ASSOCIATION BETWEEN PR PROTEINS WITH RIBONUCLEASE ACTIVITY AND PLANT RESISTANCE AGAINST PATHOGENIC FUNGI by E. A. Filipenko, A. V. Kochetov, Y. Kanayama, V. I. Malinovsky, V. K. Shumny

“…This paper presents current data on molecular mechanisms governing the antifungal activity of PR-ribonucleases connected both with their direct cytotoxic impact on pathogen cells and with possible participation in induction of plant cell apoptosis and development of the hypersensitive reaction (HR).…”
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Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities by Ngoc Hung Truong, Thi Hong Ha Tran, Kim Chi Hoang, Duc Bao Ninh, Viet Duc Le, Duc Anh Le, Van Chinh Luu

“…Screening in vitro biological activities revealed that most of the synthesized conjugates showed good cytotoxic and anti-inflammatory activity, while three of them displayed α-glucosidase inhibitory activity. …”
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TiO2 – do we have to worry about it? One of the important aetiological factors in inflammatory bowel disease by Sara Jarmakiewicz-Czaja, Aneta Sokal, Jacek Tabarkiewicz, Rafał Filip

“…It may have pro-inflammatory, cytotoxic, and genotoxic effects. A change in the composition of the host’s intestinal microflora is also observed after exposure to high doses of TiO2. …”
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Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection by Ali Vural, John H. Kehrl

“…Innate immune responses include the rapid induction of transcriptional networks that trigger the production of cytokines, chemokines, and cytotoxic molecules; the mobilization of cells including neutrophils and other leukocytes; the engulfment of pathogens by phagocytosis and their delivery to lysosome for degradation; and the induction of autophagy. …”
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Quercetin nanoparticles as a therapeutic approach: pharmacological actions and potential applications in therapy by Reham Farouk El-Sayed Baiomy

“…Furthermore, these nanoparticles have been scientifically documented to possess antioxidant, anticarcinogenic, hepatoprotective, and cytotoxic activities. This comprehensive review aims to explore the pharmacokinetics and biological activities associated with quercetin nanoparticles. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. …”
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Conventional Medicinal Uses, Phytoconstituents, and Biological Activities of Euphorbia officinarum L.: A Systematic Review by Imane Chamkhi, Mohamed Hnini, Jamal Aurag

“…Plants in the genus Euphorbia are well known for the chemical diversity of their diterpenoids and isoprenoid constituents, which perform many activities such as cytotoxic, antimicrobial, and anti-inflammatory activities, as well as different biological properties, that cannot be overlooked. …”
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Treatment of Decompensated Alcoholic Liver Disease by John Menachery, Ajay Duseja

“…The rationale for using glucocorticoids is to block cytotoxic and inflammatory pathways in patients with severe alcoholic hepatitis. …”
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Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants by Emily E. Miller, Leigh Christopher Reardon

“…Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. …”
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Effects of Various Flavonoids on the α-Synuclein Fibrillation Process by Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

“…Currently, there is no approved therapeutic agent directed toward preventing the protein aggregation, which has been recently shown to have a key role in the cytotoxic nature of amyloidogenic proteins. Flavonoids, known as plant pigments, belong to a broad family of polyphenolic compounds. …”
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Lepidium meyenii biological activity and future perspectives by Zoya Dzhakova, Diana Karcheva-Bahchevanska, Stanislava Ivanova

“…The main compounds in the underground part of the plant are glucosinolates, thiohydantoins, isothiocyanates, macamides, macaene, fatty acids, polysaccharides, alkaloids, fiber, lipids and proteins, which are responsible for various biological activities including antimicrobial, antioxidant, cytotoxic, anti-inflammatory and immunomodulatory activities. …”
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A Review on Current Knowledge of Medicinal Properties of Garcinia quaesita by Sivasinthujah Srikokulan, A. S. Nirubini

“…It provides information on its botanical descriptions, phyto-constituents, antioxidant, antibacterial, anti-hyperglycemic, anti-inflammatory, cytotoxic and anticancer activities. There have been few studies that reported the medicinal properties of the leaf, fruit rind and fruit. …”
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…In particular, whether they could cause an exacerbated cytotoxic response in susceptible tissues due to damage or disease, such as the heart, liver, spleen, or kidneys. …”
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Efficient One-Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials by Katarzyna Sidoryk, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Marek Kubiszewski, Marcin Cybulski, Jerzy Gubernator, Agnieszka Zagórska, Anna Jaromin

“…The compounds have been evaluated against chloroquine-sensitive and chloroquine-resistant P. falciparum strains. Their cytotoxicity to normal human dermal fibroblasts and their propensity to induce hemolysis have been also determined. …”
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5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell by Senthil Kumar Chinnaiyan, Agnes Mary Soloman, Ramesh Kannan Perumal, Arun Gopinath, Madhan Balaraman

“…In this study, 5‐FU‐G‐AuNPs exhibited potential cytotoxic and apoptotic effects on (MiaPaCa‐2) cell line.…”
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T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer by A. E. Albers, L. Strauss, T. Liao, T. K. Hoffmann, A. M. Kaufmann

“…Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression. …”
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The Effects of TLR Activation on T-Cell Development and Differentiation by Bo Jin, Tao Sun, Xiao-Hong Yu, Ying-Xiang Yang, Anthony E. T. Yeo

“…T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes. …”
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Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker by K. Earlam, C. A. Souza, R. Glikstein, M. M. Gomes, S. Pakhalé

“…Treatment includes smoking cessation and the potential use of glucocorticoids or cytotoxic agents depending on the severity of disease and multisystem involvement.…”
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Primary T-Cell Non-Hodgkin Lymphoma of the Vagina by J. L. Herraiz, A. Llueca, Y. Maazouzi, D. Piquer, A. Palmeiro, E. Calpe

“…The results of the immunohistological studies of the mass revealed the presence of a cytotoxic T-cell non-Hodgkin lymphoma, which is the least common subtype.…”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. …”
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