Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research by Xiangfei Su, Mi Zhang, Hong Zhu, Jingwen Cai, Zhen Wang, Yuewei Xu, Li Wang, Chen Shen, Ming Cai

“…In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic capability, long-lasting immune memory, and adaptability within immunotherapeutic approaches. …”
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Spectroscopic, Diagnostics, and Surface Modification of Stainless Steel Doped with Ti Plasma Produced by DC Magnetron Sputtering and Used in Biomedical Applications by Mustafa A. Mahmood, Riyam Adnan Hammudi

“…The doped sample was subjected to a bioactivity test. The cytotoxicity results demonstrate a significant cytotoxic effect on CHO cells, which could be attributed to the high concentration of metal ions produced by the material's biocorrosion, which causes the culture medium's pH to change quickly, as indicated by a change in colour.…”
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A New Unsaturated Aliphatic Anhydride from Aspergillus candidus T1219W1, an Endophytic Fungus, from Pittosporum mannii Hook f. by Gaëlle Talle Juidzou, Elodie Gisèle Mouafo Anoumedem, Denis Kehdinga Sema, Virginie Flaure Tsague Tankeu, Peron Bosco Leutcha, Larissa Yetendje Chimi, Jean Paul Dzoyem, Simeon Kouam Fogue, Norbert Sewald, M. Iqbal Choudhary, Alain Meli Lannang

“…However, no cytotoxic activity was observed against 3T3 cell lines.…”
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Immunoinformatic approach to the design of a novel multi-epitope vaccine against Leishmania major fused to human IgG-Fc by Mahmood Fadaie, Zabihollah Shahmoradi, Hossein Khanahmad

“…Immune simulation results showed significant increases in IgM and IgG antibody levels following three vaccinations, along with enhanced activation of B cells, helper T cells, and cytotoxic T lymphocytes. Conclusion and implications: These findings provide novel insights for developing effective candidates for cutaneous leishmaniasis vaccines. …”
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A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η1-C2H4OMe)(DMSO)(phen)]+ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells... by Federica De Castro, Erika Stefàno, Erik De Luca, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Pt-EtOMeSOphen showed higher cytotoxic effects than cisplatin in most of the cancer cell lines and in particular against the neuroblastoma cell line (SH-SY5Y). …”
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The role of reaction temperature in synthesizing clove-derived copper oxide nanoparticles for brain cancer treatment by Mehrnoosh Fakhredin, Fatemeh Shariatmadar Tehrani, Maryam Aliannezhadi

“…The CuO NPs displayed remarkable anti-cancer activity against the C6 cell line, with increased drug concentrations in the wells resulting in high cytotoxicity. Significant cytotoxic effects were observed with the selected CuO NPs at a concentration of 35 µ g/mL.…”
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Mediators of Inflammation in Topical Therapy of Skin Cancers by Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin, Constantin Caruntu

“…Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4. Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest.…”
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Cancer vaccines: platforms and current progress by Wanting Lei, Kexun Zhou, Ye Lei, Qiu Li, Hong Zhu

“…Preventive cancer vaccines, like those against HPV and HBV, reduce the incidence of virus-associated cancers, while therapeutic cancer vaccines aim to activate dendritic cells and cytotoxic T lymphocytes for durable anti-tumor immunity. …”
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Cliotide U1, a Novel Antimicrobial Peptide Isolated From Leaves by Mahnaz Nasre Taheri, Sima Sadat Seyedjavadi, Mehdi Goudarzi, Gholamhossein Ebrahimipour, Ali Hashemi

“…The properties of the peptide, including antibacterial activity, pH stability, heat stability, cytotoxicity, and hemolytic activity, were also examined. …”
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Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity by Marco Mellado, Carlos Jara, David Astudillo, Joan Villena, Patricio G. Reveco, Franz A. Thomet

“…In addition, 1 and 2 exhibited cytotoxic activity in the same range as oxaliplatin toward the two human tumor cell lines (MCF-7 and HT-29) studied and two to four times lower activity in the human colon nontumor cell line (CCD-841). …”
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Cellular and metabolic impacts of repeated sub-acute exposures to biomass-burning extracts in vitro by Michal Pardo, Chunlin Li, Amani Jabali, Yinon Rudich

