Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…These cells had the potential to recognize subdominant EBV latency antigens as measured by cytotoxicity and IFN-γ secretion. The nude mice also exhibited significant resistance to the HLA-A2 and LMP2-positive CNE tumor cell challenge after being infused with lentiviral transduced CTLs. …”
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Case Report: Successful treatment of metastatic retinoblastoma with CNS involvement with anti-GD2 immunotherapy, intrathecal topotecan and reduced systemic chemotherapy by Cristina Larrosa, Margarida Simao-Rafael, Noelia Salvador, Juan Pablo Muñoz, Cinzia Lavarino, Guillermo Chantada, Jaume Mora, Jaume Mora

“…While additional studies are needed, the results suggest anti-GD2 mAbs and CNS-directed chemotherapy may improve long-term outcomes and reduce cytotoxicity for high-risk patients with RB.…”
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One-Step Formation of Chondrocytes through Direct Reprogramming via Polysaccharide-Based Gene Delivery by Qingtong Yu, Yan Wang, Xia Cao, Wenwen Deng, Michael Adu Frimpong, Jiangnan Yu, Ximing Xu

“…The pSox9/pmPPY nanoparticles (1:50) showed lower cytotoxicity as well as greater gene transfection efficiency than Lipofectamine 2000 and polyetherimide (PEI) (p<0.05). …”
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Chemical Synthesis, Characterization, and Biocompatibility Study of Hydroxyapatite/Chitosan Phosphate Nanocomposite for Bone Tissue Engineering Applications by Nabakumar Pramanik, Debasish Mishra, Indranil Banerjee, Tapas Kumar Maiti, Parag Bhargava, Panchanan Pramanik

“…The mechanical properties of the composite are found to be improved significantly with increase in nanoparticle contents. Cytotoxicity test using murine L929 fibroblast confirms that the nanocomposite is cytocompatible. …”
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Biocompatibility and Angiogenic Effect of Chitosan/Graphene Oxide Hydrogel Scaffolds on EPCs by Lifang Zhang, Xinping Li, Congying Shi, Gaoying Ran, Yuting Peng, Shuguang Zeng, Yan He

“…%GO showed no considerable cytotoxicity, could promote the proliferation of EPCs and tube formation, and upregulated the expressions of CD34, VEGF, MMP9, and SDF-1 in EPCs compared to the case of the scaffold with 1.0 wt.…”
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Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium Coccineum L. (Maltese Mushroom) by Zucca Paolo, Argiolas Antonio, Nieddu Mariella, Pintus Manuela, Rosa Antonella, Sanna Fabrizio, Steri Daniela, Rescigno Antonio

“…., its antimicrobial, antioxidant, and anti-tyrosinase activities; its cytotoxicity against mouse melanoma B16F10 cells; and its pro-erectile activity in adult male rats. …”
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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts by Ajith Vengellur, Elizabeth Grier, John J. LaPres

“…Overall, the results suggest that basal levels of HIF1α play a protective role against cadmium-induced cytotoxicity in mouse embryonic fibroblasts by maintaining metallothionein and antioxidant activity levels.…”
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Characterization of a pleomorphic rhabdomyosarcoma cell line by Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

“…Chemosensitivity of the PRMS cell lines was checked using cytotoxicity assays and oncogene-related and phosphoproteins by Western blot arrays. …”
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Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities by Hui Yang, Cui Wang, Qingjiang Wang, Feng Han

“…The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. …”
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Antimicrobial and Antibiofilm Activities of 4,5-Dihydro-1H-pyrazole-1-carboximidamide Hydrochloride against Salmonella spp. by Andressa C. Damim, Danilo Y. de Albuquerque, Fabiana G. S. Dantas, Fernanda Galvão, Melyssa Negri, Lucas Pizzuti, Gleison A. Casagrande, Sumbal Saba, Jamal Rafique, Kelly M. P. de Oliveira

“…In the present study, the antimicrobial and antibiofilm activities of two 4,5-dihydro-1H-pyrazole-1-carboximidamide hydrochloride, (trifluoromethyl) phenyl-substituted (compound 1) and bromophenyl-substituted (compound 2), were evaluated against four Salmonella spp. serotypes through broth microdilution and biofilm-forming activity. Further, the cytotoxicity of the compounds was evaluated by cell viability assays using cultures of HeLa and Vero cell lines, and the mutagenic potential was assessed by the Ames test. …”
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Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application by Wallace Cordeiro de Morais, Gustavo Henrique Oliveira Costa, Vinícius Leal Pitcella, João Victor Vanolli Protti, Carolina Paula de Souza Moreira, José Eduardo Gonçalves, Susana Johann, Renata Barbosa de Oliveira

“…The compound demonstrated a broad antifungal spectrum, particularly effective against <i>Cryptococcus neoformans</i> and <i>Candida auris</i>, with minimal irritant potential and low cytotoxicity. RW3 showed favorable solubility and high intestinal permeability, indicating potential for oral administration. …”
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Effect of MMT-HNT Hybrid Nanoclay on Properties of UHMWPE Composite by Rania Hasan, Sarang Pande, Pravin Bhalerao, Sachin Salunkhe, Robert Cep, Emad Abouel Nasr

“…Based on the MTT assay, all nanocomposites exhibited good biocompatibility, evident by favorable cell growth with no signs of cytotoxicity after up to 96 h of incubation in media with different amounts of material in solution.…”
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Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy.…”
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Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration by Gloria Huerta-Ángeles, Edgar Mixcoha

“…An adequate physico-chemical characterization and identification of selected physico-chemical properties of the prepared material are mandatory. Moreover, cytotoxicity and evaluation of biological effects in vitro using standardized protocols are required as preclinical. …”
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Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…Additionally, the contact-dependent or -independent cytotoxicity, along with the phagocytosis, was impaired in the TvPI4P5K- or TvArf220-deficient parasites, as well as in those treated with BAPTA or Latrunculin B. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…The in vitro cellular uptake was observed via fluorescence microscope and flow cytometry. In vitro cytotoxicity was evaluated using the CCK-8 assay, flow cytometry, and live/dead cell staining. …”
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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…We have adapted this approach to a coronally sliced whole brain organotypic culture and demonstrate distinct profiles of cytotoxicity and neuronal loss upon exposure to four mouse-adapted scrapie strains. …”
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Green Synthesis and Characterization of Biocompatible Gold Nanoparticles Using Solanum indicum Fruits by Punuri Jayasekhar Babu, Pragya Sharma, Sibyala Saranya, Ranjan Tamuli, Utpal Bora

“…EDX showed the presence of the elements on the surface of the AuNPs. The cytotoxicity of the synthesized AuNPs were tested on two different human cancer cell lines, HeLa and MCF‐7 and were found to be nontoxic, thus providing an opportunity to be used in biomedical applications.…”
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Cobalt Cardiomyopathy Secondary to Hip Arthroplasty: An Increasingly Prevalent Problem by Russel Tilney, Melanie Roberta Burg, Mark Adrian Sammut

“…Cobalt exists as a bivalent and trivalent molecule in circulation and produces a cytotoxicity profile similar to nanoparticles, causing neurological, thyroid, and cardiological pathology. …”
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Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…Despite convincing data presented, its pertinency to human studies has been met with challenges due to non-specific cytotoxicity and haemolytic capabilities. Optimisation techniques for melittin have been developed including the use of gene therapy, co-delivery and nanoparticles. …”
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