CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation by Sera Nakisli, Kayleigh Fanelli, Julia LaComb, Lily J. Arnold, Corinne M. Nielsen

“…CNS resident macrophages isolated from cortical and cerebellar regions showed profiles consistent with cytokine-associated immunogenic responses and an immunovigilant pathogen-recognition response, respectively. …”
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Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice by E. Hattinger, S. Scheiblhofer, E. Roesler, T. Thalhamer, J. Thalhamer, R. Weiss

“…Vaccination efficiently suppressed TH2 cytokines, IgE responses, and lung eosinophilia. Protection was maintained after repeated exposure to aerosolized allergen and no TH1 associated pathology was observed. …”
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Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected with Paracoccidioides brasiliensis by Paula Andrea Pino-Tamayo, Juan David Puerta-Arias, Damaris Lopera, Martha Eugenia Urán-Jiménez, Ángel González

“…Survival time was evaluated and mice were sacrificed at 48 h and 96 h after inoculation to assess cellularity, fungal load, cytokine/chemokine levels, and histopathological analysis. …”
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Mesenchymal Stem Cells Combined with Tissue Fusion Technology Promoted Wound Healing in Porcine Bowel Anastomosis by Hong Pan, Ping Keun Lam, See W. Tong, Kevin K. Leung, Anthony Y. Teoh, Enders K. Ng

“…Cell migration and tissue-specific differentiation potency, in addition to potential cytokine and genetic changes, were investigated. Results. …”
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Interleukin-18 and CD30 serum levels in patients with moderate-severe depression by Rosaria Alba Merendino, Antonio Enrico Di Rosa, Giuseppe Di Pasquale, Paola Lucia Minciullo, Carmela Mangraviti, Antonella Costantino, Antonella Ruello, Sebastiano Gangemi

“…Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role in the T-cell-helper type 1 response, is a new member of the family of cytokines produced in the brain. …”
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Behavioral phenotyping of mice deficient for tumor necrosis factor by D. V. Fursenko, N. V. Khotskin, V. A. Kulikov, A. V. Kulikov

“…The tumor necrosis factor (TNF) is a cytokine exerting both homeostatic and pathophysiological roles in the central nervous system (CNS). …”
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Vitamin D and Tinospora cordifolia modulate TLR3 and TLR4 pathways, reduce inflammation, and maintain antimicrobial peptide levels in infected mice by Jamil Ahmad Shobrun, Widyarti Sri, Setiawan Meddy, Rifa’i Muhaimin

“…This study aimed to investigate the effects of vitamin D (VD) and Tinospora cordifolia ethanol extract (TC) on TLR3 and TLR4 receptor protein expression, proinflammatory cytokine (IL1 and IL-6) production, and antimicrobial peptide cathelicidin (CAP) production in CD11b+ cells of mice infected with Escherichia coli. …”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

“…Following infection, a reproducible antiviral cytokine response, including a consistent increase in CXCL10, IL-6, IFN-λ1, IFN-λ2/3, and IFN-β, was detected across all models. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…Cell subpopulations were then treated or not with BL001, a pharmacological agonist of LRH‐1/NR5A2, and processed for: (1) Cell surface marker profiling, (2) cytokine secretome profiling, (3) autologous T‐cell proliferation, (4) RNAseq and (5) proteomic analysis. …”
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Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions by Sibani Sarkar, Subhajit Karmakar, Malini Basu, Pratyasha Ghosh, Mrinal K Ghosh

“…The neurological effect of the virus is mainly due to hypoxia‐driven reactive oxygen species (ROS) and generated cytokine storm. Internalization of SARS‐CoV‐2 triggers ROS production and modulation of the immunological cascade which ultimately initiates the hypercoagulable state and vascular thrombosis. …”
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Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα by Massimo Tortarolo, Daniele Lo Coco, Pietro Veglianese, Antonio Vallarola, Maria Teresa Giordana, Gabriella Marcon, Ettore Beghi, Marco Poloni, Michael J. Strong, Anand M. Iyer, Eleonora Aronica, Caterina Bendotti

“…Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral districts such as the neuromuscular and immune system. …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation has been expanded to include nonhereditary collagen-like diseases, idiopathic inflammatory diseases, and metabolic diseases. …”
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CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…In primates, we observed a long serum half-life, deep and sustained depletion of normal B cells, and remarkable tolerability, in particular, reduced cytokine release when CLN-978 was administered subcutaneously.Conclusions CLN-978 warrants further exploration. …”
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Identification of TTLL8, POTEE, and PKMYT1 as immunogenic cancer-associated antigens and potential immunotherapy targets in ovarian cancer by Esen Yonca Bassoy, Remya Raja, Thomas E. Rubino, Fabian Coscia, Krista Goergen, Paul Magtibay, Kristina Butler, Alessandra Schmitt, Ann L. Oberg, Marion Curtis

“…In patient TILs, increases in cytokine production and tetramer-positive populations identified antigen-specific CD8 T cell responses, which were dependent on antigen presentation by HLA class I. …”
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Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma by Liat Medina, Alex Rabinovich, Benjamin Piura, Victor Dyomin, Ruthy Shaco Levy, Mahmoud Huleihel

“…Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. …”
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Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans by Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang

“…Histopathological and leukocyte analyses revealed a shift towards protective adaptive immune responses in ubp5Δ-infected lungs, characterized by lymphocyte-dominated inflammatory infiltration and an increased Th1/Th17 cytokine response. Under host-associated conditions, ubp5Δ mutants exhibited morphological changes, including distorted shapes and cell wall heterogeneity, alongside defects in key virulence factors such as the polysaccharide capsule and melanin. …”
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Modifying Graft-versus-Host Disease in a Humanized Mouse Model by Targeting Macrophages or B-Cells by Marieke C. H. Hogenes, Suzanne van Dorp, Joyce van Kuik, Filipa R. P. Monteiro, Natalie ter Hoeve, Liane Guedes, Marijke R. van Dijk, Anton C. Martens, Roel A. de Weger

“…Our data show that both macrophage depletion and (early) B-cell depletion in a xenogeneic mouse model can influence the clinical, histological, and cytokine production of a GvHD response.…”
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Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

“…The aim of this study is to investigate the redox status of peritoneal Mp and its cytokine profile during the development of autoimmune diabetes induced by multiple low-dose streptozotocin in BALB/c mice. …”
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Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2... by Asdar Gani, Risfah Yulianty, Supiaty Supiaty, Machirah Rusdy, Gustivanny Dwipa Asri, Dian Eka Satya, Ayu Rahayu Feblina, Harun Achmad

“…The combination of chitosan gel and hydroxyapatite inhibited the production of proinflammatory cytokines and increased the production of BMP-2.…”
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Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases by Nausicaa Clemente, Davide Raineri, Giuseppe Cappellano, Elena Boggio, Francesco Favero, Maria Felicia Soluri, Chiara Dianzani, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules. …”
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