The role of mitochondrial dysfunction in the cytotoxic synergistic effect of gemcitabine and arsenic on breast cancer by Farshid Maleki, Somayeh Handali, Mohsen Rezaei

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Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins

“…The findings suggest that the observed cytotoxicity of the lanthanum complex of <mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L1 on BV-173 is at least partly mediated through induction of programmed cell death.…”
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The role of mitochondrial dysfunction in the cytotoxic synergistic effect of gemcitabine and arsenic on breast cancer. by Farshid Maleki, Somayeh Handali, Mohsen Rezaei

“…In this regard, we evaluated the effectiveness of combined treatment with gemcitabine (GCB) and arsenic (ATO) and how they affect the cell death pathway in cancer cells. Cytotoxic activity of drugs individually or combined against MDA-MB-231 and MCF-7 was performed by MTT method and isobolographic analysis was used to determine the interaction between these factors. …”
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Natural Cytotoxicity Receptors in Decidua Natural Killer Cells of Term Normal Pregnancy by Hideki Takahashi, Tatsuo Yamamoto, Motomi Yamazaki, Takayuki Murase, Takayuki Matsuno, Fumihisa Chishima

“…To investigate the changes in the maternal immune system at term pregnancy, we studied the expression of natural cytotoxicity receptors (NCRs) and the cytokine production of NK cells in term placenta decidua and peripheral blood. …”
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Lanostane Triterpenes, Flavanones and Acetogenins from the Roots of Uvaria siamensis and Their Cytotoxic Activity by Lueacha Tabtimmai, Kiattawee Choowongkomon, Prasat Kittakoop, Ratsami Lekphrom, Florian Thierry Schevenels, Supachai Jadsadajerm, Awat Wisetsai

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Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes by Nhareet Somchit, Chong Sock Ngee, Azhar Yaakob, Zuraini Ahmad, Zainul Amiruddin Zakaria

“…SKF 525A had no effects on the cytotoxicity of fluconazole. Curcumin failed to either increase or decrease the cytotoxicity of both antifungal drugs. …”
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Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc by Ines Mrakovcic-Šutic, Biserka Radoševic-Stašic, Marija Šimin, Damir Muhvic, Daniel Rukavina

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The Effect of Surface Functionalization of Magnesium Alloy on Degradability, Bioactivity, Cytotoxicity, and Antibiofilm Activity by Morena Nocchetti, Michela Piccinini, Donatella Pietrella, Cinzia Antognelli, Maurizio Ricci, Alessandro Di Michele, Layla Jalaoui, Valeria Ambrogi

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Discovery of 2‑Pyrazolines That Inhibit the Phosphorylation of STAT3 as Nanomolar Cytotoxic Agents by Tejaswini P. Siddappa, Akshay Ravish, Zhang Xi, Arunkumar Mohan, Swamy S. Girimanchanaika, Niranjan Pattehali Krishnamurthy, Shreeja Basappa, Santosh L. Gaonkar, Peter E. Lobie, Vijay Pandey, Basappa Basappa

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PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF LEAF EXTRACT OF Dipteryx lacunifera DUCKE by Krislany A. L. Guedes Araujo, Herbert G. Sousa, João P. da Silva Gomes, Renato Pinto de Sousa, Éverton L. de França Ferreira, Monica T. Pupo, Pedro M. da Silva Costa, Claudia Pessoa, Mahendra Rai, Mariana H. Chaves, Gerardo Magela Vieira Junior

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Effect of Glycoconjugation on Cytotoxicity and Selectivity of 8-Aminoquinoline Derivatives Compared to 8-Hydroxyquinoline by Gabriela Pastuch-Gawołek, Julia Szreder

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Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves by Letiele Bruck de Souza, Amanda Leitão Gindri, Thainara de Andrade Fortes, Thais Felli Kubiça, Jefferson Enderle, Rafael Roehrs, Sidnei Moura e Silva, Vanusa Manfredini, Elton Luís Gasparotto Denardin

“…This work was to evaluate the chemical constitution of the hydromethanolic (30/70 methanol-water) macerating extract obtained from the leaves of C. nutans, as well as to study the antioxidant, antimicrobial, cytotoxic, and genotoxic activity of the species. Materials and methods. …”
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Synthesis, Cytotoxicity, and Antileishmanial Activity of N,N'-Disubstituted Ethylenediamine and Imidazolidine Derivatives by Gustavo S. G. de Carvalho, Patrícia A. Machado, Daniela T. S. de Paula, Elaine S. Coimbra, Adilson D. da Silva

“…In addition, none of compounds were cytotoxic against mammalian cells. The leishmanicidal activity can be related with inhibition of polyamine synthesis and cellular penetration within biological membranes.…”
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Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves by Rashad Alsanosy, Hassan A. Alhazmi, Shahnaz Sultana, Ashraf N. Abdalla, Yassin Ibrahim, Mohammed Al Bratty, David Banji, Ibrahim Khardali, Asaad Khalid

“…All extracts showed comparable cytotoxicity, IC50 ranging from 22–59 μg/mL on the cancer cells; however, we observed more cytotoxicity against normal cells (IC50: 6–41 μg/mL). …”
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Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin by Yulia N. Nosova, Ilia V. Zenin, Varvara P. Maximova, Ekaterina M. Zhidkova, Kirill I. Kirsanov, Ekaterina A. Lesovaya, Anna A. Lobas, Mikhail V. Gorshkov, Olga N. Kovaleva, Elena R. Milaeva, Markus Galanski, Bernhard K. Keppler, Alexey A. Nazarov

“…We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. …”
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Anticancer potential of coumarins from the Ferulago genus by Mansour Mofasseri, Elham Eini, Saber Mofasseri, Bahram Hanifehpour, Fatemeh Zanbili, Ahmad Poursattar Marjani

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Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives by França Paulo H. B., Da Silva-Júnior Edeildo F., Aquino Pedro G. V., Santana Antônio E. G., Ferro Jamylle N. S., De Oliveira Barreto Emiliano, Do Ó Pessoa Cláudia, Meira Assuero Silva, De Aquino Thiago M., Alexandre-Moreira Magna S., Schmitt Martine, De Araújo-Júnior João X.

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Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs by Gesham Magombedze, Winston Garira, Eddie Mwenje

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Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC) by M. Jäpel, H. Lötzerich, K. Rogalla

“…Therapeutically effective concentrations of ASA, which are known to decrease levels of prostaglandins, had neither a stimulating nor an inhibiting influence on antibody-dependent cellular cytotoxicity (ADCC) or on the binding capacity of macrophages with regard to SW 948 tumour cells. …”
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Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer by Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Emily Eul, Jiayu Ye, Qihao Ren, David Clever, Julia Wang, Pamela Wong, Michael S. Haas, Sheila A. Stewart, Cynthia X. Ma, Todd A. Fehniger, Roberta Faccio

“…Importantly, increased DKK1 levels and reduced cytotoxic NK cells are detected in women with progressive breast cancer. …”
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