Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice by Jian-Dong Ren, Jie Ma, Jun Hou, Wen-Jin Xiao, Wei-Hua Jin, Juan Wu, Kai-Hua Fan

“…The results showed that the activation of NLRP3 inflammasome in AP mice was substantially inhibited following the administration of HRS, which was paralleled with the decreased NF-κB activity and cytokines production, attenuated oxidative stress and the amelioration of pancreatic tissue damage. …”
Get full text

Gene Expression Changes in Venous Segment of Overflow Arteriovenous Fistula by Yasuhiro Hashimoto, Akiko Okamoto, Hisao Saitoh, Shingo Hatakeyama, Takahiro Yoneyama, Takuya Koie, Chikara Ohyama

“…In the pathway analysis, the TGF beta signaling pathway, cytokines and inflammatory response pathway, hypertrophy model, and the myometrial relaxation and contraction pathway were significantly upregulated compared with the control cephalic vein. …”
Get full text

Evasion of Early Antiviral Responses by Herpes Simplex Viruses by Paula A. Suazo, Francisco J. Ibañez, Angello R. Retamal-Díaz, Marysol V. Paz-Fiblas, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González

“…While type-I interferons aim at limiting virus spread, cytokines and chemokines will modulate resident and incoming immune cells. …”
Get full text

Protective and immunomodulatory effects of the novel probiotic yeast Pichia kudriavzevii isolated from a home-made kefir during infection in human colon epithelial cells: An explor... by Angela Maione, Marianna Imparato, Annalisa Buonanno, Marilena Galdiero, Elisabetta de Alteriis, Marco Guida, Emilia Galdiero

“…In particular, Y1 and CFS-Y-1 prevented damage to the intestinal epithelial function in LPS-induced Caco-2 cells by upregulating TJ protein expression and reducing ROS accumulation, as well as overproducing anti-inflammatory cytokines. Therefore, the Y1 and its CFS-Y1 possess potential effects on the maintenance of human health and could be considered as a dietary supplementation for food and a promising approach to treat intestinal barrier dysfunction.…”
Get full text

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin by Zhongliang Guo, Qinchuan Li, Yang Han, Yongjie Liang, Zengguang Xu, Tao Ren

“…We revealed that administration of PGRN significantly reduced LPS-induced pulmonary inflammation, as reflected by reductions in total cell and neutrophil counts, proinflammatory cytokines, as well as chemokines in bronchoalveolar lavage (BAL) fluid. …”
Get full text

Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012 by R. Constance Wiener, Usha Sambamoorthi, Richard J. Jurevic

“…Periodontitis is associated with increased cytokines and other markers of inflammation. The purpose of this study is to determine if an independent association between Alanine Aminotransferase and periodontitis exists. …”
Get full text

Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants by Rodrigo Ribeiro, Rayanne Melo, Pedro Tortamano Neto, André Vajgel, Paulo Roberto Eleutério Souza, Renata Cimões

“…Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. …”
Get full text

Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…Mesenchymal stem cells (MSCs) are multipotent cells that have therapeutic potentials mainly through paracrine action via secreting growth factors and cytokines. Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders. …”
Get full text

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB by Xianshe Meng, Shihong Zheng, Zequn Yin, Xuerui Wang, Daigang Yang, Tingfeng Zou, Huaxin Li, Yuanli Chen, Chenzhong Liao, Zhouling Xie, Xiaodong Fan, Jihong Han, Yajun Duan, Xiaoxiao Yang

“…Furthermore, API reduced expression of inflammatory cytokines through inactivation of NF-κB. Taken together, our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.…”
Get full text

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection by Devin Morris, Carlos Guerra, Clare Donohue, Hyoung Oh, Melissa Khurasany, Vishwanath Venketaraman

“…Our results indicate that overproduction of proinflammatory cytokines in HIV+ individuals lead to increased production of free radicals. …”
Get full text

