Based on network pharmacology and molecular docking to study the mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis by BU Jialiang, SHEN Lin, MENG Yuan, PIAO Yingshi

“…., while the molecular function was mainly involved in the binding of nuclear receptor and cytokine receptors, etc. Among the cellular components, receptor complex and membrane rafts accounted for a large proportion. …”
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Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus by Maryam Mardani, Hossein Mofidi, Ladan Dastgheib, Sara Ranjbar, Nasrin Hamidizadeh

“…Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. …”
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Regulation of miRNAs in obesity and diabetes by Eva Maher, Ava O'Meara, Cathy Brougham

“…This study compares these findings with available literature to identify miRNAs and cytokines that could be novel targets in obesity and diabetes-based therapeutic approaches. …”
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Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection by Jesús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Carlos A. Barrera-Ochoa, Janette Furuzawa-Carballeda

“…H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a central role in limiting host immune response to pathogen. …”
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HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation by Shiguang Yu, Morgan Tripod, Ulus Atasoy, Jing Chen

“…After antigen and/or different cytokine stimulation, CD4+ T cells activated and differentiated into distinct T helper (Th) cells via differential T cell signaling pathways. …”
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T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives by Alessia Alunno, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Giulia Mirabelli, Francesca Cannarile, Paola Cipriani, Roberto Giacomelli, Roberto Gerli

“…In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. …”
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Neuroprotective Effects of Metformin and Berberine in Lipopolysaccharide-Induced Sickness-Like Behaviour in Mice by Triveni Kodi, Sharanya Praveen, Sravan Kumar Paka, Runali Sankhe, Adarsh Gopinathan, Nandakumar Krishnadas, Anoop Kishore

“…Then, proinflammatory cytokines (IL-1β and TNF-α), acetylcholinesterase activity (AChE), and oxidative stress markers were estimated in the brain homogenate. …”
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Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants by Abolfazl Khoshdel, Soleiman Kheiri, Peyman Omidvari, Fahimeh Moradi, Majid Hamidi, Hossein Teimori

“…Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. …”
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Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through Mir-17-5p-regulated Kupffer cell pyroptosis by Yang Tian, Ming Jin, Nanwei Ye, Zhenzhen Gao, Yuancong Jiang, Sheng Yan

“…The survival rates, histology, pro-inflammatory cytokine and chemokine expression, and underlying mechanisms were investigated. …”
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Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes by Annaleise V. Sampey, Paul Hutchinson, Eric F. Morand

“…The lack of effect of annexin I on cytokine-induced PGE2 production suggests PGE2-independent mechanisms for the anti-inflammatory effects of annexin I in vivo.…”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…In the context of disease-induced chronic inflammation, we have explored the role of the pleiotropic cytokine, interleukin (IL)-6 in hippocampal dysfunction using immunofluorescence, electrophysiology and metabolic measurements in dystrophic mdx mice. …”
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Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice by Huihong Zeng, Jiaoqi Cheng, Ying Fan, Yingying Luan, Juan Yang, Feixuan Wang, Shuo Yang, Lijian Shao

“…We reviewed current progress about the effects of fetal liver niche, chemokine, cytokine, and signaling pathways on HSC self-renewal, proliferation, and expansion. …”
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Inflammatory Serum Protein Profiling of Patients with Lumbar Radicular Pain One Year after Disc Herniation by Aurora Moen, Anne-Li Lind, Måns Thulin, Masood Kamali-Moghaddam, Cecilie Røe, Johannes Gjerstad, Torsten Gordh

“…Moreover, a clear overall difference in the serum cytokine profile between the chronic and the recovered patients was demonstrated. …”
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Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy by Veronica Tisato, Paolo Perri, Erika Rimondi, Elisabetta Melloni, Giuseppe Lamberti, Daniela Milani, Paola Secchiero, Giorgio Zauli

“…More importantly, the kinetic of modulation of cytokines/chemokines at the conjunctival level following PRK revealed that while the majority of cytokines/chemokines showed a significant decrease, MCP-1 emerged in light of its pronounced and significant increase soon after PRK and during the follow-up. …”
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Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. …”
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Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation by Qiongqiong Gao, Zhentao Gao, Minzhi Su, Yong Huang, Chi Zhang, Cuiping Li, Hailun Zhan, Bolong Liu, Xiangfu Zhou

“…Furthermore, hUMSCs overexpressing HO-1 inhibited the activation of glial and TLR4/p65/NLRP3 pathway, decreased the levels of pro-inflammatory cytokines in the SDH region. Surprisingly, it markedly increased anti-inflammatory cytokine IL-10, reduced MDA content, and protected GSH concentrations in local environment. …”
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Protease-activated receptor 1 in the pathogenesis of cystic fibrosis by Sarath Ranganathan, Philip Sutton, Sophie Day, Poshmaal Dhar, Kristy Azzopardi, Muhammad A Saeed, Sohinee Sarkar, Jia-Xi Han

“…Weight gain in the ilea of Cftr-/- but not DKO mice was associated with increased ileal levels in the pro-inflammatory cytokine interleukin (IL)-6.Conclusions This study provides the first evidence of PAR1 contributing to the pathological effects of Cftr deficiency in the intestine and suggests a possible effect of PAR1 on the regulation of IL-6 in CF pathogenesis.…”
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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…A clear, multidisciplinary consensus to define and approach thromboinflammation and cytokine release syndrome in SARS-CoV-2 is needed.…”
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O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury by Zhichao Zeng, Xuqiang Liao, Xinjian Zhao

“…The O-GlcNAcylation pathway was modified by manipulating the expression of O-GlcNAc transferase (OGT) or O-GlcNAcase (OGA). Pro-inflammatory cytokine levels and cell pyroptosis were assessed. …”
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Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…Furthermore, Lnc-DC activates STAT3 by phosphorylation (pSTAT3Y705), and the activated STAT3 subsequently induces expression of cytokines which in turn activate STAT3, forming an autocrine loop. …”
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