A novel iron/zinc phosphate layered composite coating on Zn-0.5Li alloy for guided bone regeneration membrane applications by Chang Chen, Zhengqin Shi, Yanfang Deng, Xin Chu, Jun Cheng, Yixuan He, Yilong Dai

“…However, the uneven corrosion of Zn alloys and the release of excess Zn2+ during degradation result in local cytotoxicity, limiting their practical applications. …”
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Identification of cepharanthine as an effective inhibitor of African swine fever virus replication by Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang, Yingjuan Qian

“…In total, 6 effective anti-ASFV compounds with low cytotoxicity were identified. Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid, was the most potent inhibitor effect with an IC50 of 0.3223 μM. …”
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In vitro immunomodulatory effects of thymol and cinnamaldehyde in a pig intestinal epithelial cell line (IPEC-J2) by C. Shen, L.G. Christensen, P.B. Rasmussen, K.M. Kragh

“…This study evaluated the in vitro immune modulating effects of thymol and cinnamaldehyde blend (TCB) in a porcine gut epithelial cell line (IPEC-J2), with or without cellular damage caused by challenge with lipopolysaccharides. Cytotoxicity, permeability, wound-healing and bacteria adhesion assays were recorded. …”
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Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer by Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Abdellatif Bouazzaoui, Shaaban K. Osman, Issa Saad Al-Moraya, Abdulaziz M. Saleh Showail, Mansour Alsharidah, Ashraf Aboelela, Osamah Al Rugaie, Tarek M. Faris, Hesham M. Tawfeek

“…The synthesized AgNPs-PVP were stable, spherical in shape, with particle sizes of 122.33 ± 17.61 nm, a polydispersity index of 0.49 ± 0.07, and a negative surface charge of −19.23 ± 0.61 mV. In vitro cytotoxicity testing showed the AgNPs-PVP exhibited antiproliferation properties in PC3 in a dose-dependent manner. …”
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Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma by Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan

“…VPA treatment enhanced the susceptibility of glioblastoma cells to NKG2D CAR-T mediated cytotoxicity in both 2D monolayer and 3D tumor spheroid models in vitro. …”
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Modulation of iron metabolism by new chemicals interacting with the iron regulatory system by Yoshiaki Tsuji, Jun Ninomiya-Tsuji, Maurice Y.F. Shen, Benjamin R. DiFrancesco

“…V004-0872 increased production of mitochondrial reactive oxygen species (ROS) and exhibited cytotoxicity that was inhibited by N-acetyl cysteine but not the ferroptosis inhibitor ferrostatin-1. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…Our data revealed that the treatment of combination of antitumor angiogenesis agent anlotinib with chemotherapy drug 5-FU may have synergistic cytotoxicity to SCLC in vitro and in vivo. This treatment modality reduced cell proliferation and migration via Src/AKT pathway. …”
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Synthesis of Silver and Zinc Oxide Nanoparticles Using Polystichum lentum Extract for the Potential Antibacterial, Antioxidant, and Anticancer Activities by Deepak Kumar Shrestha, Akash Budha Magar, Manisha Bhusal, Rabina Baraili, Ishwor Pathak, Pusp Raj Joshi, Niranjan Parajuli, Khaga Raj Sharma

“…The nanoparticles also exhibit potent cytotoxicity with IC50 of 76.82 ± 1.67 μg/mL against cervical cancer cell lines. …”
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Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation by Wanjun Lin, Zifeng Huang, Xuening Zhang, Dayuan Zheng, Yanchao Yang, Meina Shi, Dongfang Yang, Tong Chu, Wenzhe Ma

“…Human breast cancer cell lines-derived xenograft tumor explants assay was used to evaluate the compound’s efficacy and to assess the induction of methuosis via NRF2 activation by tanshinlactone.ResultsTanshinlactone selectively inhibits the growth of ER+ and HER2+/EGFR + breast cancer cells while showing limited cytotoxicity against other cancer types and normal cells. …”
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Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor by Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein

