Real-World Assessment of Weight Change in People with HIV-1 After Initiating Integrase Strand Transfer Inhibitors or Protease Inhibitors by Yen-Wen Chen, Helene Hardy, Christopher D. Pericone, Wing Chow

“…**Methods:** This retrospective, observational cohort study included data from the Optum® deidentified Electronic Health Record (EHR) database. Adult PLWH who initiated INSTI- or PI-based regimens between March 1, 2016 and June 30, 2018 (index date was the first INSTI or PI prescription in this period) with ≥12-month baseline and follow-up periods, ≥1 weight measure during each period, and no prior antiretroviral use were included. …”
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The association between pretransplant malignancy and post-transplant survival and cancer recurrence in bilateral lung transplantation: An analysis of 23,291 recipients by Wongi Woo, MD, Hye Sung Kim, MD, Ankit Bharat, MBBS, Young Kwang Chae, MD, PhD, MBA

“…Background: Given the increasing need for lung transplants among older patients with a history of cancer, this study analyzed database registry to assess outcomes for bilateral lung transplant (BLT) recipients with pre-transplant malignancy (TM). …”
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Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

“…Objective The aim of this study was to identify the key regulatory mechanisms of cartilage injury and osteoporosis through bioinformatics methods, and to provide a new theoretical basis and molecular targets for the diagnosis and treatment of the disease.Methods Microarray data for cartilage injury (GSE129147) and osteoporosis (GSE230665) were first downloaded from the GEO database. Differential expression analysis was applied to identify genes that were significantly up-or down-regulated in the cartilage injury and osteoporosis samples. …”
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Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study by Aimin Huang, Daning Li, Zhe Fan, Jingfang Chen, Weidong Zhang, Wentao Wu

“…MBC data from the Surveillance, Epidemiology, and End Results (SEER) database (1975–2019) were analyzed using the Age-Period-Cohort (APC) model to examine trends in age, period, and birth cohort effects of MBC incidence. …”
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Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015) by Yufeng Xu, Lixia Lou, Yijie Wang, Qi Miao, Kai Jin, Menglu Chen, Juan Ye

“…We performed population-based cohort analyses using the Surveillance, Epidemiology, and End Results (SEER) database to identify patients with primary uveal melanoma from 2010 to 2015. …”
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Differential attainment at national selection for higher surgical training: a retrospective cohort study by Amanda Lee, Jennifer Cleland, John Hines, Peter Brennan, Ricky Ellis, Yasin Al-Tawarah

“…The objective of this study was to characterise the relationship between candidate sociodemographic factors and performance at National Selection for HST in the UK.Design A retrospective cohort study.Setting National Selection for HST in the UK.Participants All UK graduates in the UKMED database (https://www.ukmed.ac.uk) who underwent selection for HST from 2012 to 2019.Outcomes and measures Performance at HST Selection for each surgical specialty is measured by assessment of the candidate’s academic portfolio and multiple objective structured clinical examination style stations testing knowledge and skills. …”
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Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure by Eri Noda, Shouji Matsushima, Toru Hashimoto, Yoshitomo Tsutsui, Kayo Misumi, Nobuyuki Enzan, Keimei Yoshida, Keisuke Shinohara, Takeo Fujino, Shunsuke Katsuki, Takafumi Sakamoto, Kazuya Hosokawa, Shintaro Kinugawa, Kohtaro Abe

“…We analyzed 1,608 HF patients from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) database. Patients were classified based on the severity of admission anemia in the presence/absence of RD. …”
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A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 5 – Surgical and Injection-Based Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…A systematic review was conducted to evaluate the strength of evidence associated with various WAD therapies. Multiple databases (including Web of Science, EMBASE and PubMed) were searched to identify all studies published from January 1980 through March 2009 that evaluated the effectiveness of any well-defined treatment for acute (less than two weeks), subacute (two to 12 weeks) or chronic (more than 12 weeks) WAD. …”
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A sensitivity analysis of methodological variables associated with microbiome measurements by Samuel P. Forry, Stephanie L. Servetas, Jennifer N. Dootz, Monique E. Hunter, Jason G. Kralj, James J. Filliben, Scott A. Jackson

“…In this study, a full factorial experimental design was used to compare the effects of a select set of methodological choices (sample, operator, lot, extraction kit, variable region, and reference database) on the analysis of biologically diverse stool samples. …”
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Prediction of successful weaning from renal replacement therapy in critically ill patients based on machine learning by Qiqiang Liang, Xin Xu, Shuo Ding, Jin Wu, Man Huang

