PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…These hydrogels exhibited low cytotoxicity at minimal concentrations while maintaining excellent moisture retention and antibacterial properties. …”
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Effect of cisplatin/gold chitosan nanocomposite on oral squamous cell carcinoma and oral epithelial cells by Basma Abdelrahman Ahmed, Rania Osama M. Mohsen, Marwa Sharaky, Marwa A. Ramadan, Amna H. Faid, Mai Hafez Mohamed

“…Green synthesis of AuNps from eco-friendly agents like chitosan improves the AuNps’ biocompatibility and cytotoxicity. Thus, we synthesized a novel agent of cisplatin coupled to gold chitosan nanoparticles (Cis/AuCh nanocomposite) and examined its effect in addition to the effect of chitosan-reduced gold nanoparticles (AuCh Nps) on (HNO97) OSCC cell line and normal oral epithelial cells (OEC). …”
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A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy by Shang J, Chen Y, Wang F, Yang J, Li Y, Yang L, Liu X, Zhong Z, Yue C, Zhou M

“…Cellular studies using B16F10 cells assessed cytotoxicity, cellular uptake, migration inhibition, and colony formation suppression. …”
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3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…Intrinsic properties of the scaffolds revealed no cytotoxicity while enhancing bioactivity and promoting in vitro mineralization when cultured with mesenchymal stem cells in all analyzed groups. …”
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Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model by Yuanyuan Zhang, Kewei Tian, Hong Jiang, Beibei Wang, Shu Han

“…Moreover, NMO may cause secondary complement-dependent cytotoxicity (CDC), leading to oligodendrocyte and neuronal damage. …”
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Recent advances in the anti-tumor activities of saponins through cholesterol regulation by Min Jiang, Chao Hong, Chao Hong, Wenkui Zou, Zheng Ye, Lu Lu, Lu Lu, Yun Liu, Yun Liu, Tong Zhang, Tong Zhang, Yue Ding, Yue Ding, Yue Ding

“…It will also outline how saponins exert their anti-cancer activities through cholesterol regulation, enhancing cytotoxicity, inhibiting tumor cell metastasis, reversing drug resistance, inducing immunotoxin macromolecule escape, and ferroptosis. …”
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Hyaluronan Immobilized Polyurethane as a Blood Contacting Material by Feirong Gong, Yue Lu, Hui Guo, Shujun Cheng, Yun Gao

“…APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility. Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation.…”
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Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release by Jinjing Xing, Yeqiang Cai, Yikun Wang, Haifu Zheng, Yujia Liu

“…The effects of different pH values on drug release in vitro were studied by regulating simulated body fluids with different pH values. The cytotoxicity, targeting effect, and drug release of human cervical cancer cell line (HeLa) were studied by cell vitality and imaging experiments. …”
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Control of Nanoparticle Size of Intrinsically Fluorescent PET (Polyethylene Terephthalate) Particles Produced Through Nanoprecipitation by Raffaella Lettieri, Muhammad Mudassir, Fabio Domenici, Andrea Salina, Mariano Venanzi, Cadia D’Ottavi, Elisabetta Di Bartolomeo, Emanuela Gatto

“…These findings provide crucial insights for the detection of nanoplastics in environmental samples through fluorescence measurements and can potentially be used to produce stable PET nanoparticles to evaluate their cytotoxicity.…”
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Micropattern of core-shell Ag@MCS/PEGDA nanoparticles fabricated by femtosecond laser maskless optical projection lithography by Fan-Chun Bin, Xin-Yi Wu, Jie Liu, Xian-Zi Dong, Teng Li, Qi Duan, Jian-Miao Zhang, Katsumasa Fujita, Mei-Ling Zheng

“…Besides, the performance of the surface-enhanced Raman scattering, cytotoxicity, cell proliferation, and antibacterial was investigated on Ag@MP micropatterns. …”
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Potential of peptides and phytochemicals in attenuating different phases of islet amyloid polypeptide fibrillation for type 2 diabetes management by Raliat O. Abioye, Chibuike C. Udenigwe

