Unravelling the Digestibility and Structure–Function Relationship of Lentil Protein Through Germination and Molecular Weight Fractionation by Armin Mirzapour-Kouhdasht, Samaneh Shaghaghian, Marjan Majdinasab, Jen-Yi Huang, Marco Garcia-Vaquero

“…This study explores for the first time the impact of a 6-day germination process on the structure (FTIR), antioxidant activity, nutritional/safety attributes (ACE-I inhibitory activity, digestibility, and cytotoxicity), and functional properties of fractions of variable molecular weight (W > 5 kDa; 3 kDa < MW < 5 kDa; and MW < 3 kDa) isolated from proteins extracted from lentils. …”
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Biocompatibility of variable thicknesses of a novel directly printed aligner in orthodontics by Maximilian Bleilöb, Claudia Welte-Jzyk, Vanessa Knode, Björn Ludwig, Christina Erbe

“…UV curing durations were set at 20, 30 and 60 min. Cytotoxicity was evaluated using the AlamarBlue assay on human gingival fibroblasts. …”
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Evaluating the toxicity of sea-dumped conventional and chemical munition degradation products to fish and human cells using a combination of cell viability assays by João Barbosa, Colin R. Janssen, Marijke Neyts, Koen Parmentier, Frédéric Laduron, Kris Geukens, Philippe François, Jana Asselman

“…The results indicate low acute cytotoxicity of CWA&RC, while E&RC exhibit significantly higher toxicity. …”
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Water-Soluble Polymer Assists N-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo by Jie Peng, Jiahui Ma, Xue Yang, Huan He, Haopeng Wu, Tongtong Ma, Jianhua Lu

“…We constructed a water-soluble lipopolymer (WSLP) as a nonviral gene carrier to deliver siRNA targeting NR2B. The cytotoxicity and serum stability of WSLP loaded with siRNA were evaluated, and the knockdown efficiency of WSLP/NR2B-siRNA in PC12 cells was examined. …”
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Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL by Willem P. J. Cox, Noël M. M. Dautzenberg, Linde Dekker, Tesa Klenovsek, Annelisa M. Cornel, Marliek van Hoesel, Dorette S. van Ingen Schenau, Reno S. Bladergroen, Roland P. Kuiper, Laurens T. van der Meer, Friso G. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

“…Moreover, expression analysis in cell lines and xenografts demonstrated that loss of p53 abrogates the expression of the death receptors Fas and death receptor 5 (DR5), both implicated in CAR T cytotoxicity. Conversely, ectopic expression of Fas improved CAR T cytotoxicity. …”
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Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration by Deborah R. Morris, Cathy W. Levenson

“…This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.…”
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Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages by Satoru Yui, Tomoya Kudo, Kazumi Hodono, Yoshihiro Mimaki, Minpei Kuroda, Yutaka Sashida, Masatoshi Yamazaki

“…We previously reported that securiosides A and B, novel triterpene saponins, exerted macrophage-oriented cytotoxicity in the presence of a L-cell-conditioned medium containing macrophage colony-stimulating factor (M-CSF), while the compounds did not exhibit an effect on macrophages in the absence of the growth-stimulating factors.…”
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Impact of HER2-targeting antibody drug conjugates in treatment strategies for patients with breast cancer by Hanghang Ma, Jianbin Li

“…Antibody drug conjugates (ADCs) are novel drugs that exert specific cytotoxicity against breast cancer. Although ADCs such as trastuzumab emtansine and trastuzumab deruxtecan have significantly improved survival for patients with breast cancer expressing HER2, there is still controversy over options after ADCs. …”
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用低分化鼻咽癌细胞株（CNE2）为靶细胞测定鼻咽癌（NPC）患者ADCC作用 by 刘庆伦

“…抗体依赖的细胞介导的细胞毒(AntibodyDependent Cell-Mediated Cytotoxicity,ADCC.)是机体细胞免疫与体液免疫两大系统的协调作用,在机体的肿瘤免疫、移植免疫,某些真菌,病毒,寄生虫疾患及某些自身免疫疾患的过程中,均发挥重要作用。…”
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Discovery of a parallel family of euglenatide analogs in Euglena gracilis by Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher

