A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential by M. P. Ponomarenko, I. V. Chadaeva, P. M. Ponomarenko, A. G. Bogomolov, D. Yu. Oshchepkov, E. B. Sharypova, V. V. Suslov, A. V. Osadchuk, L. V. Osadchuk, Yu. G. Matushkin

Get full text

Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

Get full text

Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…In turn, single nucleotide polymorphisms (SNPs) in human gene promoters can affect TBP affinity for DNA and, as a consequence, gene expression. The Institute of Cytology and Genetics SB RAS (ICG) has developed a method for predicting TBP affinity for gene promoters based on a three-step binding mechanism: (1) TBP slides along DNA, (2) TBP stops at the binding site, and (3) the TBP-promoter complex is fixed due to DNA helix bending. …”
Get full text

Collection of microorganisms of ICG SB RAS as a genetic resource for biotechnology by A. V. Bryanskaya, Y. E. Uvarova, A. S. Rozanov, N. M. Slynko, V. N. Shlyakhtun, K. V. Starostin, E. A. Demidov, E. V. Lazareva, O. P. Taran, S. E. Peltek

“…The aim of this work was to assess the key molecular-genetic and phenotypic characteristics of strains of the collection of microorganisms created in the “FRC Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences” as a genetic resource for biotechnology. …”
Get full text

Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior by A. O. Bragin, O. V. Saik, I. V. Chadaeva, P. S. Demenkov, A. L. Markel, Yu. L. Orlov, E. I.  Rogaev, I. N. Lavrik, V. A. Ivanisenko

Get full text

The expression profile of genes associated with behavior, stress, and adult neurogenesis along the hippocampal dorsoventral axis in tame and aggressive foxes by Yu. V. Alexandrovich, E. V. Antonov, S. G. Shikhevich, A. V. Kharlamova, L. V. Meister, Y. V. Makovka, D. V. Shepeleva, R. G. Gulevich, Yu. E. Herbeck

Get full text

Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

Get full text

Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice by S. O. Maslennikova, G. V. Kontsevaya, M. A. Zolotykh, M. V. Anisimova, N. A. Feofanova, M. P. Moshkin, S. A. Nedospasov, L. A. Gerlinskaya

Get full text

Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles by A. V. Romashchenko, D. V. Petrovskii, M. B.  Sharapova, Y. M. Moshkin, K. E. Kuper, K. N.  Morozova, E. V. Kiseleva, M. P. Moshkin

Get full text

Genome resource banking in the family Felidae by S. Ya. Amstislavsky, V. I. Mokrousova, V. V. Kozhevnikova, E. A. Kizilova, E. Yu. Brusentsev, K. A. Okotrub, V. A. Naprimerov, S. V. Naidenko

“…Genome Resource Bank (GRB) containing frozen semen of Amur leopard cat, bobcat and Eurasian lynx was established at the Institute of Cytology and Genetics, Novosibirsk. As a result of this project, original methods of feline semen freezing have been developed; embryos of domestic cat have been successfully frozen as well. …”
Get full text

DYNAMICS OF IL12 CYTOKINE EXPRESSION IN HUMAN MACROPHAGES AFTER TREATMENT WITH DIOXIN by D. Y. Oshchepkov, E. V. Kashina, E. V. Antontseva, E. A. Oshchepkova, V. A. Mordvinov, D. P. Furman

Get full text

COMPUTERIZED ANALYSIS OF THE RELATIONSHIP BETWEEN ALLERGENICITY OF MICROORGANISMS AND THEIR HABITATS by A. O. Bragin, P. S. Demenkov, E. S. Tiys, R. Hofestädt, V. A. Ivanisenko, N. A. Kolchanov

Get full text

Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

Get full text

Effects of neonatal handling on behavior and stress-response in rats selected for reaction towards humans by Yu. E. Herbeck, O. A. Amelkina, M. Yu. Konoshenko, S. G. Shikhevich, R. G. Gulevich, R. V. Kozhemyakina, I. Z. Plyusnina, I. N. Oskina

Get full text

A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells by V. S. Ruzanova, S. G. Oshikhmina, A. S. Proskurina, G. S. Ritter, S. S. Kirikovich, E. V. Levites, Y. R. Efremov, T. V. Karamysheva, M. I. Meschaninova, A. L. Mamaev, O. S. Taranov, A. S. Bogachev, S. V. Sidorov, S. D. Nikonov, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, E. V. Dolgova, S. S. Bogachev

Get full text

A review of simulation and modeling approaches in microbiology by A. I. Klimenko, Z. S. Mustafin, A. D. Chekantsev, R. K. Zudin, Yu. G. Matushkin, S. A. Lashin

Get full text

Creation of a recombinant Komagataella phaffii strain, a producer of proteinase K from Tritirachium album by A. B. Beklemishev, M. B. Pykhtina, Ya. M. Kulikov, T. N. Goryachkovskaya, D. V. Bochkov, S. V. Sergeeva, A. R. Vasileva, V. P. Romanov, D. S. Novikova, S. E. Peltek

Get full text

Substantia nigra alterations in mice modeling Parkinson’s disease by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, T. A. Rakhmanova, D. A. Lebedeva, V. S. Kozeneva, N. A. Shavshaeva, N. V. Khotskin, S. Ya. Amstislavsky

Get full text

Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

Get full text

Genomic regions of Solanum tuberosum L. associated with the tuber eye depth by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, A. V. Kochetov, E. K. Khlestkina

“…The aim of this study is to search for loci associated with the eye depth by analyzing Solanum tuberosum varieties from the GenAgro collection of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, genotyped using the Illumina 22K SNP potato array DNA chip. …”
Get full text