Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands by Virtudes Moreno, Julia Lorenzo, Francesc X. Aviles, M. Helena Garcia, João P. Ribeiro, Tânia S. Morais, Pedro Florindo, M. Paula Robalo

“…Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).…”
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Overview of Cell Death Mechanisms Induced by Rose Bengal Acetate-Photodynamic Therapy by Elisa Panzarini, Valentina Inguscio, Luciana Dini

“…Their interaction triggers photochemical reactions leading to Reactive Oxygen Species (ROS) generation, that mediate cytotoxicity and cell death. In the present paper, the most important findings about the synthetic dye Rose Bengal Acetate (RBAc), an emerging photosensitizer for its efficient induction of cell death, will be reported with the aim to integrate RBAc phototoxicity to novel therapeutic PDT strategies against tumour cells. …”
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XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity by Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran

“…In co-culture system with CEA-negative CT26 cells, no differences in cytotoxicity were observed between 7XCL1-CAR and reg-CAR T cells. …”
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Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis by Iman A. Alajeyan, Jawaher Alsughayyir, Mohammad A. Alfhili

“…Importantly, L-NAME, staurosporin, D4476, urea, sucrose, and polyethylene glycol 8000 (PEG) significantly ameliorated ZTN cytotoxicity. Conclusion: ZTN stimulates PS exposure, intracellular Ca 2+ elevation, oxidative stress, and cell shrinkage. …”
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Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles) by Reza Didarian, Ibrahim Vargel

“…The antibody‐nanoparticle binding rate and cytotoxicity tests were followed by in vitro and in vivo experiments. …”
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Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green by Alicia Fernandez-Fernandez, Romila Manchanda, Tingjun Lei, Denny A. Carvajal, Yuan Tang, Syed Zahid Raza Kazmi, Anthony J. McGoron

“…However, there was no significant difference in hyperthermia cytotoxicity, with both dyes causing significant cell growth inhibition at concentrations ≥ 5 μM. …”
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St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo. by Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

“…Meanwhile, the cytoprotective role of lysosomal activation under docetaxel treatment was interrupted by St-N, leading to significant synergistic cytotoxicity of docetaxel and St-N. In docetaxel-resistant PCa homograft mice, St-N significantly inhibited the growth of RM-1/Doc homografts and enhanced the anticancer effects of docetaxel, but did not show significant toxicity. …”
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The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants by Dala N. Daraghmeh, Rafik Karaman

“…When pro-oxidant activity exceeds antioxidative capacity, oxidative stress occurs, leading to cytotoxicity. This type of stress has been linked to various pathologies, including hemolytic anemia. …”
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Ganoderma lucidum Polysaccharide (GLP) Inhibited the Progression of Oral Squamous Cell Carcinoma via the miR-188/BCL9/β-Catenin Pathway by Zhigang Zeng, Kaiyan Xiao

“…GLP had significant cytotoxicity to HSC-3 cells and was capable of inhibiting the proliferation and migration of HSC-3 cells. …”
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Combined Application of Bevacizumab and Mitomycin C or Bevacizumab and 5-Fluorouracil in Experimental Glaucoma Filtration Surgery by Lei Zuo, Jianhong Zhang, Xun Xu

“…Combined BVZ and 5-Fu and combined BVZ and MMC inhibited cell cycle, induced apoptosis, and inhibited human umbilical vein endothelial cell migration. Also, the cytotoxicity of combined BVZ and 5-Fu was lower. In animal experiments, the observation of filtering bleb survival, hematoxylin and eosin and Masson staining of filtering bleb scars, and mRNA expression levels of fibrosis markers in filtering blebs showed that combined BVZ and 5-Fu had a better antiscarring effect compared with single drugs; however, the antiscarring effect of combined BVZ and MMC was not significantly different from MMC. …”
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Exposure of cerebellar granule cells to nanosilver: Oxidative stress parameters and the protective effect of exogenous glutathione by Lidia Struzynska, Beata Toczylowska, Beata Dabrowska-Bouta, Elzbieta Zieminska

