Dual-drug loaded chondroitin sulfate embolization beads enhance TACE therapy for HCC by integrating embolization, chemotherapy, and anti-angiogenesis by Jin-Xin Huang, Rui Yang, Huan Long, Jie Kong, Guo-Qiang Shao, Fei Xiong

“…We have developed chondroitin sulfate microspheres (CMs) capable of encapsulating both the cytotoxic drug idarubicin (Ida) and the vascular inhibitor Lenvatinib (Len), thereby achieving a triple therapeutic effect on liver cancer: embolic starvation, drug toxicity, and efficient inhibition of neovascularization.…”
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Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes by S. B. Cheknev, Y. G. Ashmanova, A. D. Pritsker, O. L. Latysheva, F. I. Yershov, A. J. Kulberg

“…The NK activity of PBL was detected by a cytotoxic test using 3H-uridine human erythromyeloblast K562 cells. …”
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Cellulose nanofiber reinforced curcumin-infused calcium phosphate silicate cement for various bone-tissue engineering application by Xiu Guo Lu, Xiu Guo Lu, Sha Li Meng, Sha Li Meng, Qiu Jing Zhou, Qiu Jing Zhou, Tao Wu, Tao Wu, Xing Tian Gong, Qiong Wu

“…IntroductionThis study utilized a injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC) for addressing defects caused by bone cancer, and evaluated its promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells.MethodsThe material’s physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity toward osteosarcoma cells were rigorously analyzed.ResultsThe findings demonstrate that CPSC-Cur signicantly prolongs the setting time, which can be optimized by adding silanized cellulose nanober (CNF-SH) to achieve a balance between workability and mechanical strength. …”
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Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection by O. Franzese, A. Mascali, A. Capria, V. Castagnola, L. Paganizza, N. Di Daniele

“…The immune reaction directed against a renal allograft has been suggested to be characterized by two major components: a destructive one, mediated by CD4+ helper and CD8+ cytotoxic T cells, and a protective response, mediated by Tregs. …”
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Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential. by Maryam Al Kaabi, Nancy A ElNaker, Nila Jan, Michael A Ochsenkühn, Shady A Amin, Lina F Yousef, Ahmed F Yousef

“…Results suggest that: 1) MAE is more efficient than maceration in recovering metabolites from plant biomass based on measurements of total phenolic content, radical scavenging activity, and bioactivity of extracts based on in vitro cytotoxicity. 2) Only T. nilotica extracts were found to be bioactive based on cytotoxicity measurements. 3) Cancer cell lines displayed differential sensitivity to T. nilotica crude extracts, with breast cancer cells being the most sensitive and lung cancer cells being the least sensitive. 4) Solid-phase fractionation of T. nilotica crude extract using different percentages of methanol resulted in several fractions that were 100-fold more cytotoxic compared to the crude unfractionated extract. …”
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Phytochemical Constituents and Biological Activities of Jasonia glutinosa L.: The First Report for the Plant Growing in North Africa by Hamdoon A. Mohammed, Abdulnaser Kh. Abdulkarim, Abdullah D. Alamami, Fatma A. Elshibani

“…The current study is the first report for the plant species growing in Libya and aims to investigate the phytochemical constituents, antioxidant, cytotoxic, and antimicrobial activities of the plant’s aqueous ethanolic extract. …”
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Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia by Amal F. Alshammary, Ghada BinSaif, Imran Ali Khan

“…The Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene has been reported to be related to vitiligo and other autoimmune diseases. …”
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Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics by Peter S. Kim, Joseph J. Crivelli, Il-Kyu Choi, Chae-Ok Yun, Joanna R. Wares

“…We found that the model closely matches previously published data, and while viral oncolysis is fundamental in reducing tumor burden, increased stimulation of cytotoxic T cells leads to a short-term reduction in tumor size, but a faster relapse. …”
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Molecular and cellular aspects of the impact of secondary metabolites from common barberry and hybrid goat’s rue on the HeLa cell line by E. Yu. Zlatnik, Ya. S. Enin, O. N. Burov, E. S. Bondarenko, A. B. Sagakyants, D. S. Kutilin, Yu. V. Dzigunova, O. G. Ishonina, E. V. Shalashnaya, N. D. Ushakova

