Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…Next, we measured the cytotoxic effects of the media conditioned by pEL1-transfected HEK293T cells, as assayed against the panel of three human cancer cell lines: MDA-MB-231 (adenocarcinoma), PC3 (prostate cancer), and T98G (glioblastoma). …”
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Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA) by Ebtesam S. Al-Sheddi, Nida N. Farshori, Mai M. Al-Oqail, Shaza M. Al-Massarani, Quaiser Saquib, Rizwan Wahab, Javed Musarrat, Abdulaziz A. Al-Khedhairy, Maqsood A. Siddiqui

“…The cytotoxic response observed was in a concentration-dependent manner. …”
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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors by Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield

“…Abstract Antibody-drug conjugates (ADCs) are increasingly used in clinic for multiple indications and may improve upon the activity of parental antibodies by delivering cytotoxic payloads into target cells. This activity is predicated upon internalization to release the cytotoxic payloads intracellularly. …”
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Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents by Ghorab Mostafa M., Bashandy Mahmoud S., Alsaid Mansour S.

“…Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. …”
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Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy by Maha Gamal, Zainab Abdel Wahab, Mohamed Eshra, Laila Rashed, Nivin Sharawy

“…The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone. …”
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Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants by Zhongjie Sun, Zhongyan Wu, Xuncheng Su

“…Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells. …”
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Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma by Shinichi Harada, Keiki Nagaharu, Youichirou Baba, Tetsuya Murata, Toshiro Mizuno, Keiki Kawakami

“…In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. …”
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Novel 4-aminoquinazoline derivatives as new leads for anticancer drug discovery by Ghorab Mostafa M., Alsaid Mansour S.

“…All the newly synthesized compounds were evaluated for in vitro cytotoxic activity against the breast cancer cell line MCF-7. …”
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Nitric oxide modulates interleukin-2-induced proliferation in CTLL-2 cells by J. Padrón, L. Glaría, O. Martinez, M. Torres, E. Lopez, R. Delgado, L. Caveda, A. Rojas

“…These findings prompted us to suggest that intra- and/or inter-cellular nitric oxide signalling may contribute to the modulation of the IL2 mitogenic effect upon cytotoxic T lymphocytes.…”
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Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death by Roberta Palorini, Tiziana Simonetto, Claudia Cirulli, Ferdinando Chiaradonna

“…In particular, our results reveal that low doses of Complex I inhibitors, ineffective on immortalized cells and in high glucose growth, become specifically cytotoxic on cancer cells deprived of glucose. Importantly, the cytotoxic effect of the inhibitors on cancer cells is strongly enhanced by forskolin, a PKA pathway activator, that we have previously shown to stimulate OXPHOS. …”
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Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice by Sahdeo Prasad, Smita Srivastava, Madhulika Singh, Yogeshwer Shukla

“…The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow.…”
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Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mi... by Temitayo Aiyelabola, Ezekiel Akinkunmi, Efere Obuotor, Idowu Olawuni, David Isabirye, Johan Jordaan

“…The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.…”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

“…Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy) can accumulate at clearance organs like kidneys and liver, where they can cause dose-limiting toxicities. …”
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A Mathematical Model for the Within-Host Dynamics of Malaria Parasite with Adaptive Immune Responses by Jemal Muhammed Ahmed, Getachew Tashome Tilahun, Shambel Tadesse Degefa

“…The model includes six compartments, namely, the uninfected red blood cells, infected red blood cells, merozoites, gametocytes, cytotoxic T cells immune response, and antibodies immune response, which are activated in the host to attack the parasite. …”
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Precise Construction of Dual-Promising Anticancer Drugs Associated with Gold Nanomaterials on Glioma Cancer Cells by P. Baby Shakila, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Samer Hasan Hussein-Al-Ali, Beza Mulugeta

“…When taken combined, cabazitaxel (CTX) and cisplatin (PT) have more excellent cytotoxic effects than drugs used alone in the chemotherapy of several different cancers. …”
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Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis by Georgiana-Iulia Lupu, Emoke Pall, Mihai Cenariu, Monica Irina Nan, Sanda Andrei

“…This study investigates the cytotoxic (MTT assay) and pro-apoptotic effects of metamizole and its primary metabolites, 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA), on the LX-2 liver cell line. …”
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Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells by Lu Han, Yi-Man Shang, Yong-Ping Song, Quan-Li Gao

“…There was no difference between OKT-CIK and R-CIK cells in cytotoxic ability against lymphoma cell line K562. …”
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Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells. by Napat Armartmuntree, Yingpinyapat Kittirat, Bundit Promraksa, Watcharin Loilome, Hasaya Dokduang, Anchalee Techasen, Pahol Sansomchai, Malinee Thanee, Thomas O'Connor, Phutthida Kongthitilerd, Sureerat Padthaisong

“…The cytotoxic effects of TC extracts on CCA cell lines (KKU-213A and KKU-213C) were evaluated using MTT assays and flow cytometry. …”
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Miliary Tuberculosis in Immunocompromised Patient Induced by Imatinib and Steroid by Randa Fermada, Fauzar Fauzar, Roza Kurniati, Irza Wahid

“…The use of steroid and cytotoxic drugs increases the incidence of miliary tuberculosis.  …”
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Evaluation of targeted therapy on the activity of curcumin and doxorubicin anticancer agents in breast cancer: A systematic literature review by Indriani Dwi Kartika, Dewi Salma Kumala, Az-zahra Mutiara, Siagian Dina Ariya, Alifatunnisa Nur Iqlima, Lolita Lolita, Novitasari Putri Rachma, Ittiqo Dzun Haryadi, Ikhsanudin Azis

“…The method used in searching for articles was using the Scopus database with the type of literature analyzed, namely research on the cytotoxic activity of curcumin and doxorubicin with key keywords (“Doxorubicin” OR “Curcumin” AND “Breast” AND “Cancer” AND “Therapy” AND “ Cytotoxicity”). …”
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