Investigation of the optimal platinum-based regimen in the postoperative adjuvant chemotherapy setting for early-stage resected non-small lung cancer: a Bayesian network meta-analy... by Li Zhang, Wen-Feng Fang, Yi Lv, Lan-Lan Pang, Jia-Di Gan, Yi-Hua Huang, Jun Liao, Wael Abdullah-Sultan Ali

“…In terms of the safety of adjuvant chemotherapy, the incidence of haematological toxicities and nausea/vomiting was not significantly higher in the ‘cisplatin_vinorelbine’ arm than in other chemotherapy group.Conclusion This study summarised the adjuvant cytotoxicity chemotherapy regimens for patients with early-stage resected NSCLC. …”
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Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy by Yu Z, Zhou Z, Zhao Y

“…Human breast cancer MDA-MB-231 was used to test the cytotoxicity. Flow cytometry and immunofluorescence imaging were used to study the PD-L1 inhibition in cell surface and exosomes. …”
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The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function by Shubhabrata Majumdar, Hilda Echelibe, Maria Bettini, Matthew L. Bettini

“…Functional differences were studied using in vitro cytotoxicity, degranulation and cytokine expression assays. …”
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Iron(III)–Quercetin Complex: In Vivo Acute Toxicity and Biodistribution of Novel MRI Agent by Innuan P, Kongkarnka S, Thongtharb A, Kantapan J, Dechsupa N

“…It has demonstrated therapeutic benefits in reducing inflammation in an intracerebral hemorrhage (ICH) mouse model and offers a safer alternative to gadolinium-based agents by avoiding cytotoxicity and genotoxicity. These properties make IronQ a promising candidate for safe and effective MRI contrast enhancement.Purpose: This study aims to further the development of IronQ as an MRI contrast agent by investigating its biodistribution, pharmacokinetics, and acute toxicity in a preclinical animal model.Methods: The relaxivity of IronQ was measured in water and whole blood phantoms. …”
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Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil by Shimaa A. Abd El Mageed, Ali A. S. Sayed, Ahmed Shaaban, Khaulood A. Hemida, Abdelsattar Abdelkhalik, Wael M. Semida, Ibrahim A. A. Mohamed, Mohammed A. H. Gyushi, Yasmine H. Abd Elmohsen, Taia A. Abd El Mageed

“…Abstract Background Globally, salinity poses a threat to crop productivity by hindering plant growth and development via osmotic stress and ionic cytotoxicity. Plant extracts have lately been employed as exogenous adjuvants to improve endogenous plant defense mechanisms when grown under various environmental stresses, such as salinity. …”
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Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate by Francesca Lazzara, Federica Conti, Grazia Maugeri, Velia D’Agata, Velia D’Agata, Ludovica Sotera, Claudio Bucolo, Claudio Bucolo

“…Two different in vitro models of corneal damage were carried out in corneal epithelial cells exposed to hydrogen peroxide (H2O2, 1 mM) or UVB (20 mJ/cm2). Cell viability, cytotoxicity, ROS production, and mRNA expression of pro-inflammatory cytokines (TNF-α and IL-1β) were assessed by MTT, LDH, 2′,7′–dichlorofluorescein diacetate (DCFDA) assays and Real-time PCR, respectively. …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. Considering the promising pharmacological potential of this compound and using spectroscopic techniques, HSA and human serum albumin nanoparticles (HSA-NP) were tested as carriers of this molecule. …”
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Evaluation of multidrug resistance in the Gram-negative microbiome of cancer patients and the adverse effects of their metabolites on albino rats and epithelial or fibroblasts cell... by Mervat Morsy Abbas Ahmed El-Gendy, Huda Ahmed Alghamdi, Khaled G. Abdel-Wahhab, Nabila S. Hassan, Aya A. M. El-Bondkly, Mohammed Abdel-Wahab, Ayman A. Farghaly, Ahmed Mohamed Ahmed El-Bondkly

“…Moreover, all metabolites showed marked cytotoxicity against human normal cell lines; human mammary epithelial (MCF10A), human lung fibroblasts (WI38) and human dermal fibroblasts (HDFs). …”
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Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning by Xinye Zhu, Kin-Fai Ho, Tzu-Ting Yang, Vincent Laiman, Jian Sun, Zhenxing Shen, Hsiao-Chi Chuang

“…In conclusion, PAHs in biomass PM2.5 contribute to cytotoxicity on A549 cells. PAHs in PM2.5 with high emission factors from biomass burning could cause significant human pulmonary deteritious health effects after inhalation.…”
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CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation by Jie Zhang, Jun Pei, Chengjun Yu, Jin Luo, Yifan Hong, Yi Hua, Guanghui Wei

“…GO and KEGG enrichment analysis showed that these genes are mainly involved in cytokine binding, antigen binding, NK cell-mediated cytotoxicity, activation of immune receptors and immune response, and activation of the inflammatory NF-κB signaling pathway. …”
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Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite by Pilavadi Thangamuniyandi, Devan Umapathy, Loganathan Nagarajan, Antony Joseph Velanganni Arockiam

