Pharmacological activities and phytochemical evaluation of coconut crude oil and upon exposure to ozone by Mohammed S. Almuhayawi, Mohammed H. Alruhaili, Muyassar K. Tarabulsi, Soad K. Al Jaouni, Abdulmajeed A. Alqurashi, Faisal A. Alraddadi, Duaa A. Bukhari, Hibah M. Albasri, Moayad S. Waznah, Samy Selim

“…A notable elevation of anti-Alzheimer impact was evident upon exposing coconut oil to ozone. Besides, the cytotoxic impact towards A-431 cells was slightly increased after exposing the oil to ozone. …”
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The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes by Yanru Ren, Said Alkildani, Kim Burckhardt, Alexander Köwitsch, Milena Radenkovic, Sanja Stojanovic, Sanja Stojanovic, Stevo Najman, Stevo Najman, Ole Jung, Luo Liu, Mike Barbeck, Mike Barbeck

“…The initial in vitro cytotoxic analyses revealed that the PC, EC, and HMDI crosslinked membranes were cytocompatible, while the GA crosslinked membrane was cytotoxic and thus selected as positive control in the further in vivo study. …”
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Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats by Doreen Enyang, Mubo A. Sonibare, Armelle D. Tchamgoue, Lauve R. Y. Tchokouaha, Fanta S. Yadang, Gael N. Nfor, Christelle W. Kom, Patrick D. H. Betote, Cedric F. Tchinda, Steveng S. K. Tiogo, Gabriel A. Agbor

“…PNS possessed in vitro cytotoxic, antioxidant, and anti-inflammatory activities. …”
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Nanoliposomal L-Asparaginase and Its Antitumor Activities in Lewis Lung Carcinoma Tumor-Induced BALB/c Mice by Thi Thao Do, Thi Phuong Do, Thi Nga Nguyen, Thi Cuc Nguyen, Thi Thu Phuong Vu, Thi Giang An Nguyen

“…The enzyme was then loaded into liposomes using the hydrated thin-film method. The in vitro cytotoxic activity of liposomal L-ASP was evaluated with the MTT assay using cancerous cell lines, and its antitumor effects were examined in Lewis lung carcinoma (LLC) tumorized mice. …”
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DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…ABSTRACT A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8+ T-cells that target conserved viral proteins and can eliminate infected cells to control virus spread. mRNA technology offers an opportunity to design vaccines based on conserved CD8-targeting epitopes, but achieving robust antigen-specific CD8+ T-cells remains a challenge. …”
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Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…In-vitro spheroid assay was performed to explored the PJLME-AF cytotoxic effects on tumour spheroid forming ability of melanoma cells. …”
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Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro by Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, Malgorzata Kucinska

“…It was shown that compound <b>2a</b> exerted a more potent cytotoxic effect under hypoxic conditions, while compound <b>2a-B</b> demonstrated a comparable effect in normoxic and hypoxic conditions. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Most importantly, Clo administration dramatically increased the cytotoxic activity of CD8+ T cells in vitro and in vivo. …”
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Successful Treatment of Disseminated Subcutaneous Panniculitis-Like T-Cell Lymphoma with Single Agent Oral Cyclosporine as a First Line Therapy by Nida Iqbal, Vinod Raina

“…Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare cutaneous neoplasm of mature cytotoxic T-cells. Currently there are no standardized therapies for SPTL; however good responses have been seen with chemotherapy regimens generally employed for B-cell lymphomas. …”
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Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata by Taisuke Ito

“…Alopecia areata is considered to be a cell-mediated autoimmune disease, in which autoreactive cytotoxic T cells recognize melanocyte-associated proteins such as tyrosinase. …”
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A Rare Case of Cyclophosphamide-Induced Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-GBM Vasculitis, and Review of Current Literature by Taha Nisar, Abdul R. Alchaki, Erin Feinstein

“…Precipitating factors for PRES are multifactorial and include autoregulatory failure due to changes in blood pressure, metabolic derangements, and cytotoxic medications. We report the second case of cyclophosphamide-induced PRES in a patient with anti-glomerular basement membrane (Anti-GBM) positive vasculitis. …”
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Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles by Heike E. Daldrup-Link MD, PhD

“…If successfully translated to clinical applications, the TNPs might hold substantial potential to improving cytotoxic indexes and long-term outcomes of patients with brain cancer compared to standard therapy.…”
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Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy by Qi Yan, Hemn Mohammadpour

“…They showed that inhibiting PAF signaling reduces MDSC‐mediated immunosuppression, thereby enhancing cytotoxic T‐cell activity. This approach may improve cancer immunotherapy outcomes, particularly when combined with checkpoint blockade therapies, suggesting a promising avenue for therapeutic development.…”
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Modeling of chemo-radiotherapy targeting growing vascular tumors: A continuum-level approach. by Ioannis Lampropoulos, Marina Koutsi, Michail E Kavousanakis

“…To enhance the therapeutic efficiency of radiotherapy, we investigate the combination of external radiation with the anti-VEGF drug bevacizumab and the cytotoxic drug docetaxel. Our simulations demonstrate that this synergistic approach integrates the immediate effectiveness of radiation therapy with the enduring tumor-suppressive capabilities of chemotherapy.…”
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Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy by Y. Maor, S. Malnick

“…Cytotoxic chemotherapy prolongs survival of patients with advanced and metastatic tumors. …”
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Dynamics of stochastic mutation to immunodominance by Yu Wu, Xiaopeng Zhao, Mingjun Zhang

“…Although a virus contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), the immune responses against different epitopes are not uniform. …”
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Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies by Luciano Potena, Andrea Bontadini, Sandra Iannelli, Fiorenza Fruet, Ornella Leone, Francesco Barberini, Laura Borgese, Valentina Manfredini, Marco Masetti, Gaia Magnani, Francesco Fallani, Francesco Grigioni, Angelo Branzi

“…By an inexpensive, luminex-based, HLA-screening assay, we were able to detect non-cytotoxic HLA ab predicting fatal and nonfatal adverse outcomes after heart transplant. …”
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Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockers by Ping Li, Zhen Qin, Yang Lu, Jiamin Gao, Zhenwei Wang, Ge Zhang, Han Yang, Yachen Hou, Dashuai Wang, Pengchong Du, Yunzhe Wang, Quanzhou Chen, Zhaowei Sun, Jinying Zhang, Junnan Tang

“…Single-cell RNA sequencing elucidated that MCC950 treatment reduced the cardiac infiltration of pathogenic macrophages, cytotoxic T cells, activated T cells, and their production of inflammatory cytokines, while enhancing the presence of reparative macrophages and naive T cells. …”
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Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening by Dan Zhao, Ravindra Deshpande, Kerui Wu, Abhishek Tyagi, Sambad Sharma, Shih-Ying Wu, Fei Xing, Stacey O'Neill, Jimmy Ruiz, Feng Lyu, Kounosuke Watabe

“…We integrated our results with multi-omics clinical data and performed both in vitro and in vivo assays to evaluate the role of the top candidate in regulating cytotoxic T cell killing. We identified TUBB3 as a potential target to overcome the resistance and enhance the efficacy of anti-PD-1 immunotherapy. …”
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Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid by Mouzoura P, Marazioti A, Gkartziou F, Metsiou DN, Antimisiaris SG

“…FTY720 demonstrated the ability to increase cell proliferation at 10– 300nM doses but was cytotoxic at doses> 400nM while the corresponding liposomal-FTY720 doses were non-cytotoxic, proving its reduced toxicity. …”
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