“…Using representative cell lines for different tissues, we examined the cytotoxic effects under conditions mimicking sub-acute environmental exposure levels relevant to humans. …”
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Effects of Metalloporphyrins on Heme Oxygenase-1 Transcription: Correlative Cell Culture Assays Guide in Vivo Imaging by Monica Hajdena-Dawson, Weisheng Zhang, Pamela R. Contag, Ronald J. Wong, Hendrik J. Vreman, David K. Stevenson, Christopher H. Contag

“…In vitro BLI showed ZnPP to be a strong inducer of HO-1 transcription in comparison to ZnBG, which showed minimal induction. Cytotoxicity studies revealed that ZnPP was phototoxic, whereas ZnBG had no effect on cell viability. …”
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BONE MARROW MICROENVIRONMENT INVOLVEMENT IN T-MN: FOCUS ON MESENCHYMAL STEM CELLS by Maria Teresa Voso, Giulia Falconi, Emiliano Fabiani

“… Therapy-related myeloid neoplasms (t-MN) are a late complication of cytotoxic therapy (CT) used in the treatment of both malignant and non-malignant diseases. …”
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Accelerated aging modulates the toxicological properties of the diazo tattoo pigment PO13 by Lise Aubry, Marianne Vitipon, Aurélie Hirschler, Hélène Diemer, Thierry Rabilloud, Christine Carapito, Thierry Douki

“…Conversely, DCBP was cytotoxic and induced the production of ROS, but was not genotoxic. …”
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The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion by Huang Shuaishuai, Cui Pinger, Lin Shuangxia, Yao Xuping, Wang Xue, Ren Yu, Weng Guobin

“…The MTT assay was used to study the cytotoxic effects of sorafenib. Cell invasion and migration were assayed in wound healing and transwell experiments, respectively. …”
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Translocation (6;15)(q12;q15): A Novel Mutation in a Patient with Therapy-Related Myelodysplastic Syndrome by Saba F. Ali, Rebecca J. Sonu, Denis M. Dwyre, Brian A. Jonas, Hooman H. Rashidi

“…Patients with t-MDS, a group of heterogeneous stem cell related disorders resulting as a latent complication of cytotoxic and/or radiation therapy, generally tend to have a poorer prognosis than de novo MDS. …”
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Photochemical Treatment of Drosophila APCs Can Eliminate Associated Viruses and Maintain the APC Function for Generating Antigen-Specific CTLs Ex Vivo by Jun Ye, Chunxia Yang, Zeling Cai, Weixing Shi, Hong Yu

“…Drosophila cells transfected with MHC class I and a number of costimulation molecules including B7.1, ICAM, LFA-3, and CD70 are potent antigen-presenting cells (APCs) for the generation of antigen-specific cytotoxic T cells (CTLs) in vitro. Using Drosophila APCs, CTLs specific for melanoma antigens have been generated in vitro and adoptively transferred to melanoma patients. …”
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Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents:... by Karunganathan Sakthikumar, Rui Werner Maçedo Krause, Bienfait Kabuyaya Isamura

“…The in vitro antibacterial, cytotoxic, and radical scavenging characteristics revealed that complex (1a) has the best biological efficacy compared to others. …”
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A mathematical model of HTLV-I infection with two time delays by Xuejuan Lu, Lulu Hui, Shengqiang Liu, Jia Li

“…In this paper, we include two time delays in a mathematical model for the CD8$^+$ cytotoxicT lymphocytes (CTLs) response to the Human T-cell leukaemia virus type I (HTLV-I) infection,where one is the intracellular infection delay and the other is the immune delay to account for aseries of immunological events leading to the CTL response. …”
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Monitoring the Induction of Heat Shock Factor 1/Heat Shock Protein 70 Expression following 17-Allylamino-Demethoxygeldanamycin Treatment by Positron Emission Tomography and Optical... by Mikhail Doubrovin, Jian T. Che, Inna Serganova, Ekaterina Moroz, David B. Solit, Lyudmila Ageyeva, Tatiana Kochetkova, Nagavarakishore Pillarsetti, Ronald Finn, Neal Rosen, Ronald G. Blasberg

“…The HSF1 reporter system can be used to screen anticancer drugs for induction of cytotoxic stress and HSF1 activation both in vitro and in vivo.…”
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