An In Vitro Study of the Effects of Methotrexate Loaded Biocomposite Beads on MG63 Osteoblast Cells by A. E. Malash, A. A. Al-esnawy, Khairy T. Ereiba, Ahmed M. Bakr, A. S. Abdraboh

“…The profile release of methotrexate was investigated with UV–vis spectroscopy for 30 days. A cytotoxicity study of the methotrexate was performed by a human osteosarcoma (MG-63) cell line. …”
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Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells by Xinlu Wang, Yanyang Xu, Haiqi Yu, Yushun Lu, Yongzhong Qian, Meng Wang

“…Cell viability results showed that the cytotoxicity potency ranking was DON > ZEN > FB₁. …”
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Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…These modified cells demonstrate enhanced cytotoxicity against blasts while minimizing neutrophil elimination. …”
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Effects of asiaticoside on the model of gestational diabetes mellitus in HTR-8/svneo cells via PI3K/AKT pathway by Zhilan Hu, Ya Long, Xiangyue Li, Zhiqin Jia, Mingyan Wang, Xuemei Huang, Xiaolan Yu

“…This study aims to explore the effect of AS on the cell model of GDM and the action mechanism of the PI3K/AKT pathway.Methods The GDM model was established in HTR-8/Svneo cells with a high glucose (HG) medium. After the cytotoxicity assay of AS, cells were divided into the control group, HG group and HG + AS group to conduct control experiment in cells. …”
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Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model by Radka Pecková, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Ivan Petřík, Wisnu Nurcahyo, Ivona Foitová

“…Cultures were counted in a hemocytometer using a light microscope and then statistically evaluated. The cytotoxicity of the extracts was determined by the MTT Cell Viability Assay. …”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…Moreover, KJ015 maintained comparable antibody-dependent cytotoxicity, phagocytosis, and complement-dependent cytotoxicity with trastuzumab plus pertuzumab. …”
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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing by Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti

“…The pCM15 peptide, when incorporated into poloxamer micelles, showed significantly enhanced cytotoxicity against tumor cells. Additionally, the internalization rate of poloxamer-formulated pATIPC peptide by antigen-presenting model cells exceeded that of the unformulated peptide. …”
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Development of fully-resorption replacement paste-like organic/inorganic artificial bones compatible with bone remodeling cycles by Yuki Kamaya, Shiori Kato, Kazuaki Nakano, Masaki Nagaya, Hiroshi Nagashima, Mamoru Aizawa

“…In this study, varying amounts of PLGA particles were added alongside CSH, and the resulting cement's properties, cytotoxicity, and in vivo response large animals (pigs) were assessed. …”
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Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid by Josy Caldas Rodrigues, Weison Lima da Silva, David Ribeiro da Silva, Carolina Rabelo Maia, Clarice Virginia Santos Goiabeira, Haile Dean Figueiredo Chagas, Gigliola Mayara Ayres D’Elia, Gleica Soyan Barbosa Alves, Viviane Zahner, Cecilia Veronica Nunez, Ormezinda Celeste Cristo Fernandes

“…The elucidated molecule was evaluated for cytotoxicity against the human fibroblast strain (MRC5). …”
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Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation by Jin Taek Hwang, Sanghee Kim, Bo-ra Yoon, Inwook Choi, Sang Yoon Choi

“…The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. …”
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Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…The ability of this molecule, termed NKAB-ErbB2, to redirect NKG2D-expressing effector cells to ErbB2-positive tumor cells of different origins was investigated using peripheral blood mononuclear cells, ex vivo expanded NK cells, and NK and T cells engineered with an NKG2D-based chimeric receptor.Results On its own, bispecific NKAB-ErbB2 increased lysis of ErbB2-positive breast carcinoma cells by peripheral blood-derived NK cells endogenously expressing NKG2D more effectively than an ErbB2-specific IgG1 mini-antibody able to induce antibody-dependent cell-mediated cytotoxicity via activation of CD16. Furthermore, NKAB-ErbB2 synergized with NK-92 cells or primary T cells engineered to express an NKG2D-CD3ζ chimeric antigen receptor (NKAR), leading to targeted cell killing and greatly enhanced antitumor activity, which remained unaffected by soluble MICA known as an inhibitor of NKG2D-mediated natural cytotoxicity. …”
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Differential vasoproliferative traits of Bartonella henselae strains associated with autotransporter BafA variants by Yuka Kondo, Masahiro Suzuki, Shingo Sato, Soichi Maruyama, Akiko Sei, Xingyan Ma, Kota Nakano, Yohei Doi, Kentaro Tsukamoto

“…However, BafA variant 2 strains showed cytotoxicity at a high bacterial inoculum in a direct coculture with HUVECs, which was attenuated in an indirect coculture. …”
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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…<b>Methods</b>: In the cytotoxicity study, tumor cells were incubated with ²²⁵Ac-DOTA-RGD₂. …”
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Development of Class IIa Bacteriocins as Therapeutic Agents by Christopher T. Lohans, John C. Vederas

“…The suitability of bacteriocins as pharmaceuticals is explored through determinations of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models. …”
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Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma by Rui Zhang, Yi Zhang, Hairong Xiao, Qingxi Liu, Mingfeng Zhao

“…CAR-T-mediated cytotoxicity was significantly inhibited when IL4I1 was present in the in vitro co-culture model. …”
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Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss) by Samira Salarvand, Seyed Amir Hossein Jalali, Nasrollah Mahboobi Soofiani, Alireza Allafchian

“…The characteristics of modified sodium alginate were evaluated by FTIR, XRD, zeta potential, FE-SEM, EDX, and MAP analysis. Its cytotoxicity was evaluated using an MTT assay. Finally, its effects were assessed orally in rainbow trout (3 ± 0.3 g) for 6 weeks at 2 levels (2.5 and 5 g kg-1). …”
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Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma. by Lei Yang, Kien Pham, Yibo Xi, Qunfeng Wu, Dongfang Liu, Keith D Robertson, Chen Liu

“…This suggest that the presence of different GPC3 isoforms in HCC may impact the cytotoxicity activity of NK92MI/HN3 cells and potentially influence therapeutic outcomes. …”
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Genetic Determinants and Biofilm Properties Useful in Estimation of UTI Pathogenicity of the <i>Escherichia coli</i> Strains Isolated from Free-Living Birds by Bartosz Rybak, Tomasz Jarzembowski, Agnieszka Daca, Beata Krawczyk, Lidia Piechowicz

“…However, the highest cytotoxicity was observed for strains described as aquatic environmental. …”
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Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…In vitro platelet aggregation, antibacterial assays, cytotoxicity tests, and hemolysis evaluations were performed. …”
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Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash by Cristina Aguilera, Marco Viteri, Rachid Seqqat, Ligia Ayala Navarrette, Theofilos Toulkeridis, Ana Ruano, Marbel Torres Arias

“…The in vitro phase was performed in lung cancer cells A549, peritoneal macrophages, and McCoy cells exposing them to different concentrations of volcanic ash (80, 320, and 1280 μg/cm3) to determine the cytotoxicity and the production of reactive oxygen species. …”
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