Dual Roles of IL-27 in Cancer Biology and Immunotherapy by Marina Fabbi, Grazia Carbotti, Silvano Ferrini

“…Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential. …”
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Immunomodulatory Effect of Bisphosphonate Risedronate Sodium on CD163+ Arginase 1+ M2 Macrophages: The Development of a Possible Supportive Therapy for Angiosarcoma by Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Aya Kakizaki, Setsuya Aiba

“…An imbalance of immunosuppressive cells and cytotoxic cells plays an important role in inhibiting the antitumor immune response of the tumor-bearing host. …”
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Biomarkers in metastatic castration-resistant prostate cancer for efficiency of immune checkpoint inhibitors by Zixi Wu, Junbiao Zhang, Le Li, Zhihua Wang, Chunguang Yang

“…However, while immune checkpoint inhibitor monotherapy or combination therapy targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and/or programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) axis has been regarded as the standard therapy in many solid tumours, mCRPC as ‘cold’ tumours are considered to be relatively resistant to ICB treatment. …”
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A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

“…Cell viability was assessed using the EZ-Cytotoxic kit, while colony formation assays and TUNEL staining were used to meas-ure proliferation and apoptosis, respectively. …”
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Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…Finally, we performed in vivo experiments to further investigate the inflammation.ResultsNEO exhibits no significant cytotoxic effects on BMMs at concentrations less than or equal to 30 μM while exerting inhibitory effects on OC differentiation during its early and middle stages. …”
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Polyclonal Recipient nTregs Are Superior to Donor or Third-Party Tregs in the Induction of Transplantation Tolerance by Nina Pilat, Christoph Klaus, Karin Hock, Ulrike Baranyi, Lukas Unger, Benedikt Mahr, Andreas M. Farkas, Fritz Wrba, Thomas Wekerle

“…We have previously reported successful induction of chimerism and tolerance using cell therapy with recipient T regulatory cells (Tregs) to avoid cytotoxic recipient treatment. Treg therapy is limited by the availability of cells as large-scale expansion is time-consuming and associated with the risk of contamination with effector cells. …”
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Plasmapheresis for extracorporeal membrane oxygenation (ECMO)-induced hemolysis in infants by Budhu Gail, Morris-Whyte Kaydeen, Constantinescu Alexandru R.

“…Characterized by elevated plasma-free hemoglobin (PFH), intravascular hemolysis is associated with cytotoxic effects leading to renal replacement therapy (RRT), longer ECMO runs, and mortality. …”
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Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies by Amirata Mohseni, Fatemeh Salehi, Samaneh Rostami, Kaveh Hadiloo, Mehrdad Hashemi, Zahra Baridjavadi, Fatemeh Ahangari, Najibeh Karami, Fatemeh Samani, Safa Tahmasebi, Najma Farahani, Afshin Taheriazam

“…Additionally, immune cell-derived exosomes, such as those from Natural Killer (NK) cells or cytotoxic T lymphocytes (CTLs), show potential as therapeutic agents in treating malignancies like leukemia. …”
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Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells by Anine Crous, Elvin Chizenga, Natasha Hodgkinson, Heidi Abrahamse

“…Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells. …”
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Potential Health Implications of the Consumption of Thermally-Oxidized Cooking Oils – a Review by Falade Ayodeji Osmund, Oboh Ganiyu, Okoh Anthony Ifeanyi

“…Thermal oxidation of edible oils had since attracted great attention of nutritionist and researchers given the deteriorative effect such as generation of very cytotoxic compounds, loss of carotenoid, phenolics and vitamins thus reducing the overall antioxidant properties of the oils. …”
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Transcriptomic Response in Pseudomonas aeruginosa towards Treatment with a Kaempferol Isolated from Melastoma malabathricum Linn Leaves by Mourouge Saadi Alwash, Wan Syaidatul Aqma, Wan Yaacob Ahmad, Nazlina Ibrahim

“…The results also revealed that KF decreased the expression of a broad range of virulence factors associated with LPS biosynthesis, iron homeostasis, cytotoxic pigment pyocyanin production, and motility and adhesion that are representative of an acute P. aeruginosa infection profile. …”
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Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric nanoparticles by Shota Yamamoto, Chia-Jung Chang, Masao Kamimura, Jun Nakanishi

“…Cytotoxic agents targeting the epidermal growth factor receptor (EGFR) exhibit significant potential for cancer therapy as EGFR is overexpressed in various cancers. …”
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Eco-biofabrication of silver nanoparticles from Azadirachta indica, Gymnema sylvestre, and Moringa oleifera for lung cancer treatment by Tanya Muthu, Ravi Adusumalli, Sathish Kumar Vemuri, M. Indira Devi, P. Pavan Kumar, Rajkiran Reddy Banala, A. V. Gurava Reddy

“…The synthesized AgNPs exhibited potent cytotoxic activity against A549 cells, with enhanced efficacy compared to the leaf extracts alone. …”
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Evaluating Antimicrobial Effectiveness of Gold Nanoparticles against Streptococcus oralis by Batool M Al-Fahham, Rafeef Ahmed Mohamed, Juman Mohammed Taqi Al-Talqani, Ali Hadi Fahad, Julfikar Haider

“…For instance, gold nanoparticles (Au NPs) are found to be successful to control and limit the bacterial pathogenicity in the oral cavity without any cytotoxic effects on the human body. Aim. In this paper, it was aimed to detect the antibacterial effect of Au NPs and compare with chlorhexidine (CHX) against Streptococcus oralis (S. oralis) in dental plaque of patients with chronic periodontitis. …”
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GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma by Yi Sun, Enze Li, Wenzhao Zhong, Zhaoming Deng, Ziyao Zhou, Ka Hong Wong, Xiangwei Li

“…Additionally, the induction of ICD facilitates dendritic cell maturation and cytotoxic T lymphocyte infiltration, providing durable anti-tumor immunity. …”
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Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…CD27-CD70 is a receptor-ligand complex which enhances T helper and cytotoxic T cell activation, survival, and proliferation. …”
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Healthcare waste management practices in rural state hospitals, Ampara, Sri Lanka by Kulanga Warnakulahewa, Inoka Suraweera, Prasanga Serasinghe

“…Hazardous waste consists of sharp objects, infectious materials, pharmaceuticals, biological substances, cytotoxic agents, chemicals and radioactive materials. …”
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Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo by Sura Akram, Ahmed Majeed Al-Shammari, Hayder B. Sahib, Majid Sakhi Jabir

“…In vitro, results showed that the combination therapy induces synergistic cytotoxicity and apoptosis against cancer cells with a negligible cytotoxic effect on normal cells. …”
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A review on intrathecal administration of medications for leptomeningeal metastases in solid tumors by Xuemei Wang, Chi Yao, Li Quan, Junxiang Zhou

“…Moreover, a low-dose medication can achieve a higher drug concentration in the CSF, resulting in better cytotoxic effects. Chemotherapy drugs such as methotrexate, cytarabine, and thiotepa have been widely studied as traditional IT therapies. …”
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Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients by Suzanne Samarani, Patrick Sagala, Prevost Jantchou, Guy Grimard, Christophe Faure, Colette Deslandres, Devendra K. Amre, Ali Ahmad

“…We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients. …”
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