“…Besides, it exhibited cytotoxicity against HepG2 and MCF-7 cancer cell lines, with IC50 values of 35.78 ± 0.863 μM and 57.62 μM ± 0.871, comparing sorafenib’s IC50 values of 5.95 ± 0.917 μM and 8.45 ± 0.912 μM. …”
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Potential of Co(II) and Cd(II) chelates of N′-(3-fluorobenzoyl)benzo[d]thiazole-2-carbohydrazide: Structural aspects, binding interactions, biological and molecular docking studies... by K. Srilaxmi, B. Sireesha

“…Anti-microbial studies carried out by pour plate method showed high activity for Cd(II)-MFBBTCH complex. Cytotoxicity of the compounds was performed for Hela and MCF cell lines by MTT assay. …”
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Antiviral and anti-inflammatory activities of favipiravir and quinine sulfate against dengue virus serotype 1 in vitro by Regita Aulia Rosalina, Beti Ernawati Dewi, Fithriyah Fithriyah

“…The FVP and QS antiviral activities were analyzed through half-maximal inhibitory concentration (IC50) and half-maximal cytotoxicity concentration (CC50) values against DENV serotype-1 on Vero cells. …”
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Agro-morphological characterization and assessment of metabolic profiling and anticancer activities in various tribulus (Tribulus terrestris L.) populations by Yasamin Dabaghkar, Ghasem Eghlima, Hossein Behboudi, Mohammadtaghi Ebrahimi, Mansour Ghorbanpour

“…IC50 calculated for the T. terrestris extracts in the 24-h treatment was from 15.02 to 27.11 µg/ml, implying that all samples had considerable cytotoxicity activity against the PC3 cells. The diversity observed among the T. terrestris populations in the studied traits shows its high potential for selecting and using the best populations in domestication, breeding, and cultivation projects.…”
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Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting by Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian

“…We performed cell experimental, included cytotoxicity assay, apoptosis analysis, proliferation assay, and migration and invasion assays. …”
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Tetrahydrobiopterin as a rheostat of cell resistance to oxidant injury by R. Steven Traeger, James Woodcock, Sidhartha Tan, Zhongjie Shi, Jeannette Vasquez-Vivar

“…Moreover, we conclude that BH4/BH2 levels are not a determinant of RSL3 cytotoxicity.…”
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Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…The concordance between hotspot mutations in tumor tissue and blood CTCs was analyzed.ResultsThe CTC sorting system exhibited good dispersion, stability, and low cytotoxicity, with a specificity of 90.54% and a sensitivity of 89.07%. …”
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Development and Characterization of Chitosan Nanoparticles Loaded with Amoxicillin as Advanced Drug Delivery Systems against Streptococcus Mutans by Abdullah J Jasem, Maha A Mahmood

“…Chitosan nanoparticles and their loaded antibiotics were discovered by scanning Electron Microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). In addition, the cytotoxicity of both the nanocomposite and amoxicillin loaded on nano-chitosan were compared to that of amoxicillin alone. …”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Multiple upregulated pathways, including leukocyte trans-endothelial migration and natural killer (NK) cell-mediated cytotoxicity, were identified. Network analysis showed that proteins were involved in 4 pathways in UC-I and 3 pathways in UC-N tissues, and participated in protein-protein interactions. …”
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Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia by Juan Li, Chunmei Ye, Hui Li, Jun Li

“…In vitro, CX-4945 enhanced the cytotoxicity of venetoclax, with the combination showing significant synergistic effects and increased apoptosis in T-ALL cell lines. …”
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An Innovative Drug Delivery System Loaded with a Modified Combination of Triple Antibiotics for Use in Endodontic Applications by Ardavan Parhizkar, Hanieh Nojehdehian, Fahimeh Tabatabaei, Saeed Asgary

“…The cell viability test (MTT) was conducted for cytotoxicity against human gingival fibroblasts. SEM micrographs of PPCMs showed spherical-like ceramic microparticles with smooth surfaces. …”
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