Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer by Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-Kong Chen, Hui-Min David Wang, Hurng-Wern Huang, Bin Huang

“…We investigated whether a splice variant of CYP26B1 is associated with the occurrence of ROS related oral and pharyngeal cancer. Cytotoxicity assays were used to measure the effects of arecoline on cell viability in a dose-dependent manner. …”
Get full text

Marine actinobacteria metabolites: unlocking new treatments for acne vulgaris by María Clara De La Hoz-Romo, María Clara De La Hoz-Romo, Luis Díaz, Luis Díaz, Javier Gómez-León, Marynes Quintero, Luisa Villamil

“…Marine-derived actinobacteria isolated from sponge Cliona varians and soft coral Eunicea fusca were screened for antibacterial activity against acne-related bacteria, specifically Staphylococcus epidermidis ATCC 14990, methicillin-resistant Staphylococcus aureus ATCC BAA44, and Cutibacterium acnes ATCC 6919. Cytotoxicity assays were performed on human dermal fibroblast (HDFa) and keratinocyte (HaCaT) cell lines to assess the safety profile of the extracts. …”
Get full text

Synthesis and Characterization of Silver and Gold Nanoparticles Using Aqueous Extract of Seaweed, Turbinaria conoides, and Their Antimicrofouling Activity by Sri Ramkumar Vijayan, Prakash Santhiyagu, Muthukkumarasamy Singamuthu, Natarajan Kumari Ahila, Ravindran Jayaraman, Kannapiran Ethiraj

“…The CLSM images clearly showed the weak adherence and disintegrating biofilm formation of marine biofilm bacterial strains treated with Ag NPs. The Artemia cytotoxicity assay recorded the LC50 value of 88.914±5.04 µL mL−1. …”
Get full text

Protective activity of propofol, Diprivan® and intralipid against active oxygen species by M. Mathy-Hartert, G. Deby-Dupont, P. Hans, C. Deby, M. Lamy

“…We also studied the protective effects of Diprivan® on endothelial cells submitted to an oxidant stress induced by H2O2/MPO system: cytotoxicity was assessed by the release of preincorporated 51Cr. …”
Get full text

Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…This mechanism, in turn, provided protection to NPC cells against T cell-mediated cytotoxicity. The underlying molecular processes revealed that the high and stable expression of SLC7A11 hindered the nuclear entry of GR, thereby suppressing TAP1 transcription and the presentation of MHC-I molecules. …”
Get full text

Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells by Xixi Hou, Xixi Hou, Longfei Mao, Huibin Zhang, Lan Wang, Baoyu He, Jingjing Guo, Jianji Wang

“…Screening for anti-inflammatory activity in microglial cells revealed that compounds e2, e16, and e20 exhibited the most promising effects without significant cytotoxicity. These compounds effectively reduced LPS-induced NO production and significantly decreased the transcription levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. …”
Get full text

Uptake of CCR7 by KIR2DS4+ NK Cells Is Induced upon Recognition of Certain HLA-C Alleles by Silvia Pesce, Simona Carlomagno, Alessandro Moretta, Simona Sivori, Emanuela Marcenaro

“…The recognition of HLA-Cw4 was confirmed by experiments of cytotoxicity against HLA-C-transfected cells. We also show that, different from resting NK cells, the acquisition of CCR7 in response to IL-18 cannot occur in IL2-activated NK cells because of a marked downregulation in their IL-18Rα expression. …”
Get full text

Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta by Amira M. Gamal-Eldeen, Hassan Amer ‎, Cinderella A. ‎ Fahmy, Haytham ‎ Dahlawi, Basem H ‎ Elesawy, Nahla L. ‎ Faizo, Bassem M. ‎ Raafat

“…Furthermore, SCE showed a potent cytotoxicity against human breast MCF-7 carcinoma cells (IC 50 27.73 µg/mL), whereas SCE treatment inhibited the activity of histone deacetylase (HDAC IC 50 37.70 µg/mL) and disturbed the pattern of cell cycle phases. …”
Get full text

Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…We detail the generation of the ADC and BsAb formats that dramatically augmented antibody-mediated precision cytotoxicity. Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
Get full text

Anti-lipid-oxidation effects and edible safety evaluation of the oil extracted by a supercritical CO2 process from coix seed fermented by Monascus purpureus by Haiying Zeng, Anran Zhu, Shengling He, Mingjun Wu, Muhammad Mazhar, Anyan Wen, Na Liu, Likang Qin, Song Miao

“…In addition, the FCS-O has been confirmed to be a very safe edible oil, with no acute toxicity (LD50 > 10 g/kg bw, considered actually non-toxic) and no induced mutagenicity, cytotoxicity or genotoxicity. These results serve as a good safety reference for future application of the oil from fermented coix seed. …”
Get full text

