Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis by Negin Rahmani, Yahya Daneshbod, Hadi Mirfazaelian, Elnaz Vahidi, Sadegh Shirian

Get full text

Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…There were more CD8+ cytotoxic T-cells in the adjacent nonneoplastic areas than in the tumor tissue samples (p < 0.001). …”
Get full text

Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma by Chun Wai Wong, Rotem Leshem, Kieran Neil Sefton, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone

“…Moreover, this combination mitigated the terminal exhaustion of cytotoxic T cells by inducing a quiescent state, thereby preserving functionality. …”
Get full text

LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

Get full text

Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer by Fangze Wei, Xiaotian Xu, Jing Wang, Shi Wen Mei, Fu Qiang Zhao, Fei Huang, Ti Xian Xiao, Guo Jing Wang, Baojun Wei, Shengkai Huang, Wei Cui

Get full text

CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis by Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko

Subjects: Get full text

New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function by Filip Lewandowski, Paulina Niedźwiedzka-Rystwej

“…Additionally, newly identified cytotoxic T-cell subsets, such as CD8 + CD39 + and CD8 + CD28 + cells, demonstrate unique effector properties with potential therapeutic applications in cancer immunotherapy. …”
Get full text

Primary T-Cell Non-Hodgkin Lymphoma of the Vagina by J. L. Herraiz, A. Llueca, Y. Maazouzi, D. Piquer, A. Palmeiro, E. Calpe

“…The results of the immunohistological studies of the mass revealed the presence of a cytotoxic T-cell non-Hodgkin lymphoma, which is the least common subtype.…”
Get full text

Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis by Pascal Lapierre, Alain Lamarre

“…In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. …”
Get full text

Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants by Zhongjie Sun, Zhongyan Wu, Xuncheng Su

“…Methods: We genetically fused the chemokine XCL1 with the E6 and E7 proteins of HPV16 to target cDC1 and enhance the vaccine-induced cytotoxic T cell response, ultimately developing a DNA vaccine. …”
Get full text

Th17 Cell Enhances CD8 T-Cell Cytotoxicity via IL-21 Production in Emphysema Mice by Min-Chao Duan, Ying Huang, Xiao-Ning Zhong, Hai-Juan Tang

“…These data indirectly provide evidence that Th17 cells could be involved in the control of the local and system inflammatory response in emphysema by regulating CD8+ cytotoxic T-cell function.…”
Get full text

Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…CD27-CD70 is a receptor-ligand complex which enhances T helper and cytotoxic T cell activation, survival, and proliferation. …”
Get full text

Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease by Stephan R Targan, Richard L Deem, Fergus Shanahan

“…The cytotoxic T cells were contained within the Leu 7+, CD8+ T cell subset and were detected using anti-CD3-triggered lysis. …”
Get full text

Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients by Kamel Ait-Tahar, Amanda P. Anderson, Martin Barnardo, Graham P. Collins, Chris S. R. Hatton, Alison H. Banham, Karen Pulford

“…The aim of the present study was to investigate Sp17 epitope presentation via the presence of a cytotoxic T cell (CTL) and a CD4 T-helper (Th) response in DLBCL patients. …”
Get full text

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity by Shayla R. Mosley, Angie Chen, David N.W. Doell, Siwon Choi, Courtney Mowat, Felix Meier-Stephenson, Vanessa Meier-Stephenson, Kristi Baker

“…Here, we find that cyDNA from MSI CRC cells is inherently more capable of inducing STING activation and improves cytotoxic T cell activation by dendritic cells (DCs). Sequencing indicates that MSI cyDNA is enriched in microsatellites, which, upon DC uptake, induce anti-tumor immunity in a manner consistent with clinical MSI CRCs. …”
Get full text

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…Furthermore, OC cells utilize immune checkpoint pathways, including PD-1/PD-L1, to inhibit cytotoxic T cell activity. Targeting these inflammatory and immune evasion mechanisms offers promising therapeutic strategies. …”
Get full text

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…We used single-cell analysis with encoded peptide-human leukocyte antigen (HLA) tetramers to analyze HPV16+ and HPV33+ OPSCC tumors, characterizing the ex vivo cellular responses to HPV-derived antigens presented in major Class I and Class II HLA alleles.Results We identified robust cytotoxic T-cell responses to HPV16 proteins E1 and E2 that were shared across multiple patients, particularly in HLA-A*01:01 and HLA-B*08:01. …”
Get full text

Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Env-specific cellular immune responses in mouse splenocytes were evaluated using an Enzyme-linked immunosorbent assay (ELISpot) and in vivo cytotoxic T cell-killing assays. Results: The Env-specific humoral and cellular immune responses elicited by HIV-1 env mRNA and env–gag VLP mRNA vaccine were stronger than those induced by the DNA vaccine. …”
Get full text

Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening by Dan Zhao, Ravindra Deshpande, Kerui Wu, Abhishek Tyagi, Sambad Sharma, Shih-Ying Wu, Fei Xing, Stacey O'Neill, Jimmy Ruiz, Feng Lyu, Kounosuke Watabe

“…We integrated our results with multi-omics clinical data and performed both in vitro and in vivo assays to evaluate the role of the top candidate in regulating cytotoxic T cell killing. We identified TUBB3 as a potential target to overcome the resistance and enhance the efficacy of anti-PD-1 immunotherapy. …”
Get full text

Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes by Léa Campos de Oliveira, Anna Carla Goldberg, Maria Lucia Carnevale Marin, Karina Rosa Schneidwind, Amanda Farage Frade, Jorge Kalil, Irene Kasue Miura, Renata Pereira Sustovich Pugliese, Vera Lucia Baggio Danesi, Gilda Porta

“…Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. …”
Get full text