Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi by Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash

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Impact of adjuvant trastuzumab therapy and its discontinuation on cardiac function and mortality in patients with early-stage breast cancer: An analysis based on the Japanese Receipt Claim Database by Keiko Miyazato, Hiroshi Ohtsu, Akihiko Shimomura, Naohiro Yonemoto, Chikako Shimizu, Kazuhiro Sase, Shinichiro Ueda

“…We aimed to investigate the association between trastuzumab discontinuation, the development of cardiac dysfunction during trastuzumab treatment, and all-cause mortality using the JMDC as the Japanese claims database. Between 2010 and 2019, 1779 women with early-stage breast cancer underwent surgery with adjuvant trastuzumab therapy (TZ). …”
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UK Biobank MRI data can power the development of generalizable brain clocks: A study of standard ML/DL methodologies and performance analysis on external databases by Marco Capó, Silvia Vitali, Georgios Athanasiou, Nicole Cusimano, Daniel García, Garth Cruickshank, Bipin Patel

“…To this end we designed a statistical framework to assess age prediction performance, the robustness of the prediction across cohort variability (database, machine type and ethnicity) and its potential as a biomarker for neurodegenerative conditions. …”
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Correction: Vertebral artery dissection in a patient with migraine treated with calcitonin gene-related peptide monoclonal antibody: a case report and FAERS database analysis by Daiki Tokuyasu, Shungo Imai, Shih-Pin Chen, Keiko Ihara, Narumi Watanabe, Yoshikane Izawa, Jin Nakahara, Satoko Hori, Tsubasa Takizawa

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Association between red blood cell distribution width-to-albumin ratio at admission and all-cause mortality in patients with acute pancreatitis based on the MIMIC-III database. by Qingsong Wu, Lianyi Liao, Qingjun Deng

“…<h4>Design</h4>This investigation was conducted as a retrospective analysis utilizing data from the Medical Information Mart for Intensive Care (MIMIC)-III database.<h4>Participants</h4>Patients with acute pancreatitis were selected from the MIMIC-III database according to predefined eligibility criteria.…”
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Age Cutoff and Yield of Prompt Esophagogastroduodenoscopy to Detect Malignancy in Vietnamese with Upper Gastrointestinal Symptoms: An Endoscopic Database Review of 472,744 Patients from 2014 to 2019 by Duc Trong Quach, Lan Thi-Ngoc Tran, Truc Le-Thanh Tran, Vy Ly-Thao Tran, Nhan Quang Le, Toru Hiyama

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Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A Retrospective Database Analysis by Ci Song, Peter Kunovszki, Amélie Beaudet

“…**Objectives:** To conduct retrospective database analyses to describe characteristics of patients with PAH initiating therapy with these agents and compare the rate and risk of healthcare facility encounters and drug persistence. …”
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PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database by Alexandre O. Gérard, Alexandre O. Gérard, Alexandre O. Gérard, Diane Merino, Diane Merino, Jonathan Benzaquen, Alexandre Destere, Delphine Borchiellini, Clément Gosset, Clément Gosset, Fanny Rocher, Marine Andreani, Charles-Hugo Marquette, Henri Montaudié, Henri Montaudié, Milou-Daniel Drici, Antoine Sicard, Antoine Sicard

“…ICI may trigger allograft rejection, but the absolute risk of AR between the different ICI classes remains to be defined.MethodsVigiBase® (WHO’s pharmacovigilance database) was queried for reports of AR involving CTLA4, PD1, or PDL1 inhibitors. …”
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Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study by Yoshihide Inayama, Ken Yamaguchi, Kayoko Mizuno, Sachiko Tanaka-Mizuno, Ayami Koike, Nozomi Higashiyama, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Junzo Hamanishi, Satomi Yoshida, Masaki Mandai, Koji Kawakami

“…MethodsThis was a retrospective cohort study using a Japanese claims database provided by DeSC Healthcare Inc, in which daily step count data, derived from smartphone pedometers, are linked to the claims data. …”
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Prognostic Value of the Red Blood Cell Distribution Width-to-Albumin Ratio in Critically Ill Older Patients with Acute Kidney Injury: A Retrospective Database Study by Lei Guo, Dezhun Chen, Bihuan Cheng, Yuqiang Gong, Benji Wang

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Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database by Yuwen Chen, Jian Xu, Fan He, An’an Huang, Jie Wang, Bingchen Liu, Qucheng Wei

“…Methods We extracted data from the Medical Information Mart for Intensive Care (MIMIC-IV) database for patients diagnosed with cerebrovascular disease and used Cox regression to assess the association between SHR and mortality. …”
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Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database by Tomohiro Iida, Aya Narimatsu, Kenji Adachi, Edward CY Wang

“…**Methods:** A hospital claims database was retrospectively reviewed for patients diagnosed with exudative AMD who were treated with anti-VEGF therapy in the outpatient setting between January 2010 and December 2012. …”
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Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids by Yunxiang Luo, Zi Ye, Yi Li, Chau Wei Wong, Shuqia Xu, Yu Deng, Zhicheng Su, Xueqing Li, Yingxiong Huang, Bing Han

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Hybrid Approach in the Analysis of Bovine Milk Protein Hydrolysates as a Source of Peptides Containing Di- and Tripeptide Bitterness Indicators by Anna Iwaniak, Piotr Minkiewicz, Monika Hrynkiewicz, Justyna Bucholska, Małgorzata Darewicz

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Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators by Lin Liu, Yan-Bo Zhao, Zhuo-Ting Cheng, Ya-Hui Li, Yang Liu

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GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules by Usha Longwani, Ashok K. Sharma, Aditya S. Malwe, Shubham K. Jaiswal, Vineet K. Sharma

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LONGPOP and IDS. Personal reflections on our collaboration With Kees Mandemakers. by Sam Jenkinson, Hideko Matsuo, Koen Matthijs

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HisCoM-mimi: software for hierarchical structural component analysis for miRNA-mRNA integration model for binary phenotypes by Yongkang Kim, Taesung Park

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COVFlow: phylodynamics analyses of viruses from selected SARS-CoV-2 genome sequences by Danesh, Gonché, Boennec, Corentin, Verdurme, Laura, Roussel, Mathilde, Trombert-Paolantoni, Sabine, Visseaux, Benoit, Haim-Boukobza, Stéphanie, Alizon, Samuel

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Decoding mutational signatures in breast cancer: Insights from a multi-cohort study by Margaux Betz, Andréa Witz, Julie Dardare, Cassandra Michel, Vincent Massard, Romain Boidot, Pauline Gilson, Jean-Louis Merlin, Alexandre Harlé

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