“….), as well as to conduct a model experiment and molecular genetic study to evaluate their cytotoxic effect in vitro on the HeLa cell line.Materials and methods. …”
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Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells by Wei Liu, Yi Yu, Yi He, Meihong Lv

“…Conclusions lidocaine was cytotoxic to Hep-2 cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. …”
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Design of a Multiepitope Pan-Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach by Ella Mae Joy S. Sira, Lauren Emily Fajardo, Edward C. Banico, Nyzar Mabeth O. Odchimar, Fredmoore L. Orosco

“…Various bioinformatics tools were employed to predict epitopes for cytotoxic T lymphocytes, helper T lymphocytes, and B lymphocytes. …”
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Preparation and Antibacterial Activity of Some New 4-(2-Heterylidenehydrazinyl)-7-chloroquinoline Derivatives by Trong Duc Le, Ngoc Nam Pham, Tien Cong Nguyen

“…Additionally, all of the synthesized hydrazones were evaluated in terms of cytotoxic activity against four strains of bacteria and four strains of fungus at several concentrations of substrates. …”
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T Cell Repertoire and Inflammatory Bowel Disease by Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada

“…In fact, the authors have shown there is a selective decrease in the cytotoxic function of peripheral variable β8 T cells in Crohn’s disease. …”
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Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones by Vu Van Vu, Trinh Thi Nhung, Nguyen Thi Thanh, Luu Van Chinh, Vu Dinh Tien, Vu Thu Thuy, Do Thi Thao, Nguyen Hai Nam, Angela Koeckritz, Tran Khac Vu

“…Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. …”
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Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells by Alaleh Rezalotfi, Ghasem Solgi, Marzieh Ebrahimi

“…Interestingly, immune cells induced by gastrospheres showed significant cytotoxicity in terms of producing IFN-γ and death induction in target cells. …”
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Long-Term GAD-alum Treatment Effect on Different T-Cell Subpopulations in Healthy Children Positive for Multiple Beta Cell Autoantibodies by Falastin Salami, Lampros Spiliopoulos, Marlena Maziarz, Markus Lundgren, Charlotte Brundin, Rasmus Bennet, Magnus Hillman, Carina Törn, Helena Elding Larsson

“…GAD-alum-treated children had lower levels of lymphocytes (109 cells/L) (p=0.006), T-cells (103 cells/μL) (p=0.008), T-helper cells (103 cells/μL) (p=0.014), and cytotoxic T-cells (103 cells/μL) (p=0.023) compared to the placebo-treated children 18 months from first GAD-alum injection. …”
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Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures by Mariana Nunes, Sara Ricardo

“…Conclusions: Combining Paclitaxel with Ivermectin has the highest cytotoxic and the strongest additive effect for both chemoresistant cell lines compared to Paclitaxel alone.…”
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Isolation and Identification of Endophytic Fungi from Syzygium cumini Linn and Investigation of Their Pharmacological Activities by Mst. Mabiya Sultana Samapti, Farhana Afroz, Satyajit Roy Rony, Suriya Sharmin, Fatema Moni, Shammi Akhter, Sheikh Feroz Uddin Ahmed, Md. Hossain Sohrab

“…Some fungal extracts showed cytotoxic activity that, in general, suggests their probable abundance of biological metabolites. …”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. by Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

“…Because these mutations confer resistance to commonly used cytotoxic chemotherapies and targeted agents, effective therapies that target K-Ras are needed. …”
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Anticancer Potential of Fruit Extracts from Vatica diospyroides Symington Type SS and Their Effect on Program Cell Death of Cervical Cancer Cell Lines by Atchara Chothiphirat, Kesara Nittayaboon, Kanyanatt Kanokwiroon, Theera Srisawat, Raphatphorn Navakanitworakul

“…The results suggest that ACE has potent and selective cytotoxic effect against cervical cancer cells and the potential to induce bax and caspase-8-dependent apoptosis. …”
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