“…IAPP aggregates, which form amyloid fibrils, contribute to cytotoxicity of the pancreatic β-cells, resulting in loss of function and subsequent reduction in insulin production. …”
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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…This review offers new insights for CPs in molecular mechanisms, cytotoxicity, target selectivity, and the possibility of designing more effective and safe therapeutic agents.…”
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PHYSIOLOGICAL EFFICACY OF MELANIN AS A FOOD INGREDIENT by N. Cherno, A. Kapustian, K. Naumenko, L. Gural, S. Osolina

“…Melanin has a wide range of biological effects that are beneficial to human health, including antioxidant activity, anti-inflammatory and cancer-protective effects, hypoglycemic and antihyperlipidemic properties, etc. It does not show cytotoxicity, side effects or antigenic responses. The various physiological effects of melanin, combined with its biocompatibility and physiological properties as a component of traditional food sources, determine the prospects for the use of melanin as a physiologically functional food ingredient that can play a significant role in human nutrition.…”
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Synthesis and Characterization of Hydrogel-Based Hyaluronic Acid-Chitosan-Allium sativum Extract for Intraperitoneal Antiadhesion Application by Prihartini Widiyanti, Yolanda Citra Ayu Priskawati

“…The composite hydrogel of NOCC/AHA/Allium sativum has susceptible antimicrobial properties. In vitro cytotoxicity assay showed that hydrogel is nontoxic. …”
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Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…The object of this review is to discuss collectively and critically both precedent and more updated data obtained in the lab, the latter arising from assays on DNA status, and gene and protein expression patterns of treated cells, aiming to check whether the cytotoxicity of the peptide may result from a reprogramming of gene expression towards apoptotic death or, instead, it is to be ascribed to an unprogrammed perturbation of cell functions.…”
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HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand. (Niu jiao gua) stem bark and it... by Naphat Kaewpaeng, Sudaporn Wongwan, Khemmachat Pansooksan, Chanakan Chailom, Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Nitra Nuengchamnong, Zhi-Hong Jiang, Li-Ping Bai, Piyarat Srisawang, Supawadee Parhira

“…This will help in predicting its cytotoxicity against HCT116, HepG2 and MKN74. In summary, the established HPLC-ESI-MS method is suitable for both quality control and predicting of CGD anticancer activities for further utilization.…”
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Tattooed human in vitro skin model for testing the biocompatibility of tattoo inks and healing progression after tattooing by Kirsten Reddersen, Deborah Maria Gregersen, Jörg Tittelbach, Cornelia Wiegand

“…Biocompatibility including analysis of cytotoxicity, cytokine release, and gene expression patterns of proinflammatory cytokines, proliferation markers, growth factors and structural components was investigated over a period of 7 days. …”
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The micro(nano)plastics perspective: exploring cancer development and therapy by Xiangying Deng, Yajun Gui, Lin Zhao

“…Microplastics are capable of triggering cytotoxicity and chronic inflammation, and may promote cancer through mechanisms such as pro-inflammatory responses, oxidative stress and endocrine disruption. …”
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Organocatalytic Enantioselective Friedel–Crafts Reaction of Phenanthrenequinones and Indoles by Yan Jin, Yuhong Sun, Yue Yu, Jiao Zhao, Mingshan Zheng, Liming Wang, Ying Jin

“…(<i>S</i>)-<b>4g</b> was found to have optimal cytotoxicity against the A549 cell line and a good safety profile for human normal cells, which was better than the inhibitory activity of the positive control drug (doxorubicin).…”
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Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements by Rania M. Khashaba, Mervet Moussa, Christopher Koch, Arthur R. Jurgensen, David M. Missimer, Ronny L. Rutherford, Norman B. Chutkan, James L. Borke

“…Specimens were characterized using X-ray diffraction, scanning electron microscopy, and infrared spectroscopy. In vitro cytotoxicity of CPCs and control was assessed. Results. …”
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