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    The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells by Chien-Ting Lin, Shang-Ju Wu, Cheng Hao Liao, Reyhung Roc Weng, Chun-Ming Lin

    Published 2025-12-01
    “…Moreover, combining eCD16A/anti-CD3-BFP with anti-Epstein Barr virus (EBV) antibodies directed T cell cytotoxicity toward EBV-infected cells. These findings support further development of eCD16A/anti-CD3-BFP as a novel anti-cancer therapeutic to stimulate both innate and adaptive immunity.…”
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    IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release by John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski, Yariv Mazor

    Published 2024-12-01
    “…A promising strategy is the use of peptide-major histocompatibility class I bispecific antibodies (pMHC-IgGs), which have emerged as an intriguing modality of TCE, based on their ability to selectively redirect highly reactive viral-specific effector memory cytotoxic CD8+ T cells to eliminate cancer cells. However, the relatively low frequency of these effector memory cells in human peripheral blood mononuclear cells (PBMCs) may hamper their redirection as effector cells for clinical applications. …”
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    Valorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibition by Adrián Millán-Laleona, Pilar Cebollada, Giovanni Caprioli, Diletta Piatti, Filippo Maggi, Ana Pina, Carlota Gómez-Rincón, Víctor López

    Published 2025-01-01
    “…Moreover, cellular viability was determined to perform MTT assay in HepG2 and HeLa cell lines to discard cytotoxicity. The results showed that procyanidin B2 (PB2), 3-caffeoylquinic acid, epicatechin and 4-hydroxy benzoic acid were the most abundant phenolic compounds. …”
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