“…In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides. …”
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Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia by Archana Payickattu Retnakumary, Lekshmi G Kumar, Neeraj Sidharthan, Pavithran Keechilat, Giridharan L. Malarvizhi, Prasanna L Hanumanthu, Madhavan V Thampi, Deepthy Menon, Krishnakumar Menon, Shantikumar V Nair, Manzoor Koyakutty

“…Initial evaluations in drug resistant CML cell lines and patient-derived cells demonstrated significant cytotoxicity. Remarkably, even patients with BCR-ABL oncogene mutations displayed over 95% cytotoxicity with the CS-NPs. …”
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Determination of Adsorption of Methylene Blue Dye by Incense Stick Ash Waste and Its Toxicity on RTG-2 Cells by Virendra Kumar Yadav, Nisha Choudhary, Daoud Ali, Gokhlesh Kumar, G. Gnanamoorthy, Azhar Ulla Khan, Pankaj Kumar, S. Hari Kumar, Belachew Zegale Tizazu

“…The sintered incense stick ash product induced cytotoxicity on RTG-2 cells in a dose-dependent manner. …”
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Antioxidant, Antimicrobial, and Protein Kinase Inhibition Profiling of C. ambrosioides Seed Extracts along with RP-HPLC by Saira Bano, Muhammad Waleed Baig, Mohammad K. Okla, Syeda Saniya Zahra, Nosheen Akhtar, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan-Ul Haq

“…In line with this, in vitro total phenolics and flavonoids content, multimode antioxidants, antimicrobial, cytotoxicity, and protein kinase inhibition assays were conducted on C. ambrosioides seed extracts in addition to RP-HPLC. …”
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Impact of Paracoccus sp. EGY7 carotenoids on triple-negative breast cancer cells: invitro study by Karim Abdelazim, Ahmed Hussein, Sherine N. Khattab, Shaymaa Essam El Feky, Nehad Noby

“…The extract exhibited significant cytotoxicity against MDA-MB-231 cells with an IC50 of 1200 µg. …”
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Topotecan Incorporation Into Avocado Oil-based Nanoemulsion Potentiates Its Inhibitory Effect on the Cellular Growth of Various Human Cancer Cells by Mayson H. Alkhatib, Hadeel M. Bayoumi

“…Background: The aim is to ameliorate the anticancer activity of topotecan (topoisomerase [TOPO]) by solubilizing it in a nanoemulsion (NE) delivery system containing avocado oil (AO), then to assess its cytotoxicity in MCF-7 breast, HCT116 colon, HeLa cervical, and HepG2 liver cancer cells. …”
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Mechanistic insights into endosomal escape by sodium oleate-modified liposomes by Ebrahim Sadaqa, Satrialdi, Fransiska Kurniawan, Diky Mudhakir

“…SO-Lipo enhance endosomal escape through a fusogenic mechanism, facilitating cytosolic delivery with reduced cytotoxicity. This approach offers a safer and more effective option for targeted drug delivery applications.…”
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Evaluation of Carboxymethyl Cellulose/Gelatin Hydrogel-Based Dressing Containing Cefdinir for Wound Healing Promotion in Animal Model by Zahra Soleimani, Hadi Baharifar, Najmeh Najmoddin, Kamyar Khoshnevisan

“…The results of the cytotoxicity test showed the absence of cytotoxicity in both drug-containing and drug-free wound dressings, as well as a survival rate of over 75% in cells after 48 h. …”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…This, in turn, increases their survival, persistence, and cytotoxicity, as well as affects the metabolism of immune cells inside the tumor. …”
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Phytochemical Profiling, Bioactivity, and Insecticidal Effectiveness of <i>Mammea americana</i> L. Leaf Extracts Against <i>Ferrisia</i> sp. by Mike Vázquez-Torres, Nilka Rivera-Portalatín, Irma Cabrera-Asencio

“…The phytochemical composition, potential cytotoxicity, and insecticidal effectiveness of three leaf extracts from the folkloric medicinal plant <i>Mammea americana</i> L. …”
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Nonclinical Similarity of the Biosimilar Candidate ABP 938 with Aflibercept Reference Product by Neungseon Seo, Scott Kuhns, Dina A. Andrews, Alexander Colbert, Vincent Chow, Jennifer Liu

“…No antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, or complement-dependent cytotoxicity was observed with ABP 938 and aflibercept RP. …”
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