Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study. by Phoibe Renema, Jean-Francois Pittet, Angela P Brandon, Sixto M Leal, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T Lin, K Adam Morrow, Jessica Bell, Jonathon P Audia, Diego Alvarez, Troy Stevens, Brant M Wagener

“…Levels of tau and Aβ42 in, and cytotoxicity of, the bronchoalveolar lavage fluid were measured. …”
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High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity by Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu

“…However, the role of NK and iNKT cells expressing cytokines, cytotoxic, and immune markers in latent tuberculosis (LTB), diabetes mellitus (DM), or preDM (PDM) and nonDM (NDM) comorbidities is not known. …”
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Severe atopic dermatitis treated with Dupilumab in a CTLA-4-deficient patient: A case report and review of the literature by Ye-Jean Park, Jennifer Grossman, Lynne Robertson

“…Atopic dermatitis is a chronic inflammatory skin disease associated with immune dysregulation, particularly overexpression of T helper 2 cytokines. Cytotoxic T lymphocyte-associated antigen 4 deficiency, a primary immune disorder, can exacerbate atopic dermatitis. …”
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Anticancer and Antioxidant Activities of Methanolic Extract of Ziziphus Spina-Christi Leaves against Human Gastric Carcinoma Cells by Samir Abdulkarim Alharbi

“…The results show that Z. spina-christi extract possesses cytotoxic and antioxidant actions.…”
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Differential Toxicity of DNA Adducts of Mitomycin C by Jill Bargonetti, Elise Champeil, Maria Tomasz

“…DMC is more cytotoxic than MC and can also kill p53-deficient cells by inducing degradation of Checkpoint 1 protein, which is not seen with MC treatment of the p53-deficient cells. …”
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DNA Damage Induced by Alkylating Agents and Repair Pathways by Natsuko Kondo, Akihisa Takahashi, Koji Ono, Takeo Ohnishi

“…The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. …”
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Evaluating the Effect of Chloroform and Water Extract of Satureja khuzistanica on the Expression of Bcl-2 and Bax in Gastric Cancer Cell Line by Bagher Biglak, Asghar Tanomand, Leyla Açik, Farzad Arjomandi Rad, Gholamreza Shahsavari, Saman Kazemi, Hossein Soltanzadeh

“…In addition, extracts showed cytotoxic activity against gastric cancer cell lines. …”
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Micro-PET/CT Monitoring of Herpes Thymidine Kinase Suicide Gene Therapy in a Prostate Cancer Xenograft: The Advantage of a Cell-specific Transcriptional Targeting Approach by Mai Johnson, Makoto Sato, Jeremy Burton, Sanjiv S. Gambhir, Michael Carey, Lily Wu

“…Cancer gene therapy based on tissue-restricted expression of cytotoxic gene should achieve superior therapeutic index over an unrestricted method. …”
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Clinical advances in antibody-drug conjugates for hematological malignancies by TANG Sijie, MI Jianqing

“…The linkers are then cleaved via endosomal-lysosome pathway and the cytotoxic drug is released, which induces apoptosis in the target cells. …”
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Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite by G. Telegeev, N. Kutsevol, V. Chumachenko, A. Naumenko, P. Telegeeva, S. Filipchenko, Yu. Harahuts

“…The effect of nanosilver on cell viability was lower than the one of polymer/cisplatin composite. The data from the cytotoxic studies indicate that nanosilver induces toxicity in cells. …”
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Efficient and Convenient Route for the Synthesis of Some New Antipyrinyl Monoazo Dyes: Application to Polyester Fibers and Biological Evaluation by Ahmed A. Fadda, Khaled M. Elattar

“…The data showed clearly that most of the compounds exhibited good antioxidant and cytotoxic activities.…”
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Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro by Windy Aristiani, Widea Rossi Desvita, Dika Khayatulisma, Citra Ariani Edityaningrum, Any Guntarti, Laela Hayu Nurani

“…The investigation was initiated with cytotoxic and combination tests using the MTT method. …”
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Antiproliferative and genotoxic potential of xanthen-3-one derivatives by Veljović Elma, Špirtović-Halilović Selma, Muratović Samija, Osmanović Amar, Haverić Sanin, Haverić Anja, Hadžić Maida, Salihović Mirsada, Malenica Maja, Šapčanin Aida, Završnik Davorka

“…Compound with chlorine and fluorine substituents on aryl ring showed the best antiproliferative activity against SW620 with IC50 of 4.1 µmol L–1 and against HepG2 tumor cell line with IC50 of 4.2 µmol L–1. Analyses of cytotoxic and genotoxic potential of the trifluormethyl derivative were performed with cytokinesis-block micronucleus cytome assay in human lymphocyte culture and revealed no genotoxic and cytotoxic effects. …”
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Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors by Doaa A. Elsayed, Mohamed E. Abdu, Mohammed A. Marzouk, Elsayed M. Mahmoud, Walaa H. El-Shwiniy, Andrew M. Spring, Wesam S. Shehab

“…Specifically, when comparing the cytotoxic effects on human lung fibroblast (WI38) cells to those of Doxorubicin, a well-known chemotherapy agent, compounds 8, 15, and 17 showed weak cytotoxic effects on the normal WI38 cells. …”
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Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…The chronic effects of these cytotoxic actions could potentially lead to tissue damage or trauma, resulting in subsequent chronic inflammation.…”
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Optimal and suboptimal protocols for a mathematical model for tumor anti-angiogenesis in combination with chemotherapy by Urszula Ledzewicz, Helmut Maurer, Heinz Schättler

“…We consider the problem of minimizing the tumor volume with a priorigiven amounts of anti-angiogenic and cytotoxic agents. For oneunderlying mathematical model, optimal and suboptimal solutions aregiven for four versions of this problem: the case when onlyanti-angiogenic agents are administered, combination treatment witha cytotoxic agent, and when a standard linear pharmacokineticequation for the anti-angiogenic agent is added to each of thesemodels. …”
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PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium by Lucie Bienfait, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…Lymphoepithelioma-like carcinoma of the endometrium is a very rare variant of endometrial carcinoma characterized by syncytial nests of pleomorphic epithelial cells and heavy infiltration of the stroma by lymphocytes (in particular CD8 cytotoxic T-lymphocytes) and plasma cells. Until now, only five cases have been characterized in this location. …”
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Exploring Substituted Tetrazoloquinazoline: Biological Activities, Molecular Docking Analysis, and Anti-Breast Cancer MCF7/HER2 Effects by Neni Frimayanti, Ihsan Ikhtiarudin, Rahma Dona, Rahul Oktarizal, Aprilia Cindy Nurfatimah

“…Additionally, the physicochemical and pharmacokinetic properties of quinazoline compounds were assessed using the website https://www.swissadme.ch. The cytotoxic activity of the compounds was evaluated using the MTT assay. …”
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Recent advances of antibody-drug conjugates in treating breast cancer with different HER2 status by Yue Qiu, Yaqin Shi, Zhujun Chao, Xinyu Zhu, Yan Chen, Linlin Lu

“…ADCs combine the specificity of monoclonal antibodies with the cytotoxic effects of chemotherapy, which allows for the targeted delivery of a cytotoxic payload to cancer cells. …”
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Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy by Kahori Seto, Junichi Shoda, Tomohisa Horibe, Eiji Warabi, Masayuki Kohno, Toru Yanagawa, Hiroki Bukawa, Yasuni Nakanuma, Koji Kawakami

“…The IL-4Rα-lytic hybrid peptide showed cytotoxic activity in six BTC cell lines with a concentration that killed 50% of all cells (IC50) as low as 5 μM. …”
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