Application of natural β-glucans as biocompatible functional nanomaterials by Xiaojie Li, Peter Chi Keung Cheung

“…However, the physico-chemically stable and biocompatible properties of β-glucans are rarely explored as a coating material for nanomaterials to overcome the problems of aggregation and cytotoxicity. This article reviews on the exploration of β-glucans, in particular those derived from mushrooms, as a natural coating material to modify the surface properties of bioactive substances as a relatively simple and cost-effective strategy to produce stable and biocompatible nanohybrids used for biopharmaceutical use. …”
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Roles of core fucosylation modification in immune system and diseases by Qiu Pan, Xiao-Lian Zhang

“…Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. …”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…Importantly, the multitarget compounds 6d, 8c, and 8d exhibited remarkable efficacy in simultaneously mitigating Aβ-induced toxicity in SH−SY5Y cells while demonstrating minimal cytotoxicity. Furthermore, predicted ADMET results suggested that 6d, 8c, and 8d possessed favorable pharmacokinetic properties and demonstrated low toxicity levels. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…L1CAM-CAR T cell effector function was assessed (activation markers, cytokine release, tumor cytotoxicity) after coculture with the model or MYCN-amplified neuroblastoma cell lines. …”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…Substituents with opposite electronic effects on the two phenyl rings are preferable for high cytotoxicity against the MCF-7 and A2780 cells. COX inhibition was suggested as the molecular mechanism of the anti-inflammatory activity of the new compounds while no clear relationship could be observed between COX inhibition and anticancer activity. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…AmB was loaded into iPSC-Exos using a co-incubation method. The cytotoxicity of the iPSC-Exo/AmB complex was evaluated on HEK 293 T and RAW264.7 cells using the CCK-8 assay, while apoptosis was assessed using live/dead cell staining and flow cytometry. …”
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Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells by M. I. Doronin, D. A. Lozovoy, V. V. Pronin, D. V. Mikhalishin, V. A. Starikov, A. V. Borisov, A. A. Shishkova

“…Since many types of mycoplasmas affect the genitourinary system organs, to assess the cytotoxicity of Miramistin kidney mammalian cells of various mammals can be used as test systems, in particular, the newborn Syrian hamster (VNK-21), Siberian mountain ibex (PSGK-30), and others. …”
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Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells by Hanan R. H. Mohamed, Esraa H. Ibrahim, Shahd E. E. Shaheen, Nesma O. E. Hussein, Ayman Diab, Gehan Safwat

“…These findings indicate that Ca(OH)2NPs exhibit concentration-dependent cytotoxicity in both normal HSF and cancerous HepG2 cells. …”
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Role of Luminex Crossmatch in Renal Transplantation – A Comprehensive Case Study by Rajeshwari Basavanna, Suchita P. Jogale, Anand S. Deshpande

“…The advent of Complement Dependent Cytotoxicity (CDC) assay, flow cytometry, and solid-phase assays has transformed the detection of anti-HLA antibodies, particularly in renal transplant cases. …”
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Autoimmune Cytopenias in Chronic Lymphocytic Leukemia by Giovanni D'Arena, Roberto Guariglia, Francesco La Rocca, Stefania Trino, Valentina Condelli, Laura De Martino, Vincenzo De Feo, Pellegrino Musto

“…However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. …”
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False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor by Judith Desoutter, Marie-Joëlle Apithy, Ségolène Bartczak, Nicolas Guillaume

“…We consequently detected unexpected Class II IgG complement-dependent cytotoxicity for all sera tested. Other laboratory investigations failed to elucidate the reasons for this recipient-related positivity.…”
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Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus by Youssif Bahaa G. M., Mohamed Yaseen A. M., Salim Mohammed T. A., Inagaki Fuyuhiko, Mukai Chisato, Abdu-Allah Hajjaj H. M.

“…New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized and tested in vitro for antiviral activity against hepatitis C virus (HCV) and hepatitis B virus (HBV). Their cytotoxicity was determined by the reduction in the number of viable cell. …”
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Hypoxanthine Derivatives in Experimental Infections by Claudio De Simone, Edoardo Arrigoni Martelli, Pietro Foresta, Giuseppe Famularo, Roberto Giacomelli, Emilio Jirillo, Vito Ruggiero, Giorgio Tonietti

“…In fact, only the treatment with ST 789 resulted in a clear enhancement of the primary antibody production as well as macrophage phagocytic activity, whereas T lymphocyte responsiveness to mitogens and both macrophage- and natural killer-dependent cytotoxicity were not significantly affected. These data, together with the recently shown ability of ST 789 to increase interleukin-6 production, suggest that monocyte/macrophages are likely to be the main cellular target of the immunomodulating activity of ST 789. …”
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Rhinovirus-Induced Exacerbations of Asthma and COPD by Marc B. Hershenson

“…Exacerbations due to rhinovirus, which infects relatively few cells in the airway and does not cause the cytotoxicity of other viruses such as influenza or respiratory syncytial virus, are particularly poorly understood. …”
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Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells by Chunying Cui, Yaonan Wang, Yuji Wang, Ming Zhao, Shiqi Peng

“…Results revealed that roscovitine exhibited selective cytotoxicity towards 4 cervical carcinoma cells, and the cells showed different morphologic and apoptotic changes at the same concentration. …”
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Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy by Nataliya Kutsevol, Yuliia Kuziv, Tetiana Bezugla, Vasyl Chumachenko, Vasyl Chekhun

“…Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S. …”
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Comparative Metabolic Profiling of Different <i>Raphanus sativus</i> Cultivars and Their Antioxidant and Anti-Inflammatory Activities by Jae Hyeon Kim, Heeju Kim, Minkuk Park, Byeongjun Park, Beomjune Park, Han Yong Park, Gakyung Lee, Jae Sik Yu

“…The extracts of the radish cultivars were tested for their cytotoxicity, antioxidant activity measured with a DPPH assay, and anti-inflammatory activity measured by NO production. …”
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Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy by Shan Wang, Qiang Wang, Yang Lv, Zhe Liu, Kippeum Lee, Dongeun Kim, Miae Won, Jianliang Shen, Jong Seung Kim

“…The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed.…”
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Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. …”
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Phenolics, tannins, flavonoids and anthocyanins contents influenced antioxidant and anticancer activities of Rubus fruits from Western Ghats, India by Kasipandi Muniyandi, Elizabeth George, Saikumar Sathyanarayanan, Blassan P. George, Heidi Abrahamse, Suman Thamburaj, Parimelazhagan Thangaraj

“…Phytochemical exploration of these wild fruits could improve the commercial usage of these Rubus species.This study focuses to analyze the phytochemical, antioxidant and cytotoxicity of three wild Rubus ellipticus, R. niveus and R. fairholmianus fruits comparatively, which has not revealed. …”
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