New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia by Raha Orfali, Shagufta Perveen

“…All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176. …”
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Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation by Yan Lu, Cheng Chen, Hangyu Li, Peng Zhao, Yuanfeng Zhao, Bohan Li, Wei Zhou, Gaofeng Fan, Dongshi Guan, Yijun Zheng

“…These properties are characterized by minimal cytotoxicity, spatial-temporal controllability, dose dependency, and reversibility. …”
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Engineered CRISPR-Cas9 for Streptomyces sp. genome editing to improve specialized metabolite production by Duck Gyun Kim, Boncheol Gu, Yujin Cha, Jeonghan Ha, Yongjae Lee, Gahyeon Kim, Byung-Kwan Cho, Min-Kyu Oh

“…Abstract The CRISPR-Cas9 system has frequently been used for genome editing in Streptomyces; however, cytotoxicity, caused by off-target cleavage, limits its application. …”
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Enhancing in Vitro anti-metastatic efficacy and deep penetration into tumor spheroid of docetaxel-loaded liposomes via size optimization for prostate cancer treatment by Saksorn Klibaim, Nutthanit Thumrongsiri, Natsorn Watcharadulyarat, Walailuk Chonniyom, Prattana Tanyapanyachon, Paweena Dana, Nattika Saengkrit

“…The results showed significant cellular internalization improvement with smaller LDTX, leading to better cytotoxicity in a monolayer cell culture than with larger LDTX. …”
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A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems by Thuc Ngoc Dinh, Mai Vu Thi Ha, Luong Ngo Xuan, Huan Trinh Thi, Huong Nguyen Thi, Mai Nguyen Thi Ngoc, Giap Tran Huu, Oanh Vu Thi Kim, Thanh Le Nguyen

“…Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. …”
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Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer by Ayuob Aghanejad, Shiva Kheiriabad, Maryam Ghaffari, Simin Namvar Aghdash, Neda Ghafouri, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin

“…The cell study results revealed that Cur-PAMAM-MTX NC exhibited significantly higher cytotoxicity than free MTX, Cur, and other formulations tested in vitro. …”
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The role of size in PEGylated liposomal doxorubicin biodistribution and anti‐tumour activity by Saba Dadpour, Amin Mehrabian, Mahdieh Arabsalmani, Elaheh Mirhadi, Anis Askarizadeh, Mohammad Mashreghi, Mahmoud Reza Jaafari

“…Then, in vitro cellular uptake and cytotoxicity were studied by flow cytometry and MTT assay, and compared with commercially available PLD Caelyx®. …”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Biopharmaceutical studies demonstrated that both compounds were released from NLC in a prolonged and sustained manner, following a biphasic behaviour with an initial fast release followed by a slow phase. Cytotoxicity studies showed selective cytotoxicity in tumoral cell lines, especially in the leukaemia cells, where co-encapsulation resulted in an additive pharmacological effect against individually loaded NLC. …”
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N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells by Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

“…Therefore, we conclude that the simultaneous use of growth/neurotrophic factors and a free radical scavenger may increase overall protection against UPS dysfunction-mediated cytotoxicity and neurodegeneration.…”
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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells by Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang

“…Colorectal tumors with high glutaminase (GLS) expression exhibited reduced T cell infiltration and cytotoxicity, leading to poor clinical outcomes. However, depletion of GLS in CRC cells has minimal effect on tumor growth in immunocompromised mice. …”
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Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study by Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima

“…Here, we investigated the therapeutic potential of secretome derived from dental pulp stem cells (DPSCs) to reduce cytotoxicity and apoptosis caused by amyloid beta (Aβ) peptide. …”
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Polymer Gels Based on PAMAM Dendrimers Functionalized with Caffeic Acid for Wound-Healing Applications by Ricardo I. Castro, Wendy Donoso, Franko Restovic, Oscar Forero-Doria, Luis Guzman

“…The results showed no cytotoxicity and wound-healing activity at a concentration of 20 μg/mL in HaCaT cells with the GPG3Ca. …”
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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells by A. Kleijn, J. J. Kloezeman, R. K. Balvers, M. van der Kaaij, C. M. F. Dirven, S. Leenstra, M. L. M. Lamfers

“…The apoptosis and cytotoxicity assays did not unequivocally detect responses and were excluded from further testing. …”
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Allium cepa Bio Assay to Assess the Water and Sediment Cytogenotoxicity in a Tropical Stream Subjected to Multiple Point and Nonpoint Source Pollutants by W. M. Dimuthu Nilmini Wijeyaratne, L. G. Y. J. G. Wadasinghe

“…The present study was conducted to assess the cytotoxicity of water and sediments of an industrial effluent receiving water body in the western province of Sri Lanka using Allium cepa bioassay. …”
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Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization by Feng Zhao, Wenlei Fei, Zhouyue Li, Hanyang Yu, Lei Xi

“…The present study is aimed at investigating the cytotoxicity and antiangiogenic effects of PEDF-loaded PEGylated nanoparticles (NP-PEG-PEDF) on high glucose-stimulated human umbilical vein endothelial cells (HUVECs). …”
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Investigating the Medicinal Potential of Lavatera cashmeriana Leaf Extract: Phytochemical Profiling and In Vitro Evaluation of Antimicrobial, Antioxidant, and Anticancer Activities by Mohmmad Ashaq Sofi, Mohd Abass Sofi, Anima Nanda, Kasi Thiruvengadam, B. K. Nayak

“…The 2,2-diphenyl-1-picrylhydrazyl assay was conducted to assess antioxidant capabilities, while cytotoxicity against the A549 cancer cell line was determined via the MTT assay. …”
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In Vitro Comparison of the Effect of Three Types of Heat-Curing Acrylic Resins on the Amount of Formaldehyde and Monomer Release as well as Biocompatibility by Homeira Ansari lari, Saman Hakimi Jahed, Kamyar Abbasi, Mostafa Alam, Mohammad Alihemmati, Ali Jamali Ghomi, Mahdi Rahbar, Seyed Ali Mosaddad, Reza Sayyad Soufdoost, Reza Eftekhar Ashtiani

“…The biocompatibility and cytotoxicity of formaldehyde and monomer are essential in resin-based denture’s byproducts. …”
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Preparation, characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken, porcine and bovine by Liwei Qi, Hongru Zhang, Yujie Guo, Hong Liu, Chunhui Zhang

“…In this study, 3 glycosylated bone collagen hydrolysates were prepared and characterized, and cytotoxicity and antioxidant activity were analyzed and evaluated. …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…Selections were performed for cytotoxicity, proliferation, memory formation, and persistence on repeated antigen challenge.Results Each enriched CAR robustly produced the phenotype for which it was selected, and one enriched CAR triggered potent cytotoxicity and long-term proliferation on in vitro tumor rechallenge. …”
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Effect of nanoparticulate CaCO3 on the biological properties of calcium silicate cement by Quang Canh Vo, Gitae Son, Gyeung Mi Seon, Sun Woo Um, Sang Hoon Choi, Hyeong-Cheol Yang

“…The average size of NPCC was 90.3±26.0 nm. Cytotoxicity and osteogenic activity assays were performed using mouse bone marrow mesenchymal stem cells (BMSCs). …”
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