High-fat diet triggers transcriptomic changes in the olfactory bulb by Young-Kook Kim, Danbi Jo, Seoyoon Choi, Juhyun Song

“…Additionally, we assessed plasma cytokine levels in HFD-fed mice. We found differences in the expression of protein-coding and non-coding RNAs involved in insulin, lipid metabolism, neurogenesis, serotonin, dopamine, and gamma-aminobutyric acid–related signaling in the olfactory bulb of HFD-fed mice compared to control mice. …”
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IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway by Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang

“…However, the mechanisms of how cytokines recruit stem cells to target tissue are still unclear. …”
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Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease by Gul Zareen Asifa, Afrose Liaquat, Iram Murtaza, Syed Ali Raza Kazmi, Qamar Javed

“…Controversy exists regarding the link between the cytokine’s variant genotype and CHD among different ethnic groups. …”
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Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction by Olga I. Rudko, Artemii V. Tretiakov, Elena A. Naumova, Eugene A. Klimov

“…Literature data analysis and signal pathway reconstruction and reviewing revealed two possible mechanisms of peroxisome proliferator-activated receptors involvement in pathological anxiety: (1) cytokine expression and neuroinflammation mechanism and (2) regulation of peptidases targeted to anxiety-associated neuropeptides, primarily CCK-4, mechanism.…”
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CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells by Wen-Yao Zhang, Hao Wang, Shaopei Qi, Xixi Wang, Xueru Li, Kun Zhou, Yong Zhang, Ming-Qing Gao

“…Overexpression of CYP1A1 in bovine mammary epithelial cells alleviated the LPS-induced inhibition of epithelial proliferation, abated the LPS-induced increase of gene expression and protein secretion of inflammatory cytokine tumor necrosis factor-α and interleukin-6, and attenuated the LPS-induced activation of NF-κB signaling. …”
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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells by Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard

“…Unlike the defective proliferation of Stat5 DKI CD8+ T cells, Stat5 DKI NK cells have normal proliferation to IL-15 but are susceptible to death upon cytokine withdrawal, with lower Bcl2 and increased active caspases. …”
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Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy by Qingchao Shang, Qingchao Shang, Pei Zhang, Xiao Lei, Lehui Du, Baolin Qu

“…Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, through its receptor (CSF-1R) regulates the differentiation of macrophages. …”
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Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells by Eliane Aparecida Rosseto-Welter, Leticia D’argenio-Garcia, Filipa Blasco Tavares Pereira Lopes, Ana Eduarda Zulim Carvalho, Fernando Flaquer, Vanessa Severo-Lemos, Claudia Concer Viero Nora, Flavio Steinwurz, Lucas Pires Garcia Oliveria, Thiago Aloia, Luiz Vicente Rizzo, Cristóvão Luis Pitangueira Mangueira, Karina Inacio Carvalho

“…To examine the immune status in a Brazilian cohort, we analyzed CD4+ T cells, activation status, cytokine production, and Treg cells in blood of Crohn’s patients. …”
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OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…In NAFLD patients, liver disease may be caused by hypoxia both indirectly by promoting inflammation and insulin resistance and directly by enhancing proinflammatory cytokine production and metabolic dysregulation in liver cells. …”
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Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine by Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zhou

“…In addition, berberine was found to interact with a mixture of biological pathways, such as Alzheimer’s disease-presenilin and -secretase pathways, angiogenesis, apoptosis signalling pathway, FAS signalling pathway, Hungtington disease, inflammation mediated by chemokine and cytokine signalling pathways, interleukin signalling pathway, and p53 pathways. …”
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Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34+CD38− Cells by Kamonnaree Chotinantakul, Patcharee Prasajak, Wilairat Leeanansaksiri

“…In this study, umbilical CB-CD34+ cells were cultured in two different cytokine cocktails: 4 factors (4F = Flt3-L, SCF, IL-6, and TPO) and 5 factors (5F = Wnt1 + 4F) in both serum and serum-free media. …”
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A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins by Linda Christian Carrijo-Carvalho, Durvanei A. Maria, Janaina S. Ventura, Kátia L. P. Morais, Robson L. Melo, Consuelo Junqueira Rodrigues, Ana Marisa Chudzinski-Tavassi

“…Results indicate that modulation effects displayed by lipocalins through this sequence motif involve cell survival, extracellular matrix remodeling, and cytokine signaling. Such effects can be related to the lipocalin roles in disease, development, and tissue repair.…”
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CTLA-4 Engagement Inhibits Th2 but not Th1 Cell Polarisation by Vanessa Ubaldi, Lucia Gatta, Luigia Pace, Gino Doria, Claudio Pioli

“…At variance, once cells are polarised, CTLA-4 engagement inhibits cytokine production in both effector Th2 and Th1 cells. …”
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Association of Interleukin-18 Gene Polymorphism with Susceptibility to Visceral Leishmaniasis in Endemic Area of Bihar, an Indian Population by Dinesh Kumar, Puja Tiwary, Jaya Chakravarty, Shyam Sundar

“…Interleukin-18 (IL-18) is a cytokine that mediates Th1 response by inducing interferon-gamma (IFN-γ) production in T cells and natural killer cells. …”
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Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 by Hilmi Farhan Ramadhani, Annisa Annisa, Aryo Tedjo, Dimas R. Noor, Wisnu Ananta Kusuma

“…All GOs of molecular function, cellular components, and 9 of 14 biological processes were associated with important cytokines related to the COVID-19 cytokine storm present in the resulting cluster. …”
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A minimal mathematical model for the initial molecular interactions of death receptor signalling by Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheurich

“…Tumor necrosis factor (TNF) is the name giving member of a large cytokine family mirrored by a respective cell membrane receptor super family. …”
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Experimental trichuriasis: Changes in the immune response and bacterial translocation during acute phase development illustrated with 3D model animation. by Dayane Alvarinho de Oliveira, Renato Oliveira, Brunna Vianna Braga, Lorian Cobra Straker, Luciana Silva Rodrigues, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Eduardo José Lopes-Torres

“…This study tracks the acute phase of experimental trichuriasis, providing detailed insights into nematode tissue migration stages, inflammatory infiltration, cytokine production, and 2D/3D imaging of the bacterial translocation process. …”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Unique AD glycoproteins were associated with numerous pathways, including Alzheimer’s disease-presenilin pathway (16.6%), inflammation pathway mediated by chemokine and cytokine signaling (9.2%), Wnt signaling pathway (8.2%), and apoptosis signaling pathway (6.7%). …”
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Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases by Qing Ye, Xiao-Jun Xu, Wen-Xia Shao, Yan-Xiang Pan, Xue-Jun Chen

“…Our data demonstrate a significant correlation between MP infection and IgE levels, which is associated with a Th1/Th2 cytokine imbalance.…”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…Functional enrichment analysis highlighted several inflammation-related pathways, such as cytokine-mediated signaling pathway, CXCR chemokine receptor binding, NF-kappa B signaling pathway, TNF signaling pathway, and IL-17 signaling pathway. …”
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