Substance P Increases Cell-Surface Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor): In Vivo Biotinylation of Urothelial Cell-Surface Proteins by Katherine L. Meyer-Siegler, Shen-Ling Xia, Pedro L. Vera

“…Macrophage migration inhibitory factor (MIF), an inflammatory cytokine, and its receptor CD74 are upregulated by bladder inflammation. …”
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Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO by Rupa Biswas, Raymond F. Hamilton, Andrij Holian

“…Silica increased NLRP3 inflammasome activation and release of the proinflammatory cytokine, IL-1β, to a greater extent in MARCO−/− AM compared to wild type (WT) AM. …”
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Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis by Eun Ju Shin, Mi Jeong Sung, Hye Jeong Yang, Myung Sunny Kim, Jin-Taek Hwang

“…In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). …”
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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage by Bolin Cai, Edwin A. Deitch, Luis Ulloa

“…However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. …”
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Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis by Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson

“…Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. …”
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The Role of IL-33 in Gut Mucosal Inflammation by Luca Pastorelli, Carlo De Salvo, Maurizio Vecchi, Theresa T. Pizarro

“…Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses. …”
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Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer by Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou

“…The interaction of immune cells and cytokines in the tumor microenvironment affects the development and prognosis of tumors with an unclear potential regulatory mechanism. …”
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Nanoporosity of Alumina Surfaces Induces Different Patterns of Activation in Adhering Monocytes/Macrophages by Natalia Ferraz, Jaan Hong, Matteo Santin, Marjam Karlsson Ott

“…Human mononuclear cells cultured on alumina membranes with pore diameters of 20 and 200 nm were evaluated in terms of cell adhesion, viability, morphology, and release of proinflammatory cytokines. After 24 hours, cell adhesion was assessed by means of light microscopy and cell viability by measuring LDH release. …”
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The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course by Jessica Mwinyi, Christa Grete-Wenger, Jyrki J. Eloranta, Gerd A. Kullak-Ublick

“…PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. …”
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The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour by Lynne Sykes, David A. MacIntyre, Xiao J. Yap, Tiong Ghee Teoh, Phillip R. Bennett

“…It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. …”
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Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection by Yung-Chun Chuang, Hong-Ru Chen, Trai-Ming Yeh

“…In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Considerable logistical outlays have been deployed to develop and to translate humanised antibodies targeting immune cells, cytokines, and cytokine receptors to the clinic. Very recent phase III trials with the leading agent, a humanised anti-CD3 antibody, call into question whether further development of these biologics represents a step forward or more of the same. …”
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Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients by Yu Zhou, Deli Ye, Xiaofen Yuan, Yonglie Zhou, Jun Xia

“…Interestingly, HbA1c levels and HOMA-β were found to be correlated with a series of BA species. Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs. …”
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Normalization of Deviant Behavior in Muc2+/+ Mice through Dietary Incorporation of Bacillus subtilis Spores by Maryana Morozova, Alexander Alekseev, Arsalan Saeidi, Ekaterina Litvinova

“…The addition of kanamycin-resistant strain Bacillus subtilis BS20 spores to the diet of Muc2+/+ mice for 3 weeks at 107 CFU/g led to a change in behavior and cytokine levels in the gut compared to control C57BL/6 mice. …”
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Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis by Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie

“…Results were compared with the clinical features of s-JIA and serum cytokine levels including interleukin- (IL-) 6, IL-18, and soluble tumor necrosis factor receptors I and II. …”
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Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis by Ming-Yuan Hong, Chin-Chung Tseng, Chia-Chang Chuang, Chia-Ling Chen, Sheng-Hsiang Lin, Chiou-Feng Lin

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. …”
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Regulation of Th1/Th2 cells in asthma development: A mathematical model by Yangjin Kim, Seongwon Lee, You-Sun Kim, Sean Lawler, Yong Song Gho, Yoon-Keun Kim, Hyung Ju Hwang

“…In the present workwe representthe complex network of interactions between cells and molecules by a mathematical model.The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages)and regulatory molecules (IFN-$\gamma$, IL-4, IL-12, TNF-α) in response tohigh, intermediate, and low levels of LPS.The simulations show howvariations in the levels of injected LPSaffect the development ofTh1 or Th2 cell responses through differential cytokine induction.The model also predicts the coexistence ofthese two types of responseunder certain biochemical and biomechanical conditions in the microenvironment.…”
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Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells by Madhavan Nampoothiri, Neetinkumar D. Reddy, Jessy John, Nitesh Kumar, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…Insulin is a cytokine which promotes cell growth. Recently, a few published reports on insulin in different cell lines support the antiapoptotic effect of insulin. …”
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Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report by Jolanta Zuwała-Jagiello, Monika Pazgan-Simon, Krzysztof Simon, Maria Warwas

“…Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. …”
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Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus: Adjuvant Effects during Topical Therapy by Luigi Laino, Silvia Suetti, Isabella Sperduti

“…Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast. …”
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