Multifunctional Nanoparticles as Radiosensitizers to Overcome Hypoxia-Associated Resistance in Cancer Radiotherapy by Ming-Hong Chen, Hon-Pan Yiu, Yu-Chi Wang, Tse-Ying Liu, Chuan Li

“…This study demonstrates that low cytotoxic SPIO@PFH-CHC nanodroplets can be an efficient radiosensitizer for radiation therapy.…”
Get full text

Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma by Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk

“…The analysis showed that DC-CIK cells exerted a significant cytotoxic effect on the glioblastoma cell lines, especially with the phenotype of stem-like cells (GSCs). …”
Get full text

Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…We observe a synergistic cytotoxic effect on erlotinib-resistant cells. Moreover, motility assays show that the compounds combination significantly impedes the motility of all cells. …”
Get full text

The Effects of Forodesine in Murine and Human Multiple Myeloma Cells by Liesbeth Bieghs, Jo Caers, Elke De Bruyne, Els Van Valckenborgh, Fiona Higginbotham, Karin Vanderkerken, Eline Menu

“…Forodesine might be however potentiating towards other established cytotoxic drugs in MM.…”
Get full text

Evaluation of Tinospora cordifolia stem extract bioactive content and anticancer activity against breast cancer cells by Annisa Yuslinda, Rosyadah Nuraini, Kamila Fairuz Sarah, Ulfa Siti Mariyah, Lestari Sri Rahayu, Widodo Nashi

“…This study aims to explore the bioactive potential of Tinospora cordifolia stem extract by investigating the content of flavonoids, phenols, terpenoids and alkaloids as well as the cytotoxic and apoptotic effects on T47D breast cancer cells. …”
Get full text

Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality by Noura Al-Dayan, Divya Venugopal, Sugapriya Dhanasekaran

“…Activation of virus-specific CD4+ T cells and CD8+ cytotoxic T cells selectively targets the infected cells and strengthens the immunoregulatory system. …”
Get full text

Hemophagocytic Lymphohistiocytosis Complicating Dengue and Plasmodium vivax Coinfection by Muhammad Khurram, Muhammad Faheem, Muhammad Umar, Asif Yasin, Wajeeha Qayyum, Amna Ashraf, Javeria Zahid Khan, Ali Hasnain Yasir, Yusra Ansari, Muhammad Asad, Iram Khan, Shuja Abbas, Irum Rasheed, Natasha Rasool, Hamama Tul Bushra Khar

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder. Dysfunction of cytotoxic T and natural killer (NK) cells causes uncontrolled activity of lymphocytes and histiocytes which leads to HLH. …”
Get full text

Herbicide Widespread: The Effects of Pethoxamid on Nonalcoholic Fatty Liver Steatosis In Vitro by Anna Virginia Adriana Pirozzi, Antonietta Stellavato, Chiara Schiraldi, Mariateresa Giuliano

“…Due to similarities to glyphosate, we did look at the effect of pethoxamid on impaired liver cells HepG2, using a nonalcoholic fatty liver disease (NAFLD) cell model in vitro. Pethoxamid was cytotoxic starting at 1 ppm. Fatty acid accumulation (FA) was enhanced while low doses of pethoxamid slightly decreased LDH protein expression compared to FA-treated HepG2. …”
Get full text

POTENCY OF SOURSOP LEAF EXTRACT AND CURCUMIN WITH MAGNETIC AND MUCUS-PENETRATING NANOPARTICLE AS COLORECTAL CANCER ALTERNATIVE THERAPY by Faiza Rahma Ebnudesita, Ayik Rochyatul Jannah, Savira Butsainah Dienanta, Reny I'tishom

“…Review: Soursop leaf extract has acetogenin agent as an anti-tumor, anti-inflammatory, and cytotoxic agent that acts specifically on target organs. …”
Get full text

Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis by Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh

“…In most cases, iNKT cells exert regulatory or direct cytotoxic roles to protect hosts against parasite infections. …”
Get full text

Therapeutic Potential of Acanthospermum hispidum: A Comprehensive Analysis of Its Antimicrobial, Antioxidant, and Anticancer Properties by Ehssan H. Moglad, Alshaimaa A. Alnoor, Nagla M. Eltayeb, Eshtiyag A. Abdalkareem, Amna Ali, Magbool E. Oraiby, Shahnaz Sultana, Asaad Khalid, Ashraf N. Abdalla

