Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies by Armin Sepp, Morris Muliaditan

“…This methodology can help to evaluate the efficacy and safety properties of novel drugs, especially if the off-target cell degradation has cytotoxic outcomes, as in the case of antibody-drug conjugates.…”
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Application of Biodegradable Polyhydroxyalkanoates as Surgical Films for Ventral Hernia Repair in Mice by Yun Chen, Ya-Hui Tsai, I-Ning Chou, Sheng-Hong Tseng, Ho-Shing Wu

“…The cytotoxicity and biosafety of poly-(3-hydroxybutyrate) (P3HB) and poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (P3HBV) films were investigated in vitro using 3T3 fibroblast cells and in vivo through subcutaneous implantation of the film in mice. …”
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ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs by Siwei Luo, Amber Notaro, Lan Lin

“…This technology isolates and characterizes activated T cells via an aptamer-based fluorescent molecular sensor, which monitors the cytotoxic cytokine IFNγ secretion from single T cells upon antigen stimulation, followed by single-cell RNA and single-cell TCR sequencing. …”
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Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1 by Zhaoming zhang, Xinyue Yu, Guanghui Cheng

“…We found that vitamin D sensitized vitamin D receptor (VDR)-positive CC cells (Siha and Caski) to the cytotoxic effects of radiation in vivo and in vitro. …”
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Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis by Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie

“…In addition, SA inhibited transcriptional activity of activating transcription factor 4 (ATF4) and subsequently reduced the expression of the downstream genes xCT (solute carrier family 7a member 11, SLC7A11) and Cystathionine gamma-lyase (CTH) which play vital roles in GSH biosynthesis. Interestingly, the cytotoxic effects of SA were effectively attenuated by ATF4 overexpression, while they were significantly aggravated by ATF4 silencing. …”
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Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

“…Additionally, we observed substantial enrichment of immune-related proteins, reflecting high levels of cytotoxic T lymphocyte infiltration and elevated PD-1 expression. …”
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Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell by Nurhayati A.P.D., Fatoni M., Santoso M., Wati F.A.

“…Trisindoline is an indole trimer alkaloid natural compound that provide a cytotoxic effect on cancer cells. In 2021, modification of trisindoline has been synthesized into trisindoline 5. …”
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Mycosynthesis of zinc sulfide/zinc oxide nanocomposite using Fusarium oxysporum for catalytic degradation of methylene blue dye, antimicrobial, and anticancer activities by Hosam Salaheldin, Aya Aboelnga, Ashraf Elsayed

“…The ZnO/ZnS nanocomposite has a dose-dependent cytotoxic effect on breast cancer cells, with an IC50 of 197 ± 0.895 µg/mL. …”
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Allografting for Bosutinib, Imatinib, Nilotinib, Dasatinib, and Interferon Resistant Chronic Myeloid Leukemia without ABL Kinase Mutation by B. Uz, O. Bektas, E. Eliacik, H. Goker, Y. Erbilgin, M. Sayitoglu, N. Sayinalp, S. Aksu, Y. Buyukasik, O. Ozcebe, I. C. Haznedaroglu

“…The aim of this paper is to report a patient with complicated CML resistant to treatment and progressed despite the administration of bosutinib, imatinib mesylate, nilotinib, dasatinib, interferon alpha 2a, cytotoxic chemotherapy, and allogeneic hematopoietic stem cell transplantation. …”
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Immunomodulatory effect of efferocytosis at the maternal–fetal interface by Hui Tao, Ruilin Ma, Jianjian Cui, Zejun Yang, Wencong He, Yanan Li, Yin Zhao

“…Abstract Efferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trigger strong immune and inflammatory responses. …”
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Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review by Joanna Pogorzelska-Dyrbuś, Jacek C. Szepietowski

“…Moreover, there is evidence that LCs are probably capable of inducing the local cytotoxic type T-cell-mediated response against the tumour-associated antigens. …”
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Bone Formation from Porcine Dental Germ Stem Cells on Surface Modified Polybutylene Succinate Scaffolds by Nergis Abay, Gorke Gurel Pekozer, Mustafa Ramazanoglu, Gamze Torun Kose

