Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole by L. Kyros, N. Kourkoumelis, M. Kubicki, L. Male, M. B. Hursthouse, I. I. Verginadis, E. Gouma, S. Karkabounas, K. Charalabopoulos, S. K. Hadjikakou

“…All these complexes and {[(Et3NH)+]2⋅[Ag6(μ3-Hmna)4(μ3-mna)2]2−⋅(DMSO)2⋅(H2O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity. The in vitro testing of cytotoxic activity of 1–5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays. …”
Get full text

Corrigendum to “Combinatorial Cytotoxic Effects of Gelam Honey and 5-Fluorouracil against Human Adenocarcinoma Colon Cancer HT-29 Cells In Vitro” by Syed Ahmad Tajudin T-Johari, Fatimah Hashim, Wan Iryani W. Ismail, Abdul Manaf Ali

Get full text

Cytotoxic and cytostatic activity of five new imidazotetrazine derivatives on breast cancer cell cultures MDAMB231, BT474, and MCF-7 by Ahmed Hamid Al-Humairi, Svetlana E. Sitnikova, Valery V Novochadov

Subjects: Get full text

Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15 by Syh-Jae Lin, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Wen-I Lee, Ji-Yih Chen, Jing-Long Huang

Get full text

Optimization of betulinic and ursolic acids and phenolics extraction from endemic Rosa pisiformis using Box-Behnken design in relation to cytotoxic activities by Hatice Demiray, Mesut Emir Dibek, Onur Özel

“…Betulinic acid content was determined for the first time in stems (hexane, 11.84 µg/ml) and roots (9.32 µg/ml). Their cytotoxic activities against prostate and lung carcinoma cells were evaluated using ABTS-assay, revealing that stems exhibited the highest activity, followed by leaves and roots.…”
Get full text

E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…Abstract Background Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro. …”
Get full text

Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content by Evellyne de Oliveira Figueirôa, Luís Cláudio Nascimento da Silva, Cristiane Moutinho Lagos de Melo, Juliana Kelle de Andrade Lemoine Neves, Nicácio Henrique da Silva, Valéria Rêgo Alves Pereira, Maria Tereza dos Santos Correia

“…This current study was designed to quantify the polyphenols and flavonoids contents and evaluate the immunomodulatory, antioxidant, and cytotoxic potentials of fractions from E. uniflora L. and E. malaccensis L. …”
Get full text

Chemical Composition and Cytotoxic and Antioxidant Activities of Satureja montana L.... by Hanene Miladi, Rihab Ben Slama, Donia Mili, Sami Zouari, Amina Bakhrouf, Emna Ammar

“…EO was investigated for its cytotoxic and antioxidant activities. The results revealed a significant cytotoxic effect of S. montana L. …”
Get full text

Thiazolo-pyridopyrimidines: An in silico evaluation as a lead for CDK4/6 inhibition, synthesis and cytotoxicity screening against breast cancer cell lines by Chaithra R Shetty, C. S. Shastry, Parasuraman P, Srinivas Hebbar

Subjects: Get full text

Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…In this study, we demonstrated that Elo pretreatment significantly enhanced CD16-independent NK cell-mediated cytotoxicity in both SLAMF7-positive MM.1S and SLAMF7-negative K562, U266, and RPMI 8226 tumor cells. …”
Get full text

Erratum: Effect of Andrographis paniculata Herbal Extract on Cytotoxicity, Proliferation and Osteogenic/Odontogenic Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study

Get full text

Evaluation of the Cytotoxicity of Aqueous Extract and Oleo-Essential Oil of Dorema ammoniacum Plant Oleo-Gum Resin in Some Human Cancer Cell Lines by Pardis Mohammadi Pour, Spideh Bidad, Gholamreza Bahrami, Leila Hosseinzadeh, Mahdi Mojarrab, Mohammad Hosein Farzaei

“…This study is aimed at examining the cytotoxic and apoptotic activity of the aqueous extract and essential oil of Dorema ammoniacum D. …”
Get full text

Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells by Jean Paul Dzoyem, Shashank Reddy Pinnapireddy, Hugues Fouotsa, Jana Brüßler, Frank Runkel, Udo Bakowsky

“…The cytotoxicity was assessed by the MTT assay. The fluorometric cyclooxygenase (COX) activity assay kit was used to assess the COX activity while the nitric oxide production was evaluated by the Griess reagent method. …”
Get full text

Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

Subjects: “…Multimodal, synergistic cytotoxicity…”
Get full text

Comparative Cytotoxic Activity of Wild Harvested Stems and In Vitro-Raised Protocorms of Dendrobium chryseum Rolfe in Human Cervical Carcinoma and Glioblastoma Cell Lines by Bijaya Pant, Pusp Raj Joshi, Sabitri Maharjan, Laxmi Sen Thakuri, Shreeti Pradhan, Sujit Shah, Sven H. Wagner, Basant Pant

“…Similarly, activities against U251 cell lines exhibited also significant inhibition (28.76% (612.54 μg/mL) for DCW and 17.15% (1059.92 μg/mL) for DCT). The cytotoxic activities of both, wild and tissue-cultured samples, were superior in HeLa cells. …”
Get full text

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile by Mohareb Rafat M., Abdallah Amira E. M., Ahmed Ebtsam A.

Subjects: Get full text

LC-MS profiling and cytotoxic activity of Angiopteris helferiana against HepG2 cell line: Molecular insight to investigate anticancer agent. by Bipindra Pandey, Shankar Thapa, Mahalakshmi Suresha Biradar, Bhoopendra Singh, Jaya Bahadur Ghale, Pramod Kharel, Prabhat Kumar Jha, Ram Kishor Yadav, Sujan Dawadi, Poojashree V

“…The extract showed the moderate cytotoxic activity having IC50 value of 236.93 μg/mL. …”
Get full text

Rectal application of a highly osmolar personal lubricant in a macaque model induces acute cytotoxicity but does not increase risk of SHIV infection. by Sundaram A Vishwanathan, Monica R Morris, Richard J Wolitski, Wei Luo, Charles E Rose, Dianna M Blau, Theodros Tsegaye, Sherif R Zaki, David A Garber, Leecresia T Jenkins, Tara C Henning, Dorothy L Patton, R Michael Hendry, Janet M McNicholl, Ellen N Kersh

“…We use a macaque model to evaluate rectal cytotoxicity and SHIV infection risk after use of a highly osmolar (>8,000 mOsm/kg) water-based lubricant with pH of 4.4, and containing PQ15.…”
Get full text

Synthesis of chitosan/PVA/copper oxide nanocomposite using Anacardium occidentale extract and evaluating its antioxidant, antibacterial, anti-inflammatory and cytotoxic activities by Manickam Rajkumar, S. I. Davis Presley, Prabha Govindaraj, Dharmalingam Kirubakaran, Farha Farahim, Talat Ali, Mohd Shkir, Sellapillai Latha

“…CS/PVA/CuONCs was shown to have strong cytotoxicity against MCF-7 cell lines. It also had the highest cell viability inhibition, at 13.66 ± 0.58%. …”
Get full text

Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies by Ahmad Ebadi, Aref Karimi, Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli

“…Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). …”
Get full text