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier by Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman

“…Methods To determine substrates of the transporters, we stably expressed each in HEK-293 cells and performed cytotoxicity and fluorescent efflux assays with known ABCG2 substrates. …”
Get full text

The effect of cannabis-derived terpenes on alveolar macrophage function by Patrick M. Greiss, Patrick M. Greiss, Patrick M. Greiss, Jacquelyn D. Rich, Jacquelyn D. Rich, Jacquelyn D. Rich, Geoffrey A. McKay, Dao Nguyen, Dao Nguyen, Dao Nguyen, Dao Nguyen, Mark G. Lefsrud, David H. Eidelman, David H. Eidelman, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole

“…Addition of ∆9-THC to terpenes did not potentiate cytotoxicity nor phagocytosis. These results suggest that terpenes from cannabis have minimal impact on the function of alveolar macrophages.…”
Get full text

Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H2O2 LDL induced Human Peripheral Blood Mononuclear Cells (PBMC) by Jamuna S., Sakeena Sadullah M.S., Ashokkumar R., Gokul Shanmuganathan, Senguttuvan Sivan Mozhi, Niranjali Devaraj S.

“…This study has been designed to explore the protective effect of C. citratus (lemon grass) against modified LDL (OxLDL and H2O2 LDL) induced cytotoxicity in Peripheral Blood Mononuclear Cells (PBMC). …”
Get full text

Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer by Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu

“…M2d is characterized by elevated secretion of IL-10 and VEGF-A, which diminish CD8+T cells cytotoxicity and promote tumor neoangiogenesis simultaneously. …”
Get full text

Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp. gigantea Extracts and Antiadipogenesis of Harves... by Seung Hwan Hwang, Ju Hee Kim, Zhiqiang Wang, Jae-Yong Lee, Soon Sung Lim

“…Extract from SV collected in April from the Ulleung Island produced over 106.89% inhibition of adipogenesis without cytotoxicity at 50 μg/ml. This extract had a high amount of PC and K-O-R. …”
Get full text

The therapeutic potential of vitamins A, C, and D in pancreatic cancer by Alban Piotrowsky, Markus Burkard, Hendrik Schmieder, Sascha Venturelli, Olga Renner, Luigi Marongiu

“…For all three vitamins and their derivatives, tumor cell-specific cytotoxicity and growth inhibition against PDAC cells has been demonstrated in vitro and in preclinical animal models. …”
Get full text

2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity by Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior

“…<b>Methods</b>: Dozens of 2-AT and 2-aminoselenophen (2-AS) derivatives were sequentially synthesized through applications of the Gewald reaction and were then evaluated in vitro for their activities against <i>L. amazonensis</i> and for cytotoxicity against macrophages. <b>Results</b>: Several series of compounds were synthesized, and it was possible to identify some substitution patterns favorable to the activity generating compounds with IC₅₀ values below 10 µM, such as the non-essentiality of the presence of a carbonitrile group at C-3; the importance of the presence and size of cycloalkyl/piperidinyl chains at C-4 and C-5 in modulating the activity; and the increase in activity without affecting the safety of the S/Se bioisosteric substitution. …”
Get full text

A Novel Therapeutic Calcium Peroxide Loaded Injectable Bio-adhesive Hydrogel Against Periodontitis by Shaojie Dong, Yukun Mei, Yuwei Zhang, Wenqing Bu, Yifei Zhang, Changjie Sun, Rui Zou, Lin Niu

“…Materials and Methods: Gelatin-oxidized dextran hydrogel loaded with calcium peroxide and penicillin (CP-P hydrogel) was synthesized and characterized using Universal mechanical testing machine, Fourier transform infrared spectroscopy, swelling test, and dissolved oxygen meter. Furthermore, the cytotoxicity, osteogenic ability, antibacterial behavior, and alveolar bone regenerating capability of CP-P hydrogel were conducted both in vitro and in vivo. …”
Get full text

Synthesis and Spectroscopic and Biological Activities of Zn(II) Porphyrin with Oxygen Donors by Gauri Devi Bajju, Sujata Kundan, Madhulika Bhagat, Deepmala Gupta, Ashu Kapahi, Geeta Devi

“…The respective complexes of X-ZnII-t(p-CH3) PP were found to possess higher antifungal activity (up to 90%) and higher in vitro cytotoxicity against human cancer cells lines.…”
Get full text

Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…Abstract The T7 phage RNA polymerase (RNAP) is a widely used expression platform, but its implementation in non-model microbial hosts poses significant challenges due to cytotoxicity. We constructed an optimized phage phi15-based expression system as alternative to the T7 platform for a wide range of applications in Pseudomonas putida. …”
Get full text