“…Further, the blue-LED assisted anti-cancer studies (MTT assay) using 0.015-Au-ZnO towards human lung cancer cells (A549), breast cancer cells (SKBr3) show high anti-proliferation rate and low cytotoxicity against healthy human embryonic kidney cells (HEK-293) with an IC50 value of 65, 53 and 124 μg/mL respectively. …”
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Bacterial flora of the eyelids and conjunctiva in the development of inflammatory pathology in the anterior part of the eye by E.A. Kleshcheva, G.M. Chernakova, N.V. Melnikova, A.E. Kleshchev

“…Netilmicin's benefits over other antibiotics are highlighted, especially its low cytotoxicity to the corneal epithelium and conjunctiva. …”
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N-2-Hydroxypropyl Trimethyl Ammonium Chloride Chitosan-Aluminum Nano-Adjuvant Elicit Strong Immune Responses in Porcine Epidemic Diarrhea Inactivated Vaccine by Jin Z, Liu J, Guo S, Xu S, Gong X, Zhang C, Zhao K

“…The N-2-HACC-Al nano-adjuvant was characterised, and its safety was determined by analysing the cytotoxicity and hemolysis. PED inactivated vaccine (N-2-HACC-Al/PEDV) was prepared by electrostatic adsorption method, and mice were inoculated by intramural injection and orally to evaluate the immune enhancement effect and application potential of the N-2-HACC-Al/PEDV.Results: The hemolysis rate was 3.89 ± 0.12% and the activity of PK15 cells was 77.40 ± 1.74%, indicating that the N-2-HACC-Al/PEDV had good biosafety. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…LNFs were further characterized biologically by in-vitro assessment of their potency against <i>S. aureus</i> clinical strains (<i>N</i> = 16) using the Kirby–Bauer test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, by <i>ex-vivo</i> assessment to evaluate their cytotoxicity against primary human epidermal keratinocytes using MTT assay, and by in-vivo assessment to estimate their diabetic chronic wound-healing efficiency using NcZ10 diabetic/obese mice (<i>N</i> = 18). …”
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Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds by Alsulami KA, Bakr AA, Sirwi A, Elfaky MA, Shaik RA, Alshehri BY, Aodah AH, Al Fayez N, Alshehri AA, Almughem FA, Halwani AA, Tawfik EA

“…In contrast, FA/LDC-loaded PVP nanofibers exhibited EE% of 100% for FA and 84% for LDC; DL was measured at 85 ± 3 μg/mg for FA and 70 ± 3 μg/mg for LDC, while both drugs were completely released within 24 hours. The in vitro cytotoxicity study demonstrated a safe concentration of FA and LDC at ≤ 125 μg/mL. …”
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Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach by Luailik Madaniyah, Saidun Fiddaroini, Elok Kamilah Hayati, Moh. Farid Rahman, Akhmad Sabarudin

“…Characterization of the synthesized AgNPs was conducted using various techniques, including UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), particle size analysis (PSA), and transmission electron microscopy (TEM), confirming the successful synthesis, stability, and spherical morphology of the nanoparticles, with an average diameter of 7 nm and a zeta potential of −24.51 mV. In vitro cytotoxicity testing showed that AgNPs-Chit exhibited stronger anticancer activity against T47D cells with an IC50 value of 173 µg/mL, compared to AgNPs (IC50 244 µg/mL) and the Acalypha indica L extract (IC50 826 µg/mL). …”
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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice by Carmine Carbone, Roberto De Luca, Emanuele Puca, Antonio Agostini, Alessia Caggiano, Lorenzo Priori, Annachiara Esposito, Serena Ascrizzi, Geny Piro, Lisa Salvatore, Francesco De Sanctis, Stefano Ugel, Vincenzo Corbo, Dario Neri, Giampaolo Tortora

“…Conclusions Our results demonstrated that L19-IL2 enhances immune infiltration and cytotoxicity, remodeling the “cold” tumor microenvironment (TME) in PDAC. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…Also, pretreatment of TGM2high PDOs with sublethal doses of the spindle poisons paclitaxel or vincristine increased CD8+T cell activation and sensitized PDOs toward T cell-mediated cytotoxicity.Conclusions These findings indicate that targeting microtubular function therapeutically may enhance antitumor T cell responses by impacting activity of immunosuppressive cytokines in the PDAC microenvironment.…”
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Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle by Huiying Ren, Nuo Chen, Yanqing Liu, Meimei Wu, Meimei Wu, Meimei Wu, Jingsong Yan, Jingsong Yan, Jingsong Yan, Mingxiang Chang, Mingxiang Chang, Mingxiang Chang, Hanmin Li, Hanmin Li, Hanmin Li

“…Compared to the curcumin-loaded vesicles, the cytotoxicity and anticancer effects of the GCLTVs were significantly higher in vitro and in vivo. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…We systematically compared the preclinical in vitro and in vivo efficacy of T cells lentivirally transduced with CD33 CAR constructs (CD33CARTs) against human AML.Results We observed potent in vitro cytokine production and cytotoxicity of CD33CARTs incubated with human CD33+ AML cell lines, as well as robust in vivo antileukemia activity in cell line and childhood AML patient-derived xenograft (PDX) models. …”
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