Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I by Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, Elizabeth Barbosa

“…<b>Background</b>: Incomptine A (<b>IA</b>) has been reported to have cytotoxic activity in non-Hodgkin lymphoma cancer cell lines and have effects on U-937 cells, including the induction of apoptosis, the production of reactive oxygen species, and the inhibition of glycolytic enzymes. …”
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Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments by Habib Ghaznavi, Mohammad Reza Hajinezhad, Zahra Hesari, Milad Shirvaliloo, Saman Sargazi, Sheida Shahraki, Eshagh Ali Saberi, Roghayeh Sheervalilou, Somayeh Jafarinejad

“…This study aims to synthesize zinc oxide nanoparticles and copper-doped zinc oxide nanoparticles to harness the combined cytotoxic and anticancer effects of them in vitro and in vivo studies. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Both 125I-HLX58 and 131I-HLX58-Der exhibited significant binding affinity for the CLDN18.2-positive cancer cell line. The cytotoxic effect of 131I-HLX58-Der was observed in the CLDN18.2-positive cell line, with an IC50 of 11.28 ng/mL. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Abstract In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). …”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…This review of the current literature highlights the potential of PPARγ agonists as novel therapeutic modalities in lung cancer, either as monotherapy or in combination with standard cytotoxic chemotherapy.…”
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Adverse Reactions Caused by Biomaterials Used in Dentistry by Marco Antonio Mesache Villagómez, María Daniela Morales Núñez, Gabriela Vaca Altamirano

“…The results presented in this research may alert dental professionals to the use of various materials that have been shown to have cytotoxic effects. The most biocompatible materials were: ProRoot, BioRoot-RCS, Bulk Flow, Optibond Solo Plus, Adhese Universal, Vita Enamic, Lava Ultimate, Vita AC-12, InSync, Poligrip Flavor Free Fixative Cream Ketac Molar, Ionofil Molar, Twinky Star. …”
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Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review by Sumeyya Akyol, Veli Ugurcu, Aynur Altuntas, Rukiye Hasgul, Ozlem Cakmak, Omer Akyol

“…Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. …”
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Mechanism(s) of Toxic Action of Zn2+ and Selenite: A Study on AS-30D Hepatoma Cells and Isolated Mitochondria by Elena A. Belyaeva, Nils-Erik L. Saris

“…High [mu]M concentrations of Zn2+ or selenite were strongly cytotoxic, killing the AS-30D cells by both apoptotic and necrotic ways. …”
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Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene by Artur Kasprzak, Agnieszka Żuchowska, Hidehiro Sakurai

“…This work provides the method how to focus the cytotoxic action of sumanene toward cancer cells using supramolecular assembly strategy, paving the way to the further exploration of biological properties of sumanene-containing supramolecular systems with bioactive features and applications of this buckybowl in general.…”
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Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide by Abdou Saad El-Tabl, Moshira Mohamed Abd El-Waheed, Mohammed Ahmed Wahba, Nahla Abd El-Halim Abou El-Fadl

“…The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).…”
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The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis by Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace

“…Furthermore, TLR9 also stimulates interferon-α (INF-α) secretion and increases cytotoxic activity of CD4+ T-cells towards coronary artery tunica media smooth muscle cells. …”
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An Osteolytic Metastasis of Humerus from an Asymptomatic Squamous Cell Carcinoma of Lung: A Rare Clinical Entity by Anirban Das, Sudipta Pandit, Sibes k. Das, Sumitra Basuthakur, Somnath Das

“…It is also unusual that an asymptomatic squamous cell carcinoma of lung presents with painful, soft tissue swelling with osteolytic metastasis of humerus which is reported in our case. Systemic cytotoxic chemotherapy, local palliative radiotherapy, adequate analgesia, and internal fixation of the affected long bone are different modalities of treatment in this advanced stage of disease. …”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by Patrícia S. de Araújo-Souza, Steffi C. H. Hanschke, João P. B. Viola

“…However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. …”
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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…At the early stages of ADs, the repertoire of Abzs is usually relatively narrow, but it greatly expands with the progress of the disease, leading to the generation of catalytically diverse Abzs with different activities and functions. Some Abzs are cytotoxic and can play an important negative role in the pathogenesis of ADs, while positive roles have been proposed for other Abzs. …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…In the present study, we have used chlorogenic acid complex (CGA7) a decaffeinated water soluble green coffee bean extract to evaluate its cytotoxic effect on human and mouse cancer cell lines by using different approaches. …”
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer by Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin

“…Using TLR ligands as adjuvants induces upregulation of costimulatory signals which in turn activates a cytotoxic leukocyte response against cancer cells. …”
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Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles by Giada Santin, Luigi Scietti, Paola Veneroni, Sergio Barni, Graziella Bernocchi, Maria Grazia Bottone

“…Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. …”
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Cellular Senescence as a Target in Cancer Control by Mar Vergel, Juan J. Marin, Purificacion Estevez, Amancio Carnero

“…Cells displaying characteristics of senescent cells can also be observed in response to other stimuli, such as oncogenic stress, DNA damage, or cytotoxic drugs and have been reported to be found in vivo. …”
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Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells by A. Jiménez-Periáñez, B. Abos Gracia, J. López Relaño, C. M. Diez-Rivero, P. A. Reche, E. Martínez-Naves, E. Matveyeva, M. Gómez del Moral

“…The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.…”
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Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis by Pascal Lapierre, Alain Lamarre

“…In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. …”
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