“…Free radical scavenging was investigated out by using the DPPH method. Cytotoxicity assay was performed against human breast cancer cell line MCF7 using the MTT assay. …”
Get full text

Lessons Learned from Experimental Human Model of Zinc Deficiency by Ananda S. Prasad

“…In an experimental model of human mild zinc deficiency, we reported decreased thymulin (a thymopoietic hormone) activity in Th1 cells, decreased mRNAs of IL-2 and IFN-gamma genes, and decreased activity of natural killer cells (NK) and T cytotoxic T cells. The effect of zinc deficiency on thymulin activity and IL-2 mRNA was seen within eight to twelve weeks of the institution of zinc-deficient diet in human volunteers, whereas lymphocyte zinc decreased in 20 weeks and plasma zinc decreased in 24 weeks after instituting zinc-deficient diet. …”
Get full text

Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and... by Jonnie N. Asegbeloyin, Oguejiofo T. Ujam, Emmanuel C. Okafor, Ilknur Babahan, Esin Poyrazoglu Coban, Ali Özmen, Halil Biyik

“…The compounds were screened for their in vitro cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. …”
Get full text

Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease by Jacob Favret, Malabika Maulik, Rayan Masoom, Meghana Kushwaha, Devin Thompson, Richard Browne, Daesung Shin

“…Krabbe disease (KD) is a neurodegenerative lysosomal disorder caused by a galactosylceramidase (GALC) deficiency, accumulating cytotoxic psychosine in nervous systems, and subsequent neuroinflammation. …”
Get full text

The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation by Bin Yang, Dike Shi, Yahong Chen, Yi Zhu

“…The results of GSEA revealed that multiple immune-related pathways were enriched in the IF/TA group, and subsequent immune landscape analysis also showed that the IF/TA group had higher immune and stromal scores and up to 15 types of immune cells occupied them, such as B cells, cytotoxic cells, and T cells. LASSO regression analysis selected 6 (including ANGPTL3, APOH, LTF, FCGR2B, HLA-DQA2, and EGF) out of 14 DE-IRGs as diagnostic genes to construct a diagnostic model. …”
Get full text

Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Though the pathogenesis is not fully known, HLH is understood to be a reactive process in the setting of uncontrolled activation of macrophages, CD8+ cytotoxic lymphocytes, and other immune cells. Hallmark clinicopathological features of HLH include fevers, cytopenias, hepatosplenomegaly, and hemophagocytosis in the bone marrow. …”
Get full text

Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…In this study, we predicted HLA-A∗0201-restricted cytotoxic T lymphocyte (CTL) epitopes of MAGE-A4, followed by peptide/HLA-A∗0201 affinity and complex stability assays. …”
Get full text

Enhancement of the Antibacterial Efficiency of Silver Nanoparticles against Gram-Positive and Gram-Negative Bacteria Using Blue Laser Light by Anes Al-Sharqi, Kasing Apun, Micky Vincent, Devagi Kanakaraju, Lesley Maurice Bilung

“…The mechanism of interactions between Ag-NPs and the bacterial cell membranes was then evaluated via scanning electron microscopy (SEM) and reactive oxygen species analysis to study the cytotoxic action of photoactivated Ag-NPs against both bacterial species. …”
Get full text

Preservation of Aquatic Environmental DNA Using Cationic Detergents by Viresh Thamke, Yared H. Bezabhe, Jana Jass, Per‐Erik Olsson

“…The preservation of mtDNA by cationic surfactants was attributed to their bactericidal and cytotoxic properties as well as their electrostatic interaction with DNA molecules, as observed by spectrofluorometric analysis and subsequent precipitation. …”
Get full text

Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer by Ruohong Lin, Jiaxing Cheng, Jinlong Zhao, Liang Zhou, Jian Li, Xinchun Yang

“…Objective To evaluate the therapeutic efficacy of the combination of the anti-angiogenic drug PEP06 (TB01) and the cytotoxic drug Trifluridine/Tipiracil (TAS-102) in human CRC HCT-116 xenograft mouse model. …”
Get full text