katayoun Jahangiri, Manoochehr Karami, Mohammadreza Honarvar

“…The dashboard, developed using Power BI visualizes epidemiological trends, intervention outcomes, and resource utilization. A relational database schema ensures efficient data retrieval, facilitating comprehensive analysis. …”
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Structural and free energy landscape analysis for the discovery of antiviral compounds targeting the cap-binding domain of influenza polymerase PB2 by Amr S. Abouzied, Saad Alqarni, Kareem M. Younes, Sanad M. Alanazi, Dana M. Alrsheed, Rawabi K. Alhathal, Bader Huwaimel, Akram M. Elkashlan

“…Compounds were selected from the Diverse lib database and assessed for their binding affinity and stability in interaction with the PB2 CAP-binding domain. …”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Given vitamin A’s antioxidant properties and its therapeutic effects on inflammation, this study aims to elucidate how vitamin A influences mitochondrial metabolic reprogramming in inflammatory states, specifically in periodontitis, through genetic bioinformatics and experimental methods.MethodThe study utilized the GSE16134 dataset from the Gene Expression Omnibus (GEO) database, focusing on human periodontitis. Vitamin A-targeted genes (ATGs) were identified and analyzed using CIBERSORT to explore their role in inflammation. …”
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Identification of biomarkers associated with coronary artery disease and non-alcoholic fatty liver disease by bioinformatics analysis and machine learning by Chuan Lu, Mei Han, Qiqi Ma, Li Ying, Yue Zhang

“…We downloaded CAD and NAFLD datasets from the Gene Expression Omnibus (GEO) database and analyzed the differentially expressed genes (DEGs) by limma. …”
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Crop genes modified using CRISPR/Cas system by A. M. Korotkova, S. V. Gerasimova, V. K. Shumny, E. K. Khlestkina

“…The search for “CRISPR &amp; crop name” within article titles, abstracts and keywords in the Scopus database was carried out for 45 crops. Among a total of 206 search results, only 88 have been recognized as original articles describing editing crop genes with the CRISPR/Cas system. …”
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Taxonomic refinement of Bacillus thuringiensis by Nagham Shiekh Suliman, Reza Talaei-Hassanloui, Hamid Abachi, Sadegh Zarei, Ebrahim Osdaghi

“…By October 2023, whole genome sequences (WGS) of 885 bacterial strains were labeled as B. thuringiensis in the NCBI GenBank database. This study investigates the taxonomic authenticity of those strains using DNA similarity indexes, i.e., average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH). …”
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The Value of Immune-Related Genes Signature in Osteosarcoma Based on Weighted Gene Co-expression Network Analysis by Xin Wang, Li Gan, Ju Ye, Mengjie Tang, Wei Liu

“…Expression profiling data and clinical data for OS were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. ESTIMATE calculates immune scores and stromal scores of samples and performs the prognostic analysis. …”
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Morphologically-analyzed and syntactically-annotated Quran datasetMendeley Data by Majdi Sawalha, Faisal Al-Shargi, Sane Yagi, Abdallah T. AlShdaifat, Bassam Hammo, Mariam Belajeed, Lubna R. Al-Ogaili

“…The dataset is structured in multiple formats (tab-separated text file (tsv), SQLite3 database (.db), comma-separated file (csv), and JavaScript Object Notation (.JSON)) to cater to various research needs. …”
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Early referral to nephrological care improves long-term survival and hospitalization after dialysis initiation, independent of optimal dialysis start – a call for harmonization of... by Mathias Haarhaus, Lavinia O. Bratescu, Nicolae Pana, Emanuela M. Gemene, Eliana M. Silva, Carla Alexandra R. Santos Araujo, Fernando Macario

“…Clinical and laboratory data were retrieved from the quality database of the nephrological care providers. Patients were followed for a median (25–75%) of 36 (16–36) months. …”
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Integration of Multi-Source Landslide Disaster Data Based on Flink Framework and APSO Load Balancing Task Scheduling by Zongmin Wang, Huangtaojun Liang, Haibo Yang, Mengyu Li, Yingchun Cai

“…Utilizing Kafka as a message queue, a real-time data pipeline was constructed, with Flink facilitating data processing and read/write operations for the database. This implementation achieves efficient integration of multi-source landslide data. (3) Compared to Flink’s default task scheduling strategy, the cluster load balancing strategy based on APSO demonstrated a reduction of approximately 4.7% in average task execution time and an improvement of approximately 5.4% in average system throughput during actual tests using landslide data sets. …”
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Identification of Bacterial Lipopolysaccharide-Associated Genes and Molecular Subtypes in Autism Spectrum Disorder by He Y, He Y, Cheng B

“…This research aims to explore bacterial lipopolysaccharide (LPS)- and immune-related (BLI) molecular subgroups in ASD to enhance understanding of the disorder.Methods: We analyzed 89 control samples and 157 ASD samples from the GEO database, identifying BLI signatures using least absolute shrinkage and selection operator regression (LASSO) and logistic regression machine learning algorithms. …”
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Discovery and Characterization of Novel Esterases with Ethyl Carbamate-Hydrolyzing Activity by LIU Qingtao, ZHU Sibao, WANG Tianwen, LI Chuang, QIAN Senhe, ZHANG Wenqing, CHENG Fan, TIAN Shufang

“…In this study, four esterases (ES1, ES5, ES8 and ES9) with relatively high ethyl carbamate (EC)-hydrolyzing activity at both pH 4.5 and 7.0 were identified from the NCBI database, and their soluble expression in recombinant Escherichia coli was achieved. …”
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The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients by Mohamad Adam Bujang, Pei Xuan Kuan, Xun Ting Tiong, Fatin Ellisya Saperi, Mastura Ismail, Feisul Idzwan Mustafa, Abd Muneer Abd Hamid

“…Patients’ particulars were derived from the database between 1st January 2009 and 31st December 2009. …”
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The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007–2010 by Yaoling Cao, Zhihao Yang, Qinqing Tang

“…Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2007 to 2010, a cross-sectional study including 4,462 participants (2,386 males and 2,076 females) was performed to assess the relationship between the OBS, constipation, and diarrhea, among adult men and women in the US. …”
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Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

“…We used the National Cancer Database (NCDB) to identify adults who underwent resection for a single primary T3 or T4 colon cancer between 2006 and 2018. …”
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