Effects of Zearalenone on IL-2, IL-6, and IFN-γ mRNA Levels in the Splenic Lymphocytes of Chickens by Y. C. Wang, J. L. Deng, S. W. Xu, X. Peng, Z. C. Zuo, H. M. Cui, Y. Wang, Z. H. Ren

“…These data suggest that ZEN has potent effects on the expression of chicken splenic lymphocytes cytokines at the mRNA level.…”
Get full text

Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Adipose-derived stem cells (ADSCs) are known to repair and regenerate damaged tissues by producing bioactive factors, including cytokines, exosomes, and extracellular matrix components, which collectively form the secretome of these cells. …”
Get full text

The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling by Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu

“…In conclusion, GA ameliorated the symptoms of psoriasis, at least in part, through inhibition of inflammatory cytokines and STAT3/mTOR signaling and activation of Tregs in both lymph nodes and spleens. …”
Get full text

Interleukin-1-Beta and Dyslipidemic Syndrome as Major Risk Factors for Thrombotic Complications in Type 2 Diabetes Mellitus by Oana Bădulescu, Codruţa Bădescu, Manuela Ciocoiu, Magda Bădescu

“…The results achieved in our study have revealed the highest thrombotic risk among the groups of diabetic patients, which is in direct correlation with the high values of interleukin-1-beta and the modifications of lipid parameters, acknowledging the data in the literature, according to which hyperglycemia alters endothelial functions directly and indirectly by synthesis of growth factors and cytokines and generates metabolic disorders which would explain the high risk for thrombotic events.…”
Get full text

Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature by Vishnu Garla, Karthik Kovvuru, Shradha Ahuja, Venkatataman Palabindala, Bharat Malhotra, Sohail Abdul Salim

“…It works by removing protein bound hormones and also possibly inflammatory cytokines. Further studies are needed to clarify the role of various modalities of TPE in the treatment of hyperthyroidism.…”
Get full text

In Vitro and In Vivo Dentinogenic Efficacy of Human Dental Pulp-Derived Cells Induced by Demineralized Dentin Matrix and HA-TCP by Kyung-Jung Kang, Min Suk Lee, Chan-Woong Moon, Jae-Hoon Lee, Hee Seok Yang, Young-Joo Jang

“…These cells are differentiated into hard tissue by addition of proper cytokines and biomaterials. Hydroxyapatite-tricalcium phosphates (HA-TCPs) are essential components of hard tissue and generally used as a biocompatible material in tissue engineering of bone. …”
Get full text

Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses by Wujing Dai, Fangwei Liu, Chao Li, Yiping Lu, Xiaowei Lu, Sitong Du, Ying Chen, Dong Weng, Jie Chen

“…Reciprocally, enhanced Th17 response was responsible for the further accumulation of neutrophils and production of proinflammatory cytokines. In addition, blockade of Wnt/β-catenin pathway delayed the Th1/Th2 polarization by inhibiting Tregs and Th2 response. …”
Get full text

JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells by Ling Yan, Shengnan Liu, Chen Wang, Fei Wang, Yingli Song, Nan Yan, Shuhua Xi, Ziyou Liu, Guifan Sun

“…In this study we examined ROS production and TNF-α, IL-1β inflammatory cytokines releasing, and the expression of MAPKs in BV-2 microglia cells treated with fluoride. …”
Get full text

Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice by Talero Elena, Di Paola Rosanna, Mazzon Emanuela, Emanuela Esposito, Motilva Virginia, Cuzzocrea Salvatore

“…AM treatment attenuated the recruitment of leucocytes in the lung tissue and the generation and/or the expression of the proinflammatory cytokines as well as the expression of the intercellular cell adhesion molecules. …”
Get full text

Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease by Sandeep Vasant More, Hemant Kumar, In Su Kim, Soo-Yeol Song, Dong-Kug Choi

“…Although microglia forms the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly affect neurons by releasing various molecular mediators such as inflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β), nitric oxide, prostaglandin E2, and reactive oxygen and nitrogen species. …”
Get full text