“…As oxidative stress (OS) is known to be one of the major mechanisms of AgNP-induced toxicity, in the present study, we have evaluated OS-related changes in cytotoxicity parameters in AgNP-treated cerebellar granule cells (CGCs), as well as the effectiveness of antioxidant defence systems, such as glutathione (GSH), superoxide dismutases (SOD1 and SOD2) and catalase. …”
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Advancements in Nanorobots: Innovating Bladder Cancer Treatments, Diagnosis and Patient Outcomes by Zehra Hussain, Alyssa Di Fonzo, Hermela Merhawi, Mary Gallant, Robert Girlan, Muhammad Hasibul Hasan

“…Chemically-driven micro/nanorobots (MNRs) are primarily categorized by the biocompatibility of the materials used and the cytotoxicity of their waste products. Common materials are considered, focusing on size, shape, surface charge, and surface area. …”
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Functionalized Selenium Nanoparticles Enhance Anticancer Efficacy of Doxorubicin for Hepatocellular Carcinoma Therapy by Min Guo, Ying Tang, Liang Hua, Wanling Li, Guifang Gong, Yali Zhu, Bing Zhu, Yu Xia

“…Chemotherapy is one of the most commonly used strategies for HCC patients, while the clinical application is hampered by its cytotoxicity. To address this dilemma, tumor-targeted nanotechnology has been proposed to balance the toxicity and efficacy of chemotherapy. …”
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Advancements in Nanorobots: Innovating Bladder Cancer Treatments, Diagnosis and Patient Outcomes by Zehra Hussain, Alyssa Di Fonzo, Hermela Merhawi, Mary Gallant, Robert Girlan, Muhammad Hasibul Hasan

“…Chemically-driven micro/nanorobots (MNRs) are primarily categorized by the biocompatibility of the materials used and the cytotoxicity of their waste products. Common materials are considered, focusing on size, shape, surface charge, and surface area. …”
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An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. by Jair L Siqueira-Neto, Seunghyun Moon, Jiyeon Jang, Gyongseon Yang, Changbok Lee, Hong Kee Moon, Eric Chatelain, Auguste Genovesio, Jonathan Cechetto, Lucio H Freitas-Junior

“…The automated analysis generated parameters used to quantify compound activity, including infection ratio as well as the number of intracellular amastigote parasites and yielded cytotoxicity information based on the number of host cells. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. …”
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Autonomous Defense Based on Biogenic Nanoparticle Formation in Daunomycin-Producing <i>Streptomyces</i> by Karel Beneš, Vladislav Čurn, Baveesh Pudhuvai, Jaroslav Motis, Zuzana Michalcová, Andrea Bohatá, Jana Lencová, Jan Bárta, Michael Rost, Andreas Vilcinskas, Vladimír Maťha

“…The characterization of the nanoparticles confirmed the incorporation of iron and daunomycin, indicating that this approach has the potential to mitigate cytotoxicity while improving yields. The presence of proteins associated with iron homeostasis and oxidative stress responses revealed the ability of the production strain to adapt to high iron concentrations. …”
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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Cancer cells maintain moderate levels of ROS to promote tumorigenesis, metastasis, and drug resistance; indeed, once the cytotoxicity threshold is exceeded, ROS trigger oxidative damage, ultimately leading to cell death. …”
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Investigating the effect of femtosecond laser pulses on noscapine and curcumin cellular uptake and improving drug delivery in gastric cancer cells by Nastaran Kahrarian, Hossein Behboudi, Atoosa Sadat Arabanian, Abolfazl Abedi, Reza Massudi

“…Curcumin and noscapine, two plant-derived anticancer compounds, exhibit selective cytotoxicity towards cancer cells. However, their bioavailability is poor both in vitro and in vivo. …”
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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy by Sunil Kumar, Monu Kumar Shukla, Abhishek Kumar Sharma, Gururaj K. Jayaprakash, Rajiv K. Tonk, Dinesh K. Chellappan, Sachin Kumar Singh, Kamal Dua, Faheem Ahmed, Sanjib Bhattacharyya, Deepak Kumar

“…Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. …”
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