miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

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Exploring northeast India’s culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance by Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum, Jagat Chandra Borah, Debajit Thakur

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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

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In vitro antiplasmodial activity of six plants against chloroquine-sensitive and resistant strains of Plasmodium falciparum by Samuel Korsah

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Delayed drug hypersensitivity reactions: How p-i transforms pharmacology into immunology by Werner J. Pichler

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Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy by Luis Daniel Goyzueta-Mamani, Daniela Pagliara Lage, Haruna Luz Barazorda-Ccahuana, Margot Paco-Chipana, Mayron Antonio Candia-Puma, Gonzalo Davila-Del-Carpio, Alexsandro Sobreira Galdino, Ricardo Andrez Machado-de-Avila, Rodolfo Cordeiro Giunchetti, Edward L. D’Antonio, Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli

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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

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Evaluation of Mechanochemically Prepared CePO₄∙H₂O Nanoparticles as UV Filter for Photoprotective Formulations by Stanislav Kurajica, Filip Brleković, Sabina Keser, Goran Dražić, Katarina Mužina, Vanesa Mihajlović

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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling by Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu, Jilei Li, Kedeerya Aishanjiang, Yujie Ma, Chang Yu, Bo Yu, Chunhong Cui, Hui Wang, Xianming Kong, Shibo Li, Xiaoni Kong, Ying Tong, Hailong Wu

“…Additionally, in vitro cytotoxic assays and patient-derived xenograft (PDX) models assessed the effects of circUCK2(2,3) on the cytotoxic synergy of lenvatinib and EGFR inhibitors. …”
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Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral Squamous Carcinoma (HSC-4) Cells by Witsanu Srila, Kritsana Sripilai, Thunwa Binlateh, Peungchaleoy Thammanichanon, Watcharaphol Tiskratok, Parinya Noisa, Paiboon Jitprasertwong

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Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver DiseasesSummary by Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang

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1H and 13C NMR Assignments of Cytotoxic 3S-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from the Leaves of Cichorium endivia by Fu-Xin Wang, An-Jun Deng, Jin-Feng Wei, Hai-Lin Qin, Ai-Ping Wang

“…The complete assignment of its 1H and 13C NMR spectroscopic data was carried out also for the first time based on extensive 1D and 2D NMR experiments. Cytotoxicity of this isolated compound against HCT-8 and HepG2 human cancer cell lines was evaluated for the first time, with moderate activities being found.…”
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Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes by Muhammad Jamil, Muhammad Zubair, Muhammad Asim Farid, Umer Rashid, Nasir Rasool, Saiful Islam

“…These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.…”
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Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1) by Dao Viet Hung, Tran Khac Vu

“…In this research, 4,7,9-trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide (13) derived from (–)-cercosporamide was synthesized via a seven-step procedure by well-known reactions and evaluation of cytotoxicity and inhibition of CaPkc1. The bioassay showed CaPkc1 inhibitory activity 87% higher and cytotoxicity 100 times less than the reference, (–)-cercosporamide.…”
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Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

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Characterization and evaluation of the cytotoxic, antioxidant, and anti-human lung cancer properties of copper nanoparticles green-synthesized by fennel extract following the PI3K/AKT/Mtor signaling pathway. by Tao Huang, KaiLi Ma, Yihua Wang

“…CuNPs caused cytotoxicity in a dose-dependent manner for two NSCLC cell lines, A549 and H1650. …”
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Peiminine Enhances Doxorubicin Cytotoxicity and Downregulates hsa-miR-106a-5p and hsa -miR-181a-5p in Human Gastric Adenocarcinoma Cells by Shirin Hedayati, Hossein Soltanzadeh, Hadi Esmaeili Gouvarchin Ghaleh, Zahra Hojjati Bonab, Akbar Ghorbani Alvanegh

“…This research aims to study the effects of Peiminine on Doxorubicin cytotoxicity and detect the expression levels of hsa-miR-106a-5p and hsa-miR-181a-5p in AGS human gastric adenocarcinoma cells. …”
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Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer by Fangze Wei, Xiaotian Xu, Jing Wang, Shi Wen Mei, Fu Qiang Zhao, Fei Huang, Ti Xian Xiao, Guo Jing Wang, Baojun Wei, Shengkai Huang, Wei Cui

“…The presence of CD8+ CXCR5+ follicular cytotoxic T (TFC) cells is strongly associated with autoimmune disease and CD8+ effector function. …”
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Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

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