“…Background Predicting the successful weaning of acute kidney injury (AKI) patients from renal replacement therapy (RRT) has emerged as a research focus, and we successfully built predictive models for RRT withdrawal in patients with severe AKI by machine learning.Methods This retrospective single-center study utilized data from our general intensive care unit (ICU) Database, focusing on patients diagnosed with severe AKI who underwent RRT. …”
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Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study by Tibor Schuster, Laurent Azoulay, Julie Rouette, Emily G. McDonald, James M. Brophy

“…Objectives To describe the prescribing trends of antihypertensive drugs in primary care patients and assess the trajectory of antihypertensive drug prescriptions, from first-line to third-line, in patients with hypertension according to changes to the United Kingdom (UK) hypertension management guidelines.Design Population-based cohort study.Setting and participants We used the UK Clinical Practice Research Datalink, an electronic primary care database representative of the UK population. Between 1988 and 2018, we identified all adult patients with at least one prescription for a thiazide diuretic, angiotensin-converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta-blocker or calcium channel blocker (CCB).Primary and secondary outcome measures We estimated the period prevalence of patients with antihypertensive drug prescriptions for each calendar year over a 31-year period. …”
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Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury by Tianyun Gao, Zhiqiang Nong, Yuzhen Luo, Manqiu Mo, Zhaoyan Chen, Zhenhua Yang, Ling Pan

“…Objectives This study aims to develop and validate a prediction model in-hospital mortality in critically ill patients with sepsis-associated acute kidney injury (SA-AKI) based on machine learning algorithms.Methods Patients who met the criteria for inclusion were identified in the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and divided according to the validation (n = 2440) and development (n = 9756, 80%) queues. …”
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Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

“…Moreover, we constructed protein–protein interaction (PPI) networks, the STRING database, and identified the 10 high degree core nodes. …”
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Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen by Kirsi Aaltonen, Ravi Kant, Marjut Eklund, Mirja Raunio-Saarnisto, Lars Paulin, Olli Vapalahti, Thomas Grönthal, Merja Rantala, Tarja Sironen

“…Virulence factors were assessed using the Virulence Factor Database (VFDB) concentrating on the previously confirmed streptococcal factors. …”
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Healthcare utilisation by pregnant patients with asthma in South Korea: a cohort study using nationwide claims data by Deog Kyeom Kim, Chang-Hoon Lee, Ho Il Yoon, Jae-Joon Yim, Eun Jin Jang, Jimin Kim, Yun Jung Kim, Seongmi Choi, Joon-Ho Lee

“…Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea.Design Cohort study.Setting Nationwide insurance claims database.Participants A total of 1 306 281 pregnant women who delivered in South Korea in 2009–2011.Outcomes The prevalence and exacerbation rates of asthma requiring healthcare utilisation, and the prescription of antiasthmatic drugs during pregnancy.Results The prevalence of asthma requiring healthcare utilisation was 0.43% among pregnant women. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Subsequently, the expression of hub genes was validated using additional TBI- and PD-related GEO datasets and the Comparative Toxicogenomics Database (CTD). Finally, the expression of hub genes was further validated in a mouse model of TBI induced by controlled cortical impact (CCI).Results: Shared transcriptional signatures between TBI and PD were uncovered, highlighting overlapping molecular networks and pathways. …”
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Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes by Arthur Monjot, Jérémy Rousseau, Lucie Bittner, Cécile Lepère

“…Results A total of 2,165,106 proteins were clustered in connected components enabling analysis of a great number of sequences without any references in public databases. This approach coupled with the use of an in-house trophic modes database improved the number of proteins considered by 42%. …”
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Spatiotemporal Characteristics and Influential Factors of Electronic Cigarette Web-Based Attention in Mainland China: Time Series Observational Study by Zhongmin Zhang, Hengyi Xu, Jing Pan, Fujian Song, Ting Chen

“…MethodsThe query data related to e-cigarettes for 31 provinces in mainland China were retrieved from the Baidu index database from January 1, 2015, to December 31, 2022. …”
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Efficacy and Safety of Different Acupuncture Treatments for Cancer-Related Pain: A Systematic Review and Network Meta-Analysis by Tianle Xie MD, Can Liu MD, Yudi Wu MD, Xiuxiu Li MD, Qianyun Yang PhD, Jing Tan PhD

“…Methods: Between the time each database was created and June 3, 2024, eight databases were queried: PubMed, Cochrane, Embase, Web of Science, CNKI, Wanfang, VIP, and China Biomedicine. …”
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Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis by You Pu, Jin Yang, Lian Shui, Qianlong Tang, Xianqin Zhang, Guangguo Liu

“…The aim of this study was to systematically evaluate and analyze all predictive models used to predict dysphagia in patients with HNC after radiotherapy.MethodsPubMed, Cochrane Library, EMbase and Web of Science databases were searched from database establishment to August 31, 2024. …”
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