“…For this study, MTS assay was used to assess the cytotoxic effects of modified and unmodified surfaces. …”
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Evaluation of the genotoxic and transformation potential induced by asbestos compared to cleavage fragments by Sebastiano La Maestra, Gaia M. Militello, Stefano Alberti, Mirko Benvenuti, Laura Gaggero

“…The results showed that exposure of alveolar lung cells to asbestos and elongated mineral particles, in the habit of cleavage fragments (CF) derived from the grinding of non-asbestiform amphiboles and serpentines, causes cytotoxic effects, oxidative stress and genotoxic damage. …”
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Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats by V. Gayathri, S. Ananthi, Hannah R. Vasanthi

“…In the present study, we have evaluated the toxicity profile of the 50% hydroethanolic extracts of Nerium oleander flowers (ENO) using in vitro brine shrimp lethality assay and MTT cytotoxicity assay and in vivo acute toxicity test as per the OECD guidelines. …”
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Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells by Germán Alvarado Tenorio, Roberto Espinosa Neira, Carlos Alberto Ávila Orta, Gabriela Yolotzín Romero Zúñiga, Hortensia Ortega Ortiz

“…The XRD characterization did not show noticeable differences in the crystallinity index (CI) for CSNPs and CSNPs-I, 48.4 and 49.3%, respectively, but for CSNPs-IO3, the CI decreased to 43.85%. The cytotoxic effects on human tumor cells of chitosan and iodine-modified chitosan nanoparticles (CSNPs-I and CSNPs-IO3) were evaluated for 24 h in a range from 0.15 mg/mL to 0.95 mg/mL concentrations, where CSNPs-IO3 presented the lower viability for lung cancer A549, followed by cervical cancer HeLa cell and finally breast cancer MDA-MB-231, with a weight content of iodate ion in a range of 8.7 to 15 μg. …”
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RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection. by Molly Huang, Adam Mark, Jessica Pham, Karina Vera, Amanda M Saravia-Butler, Afshin Beheshti, Qingfei Jiang, Kathleen M Fisch

“…Single cell RNA-sequencing analysis of SARS-CoV-2 infected nasopharyngeal swabs reveals that cytotoxic CD8 T cells upregulate ADAR1 in COVID-19 positive samples (p = 0.0269). …”
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Cilostazol protective effect on nedaplatin-induced genotoxicity in cultured human lymphocytes by Karem H. Alzoubi, Abeer M. Rababa’h, Omar F. Khabour, Fian Nuseir

“…Both the mitotic and proliferative indices (MI and PI, respectively) were used to assess the cytotoxic effects of nedaplatin. Results: Nedaplatin significantly increased the frequency of SCEs compared to control and cilostazol-treated cells. …”
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Role of cytokines and nitric oxide in the induction of tuberculostatic macrophage functions by Vera L. Petricevich, Rosely C. B. Alves

“…The amount of bacilli proportionally decreased with IFN-γ and TNF, suggesting a cytokine-related cytotox ic effect. Moreover, NO also decreased the viable number of bacilli. …”
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Ways to promote the efficiency of herpetic stomatitis treatment by R.V. Lutsenko, N.V. Moisieieva, A.H. Sydorenko, H.Yu. Ostrovska, A.A. Kapustianska

“…The drug suppresses the synthesis of the virus due to the structure of inosinic acid in the polyribosomes of the cell affected by the virus, and also helps to eliminate the deficiency or dysfunction of immunity that occurred in the case of herpetic stomatitis, it affects the activity of T-cytotoxic lymphocytes and natural killers, enhances the action of neutrophil granulocytes, chemotaxis and phagocytosis of monocytes and macrophages, increases the synthesis of interleukins IL-1 and IL-2, affects the number of Ig G immunoglobulins. …”
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Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers by A.N.K.V. Sravani, John Thomas

“…Thus, there is a need for medications that are both highly effective and with low cytotoxic for modulating EMT transitions at ground level. …”
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